Partner: A.R. Boccaccini

Friedrich-Alexander University of Erlangen-Nürnberg (DE)

Recent publications
1.Bretcanu O., Misra S.K., Yunos D.M., Boccaccini A.R., Roy I., Kowalczyk T., Błoński S., Kowalewski T.A., Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering, MATERIALS CHEMISTRY AND PHYSICS, ISSN: 0254-0584, DOI: 10.1016/j.matchemphys.2009.08.011, Vol.118, pp.420-426, 2009

Biodegradable polymeric nanofibrous coatings were obtained by electrospinning different polymers onto sintered 45S5 Bioglass®-based glass-ceramic pellets. The investigated polymers were poly(3-hydroxybutyrate) (P3HB), poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV) and a composite of poly(caprolactone) (PCL) and poly(ethylene oxide) (PEO) (PCL–PEO). The fibrous coatings morphology was evaluated by optical microscopy and scanning electron microscopy. The electrospinning process parameters were optimised to obtain reproducible coatings formed by a thin web of polymer nanofibres. In-vitro studies in simulated body fluid (SBF) were performed to investigate the bioactivity and mineralisation of the substrates by inducing the formation of hydroxyapatite (HA) on the nanofiber-coated pellets. HA crystals were detected on all samples after 7 days of immersion in SBF, however the morphology of the HA layer depended on the characteristic fibre diameter, which in turn was a function of the specific polymer-solvent system used. The bioactive and resorbable nanofibrous coatings can be used to tailor the surface topography of bioactive glass-ceramics for applications in tissue engineering scaffolds.


Electrospinning, Nanofibers, Bioglass®, Polyhydroxyalkanoates, Tissue engineering

Bretcanu O.-other affiliation
Misra S.K.-other affiliation
Yunos D.M.-other affiliation
Boccaccini A.R.-Friedrich-Alexander University of Erlangen-Nürnberg (DE)
Roy I.-other affiliation
Kowalczyk T.-IPPT PAN
Błoński S.-IPPT PAN
Kowalewski T.A.-IPPT PAN

Conference abstracts
1.Golasiński K.M., Pieczyska E.A., Detsch R., Boccaccini A.R., Takesue N., Evaluation of mechanical properties and biocompatibility of Gum Metal for implant applications, 7th KMM-VIN Industrial Workshop: Biomaterials: Key Technologies for Better Healthcare, 2017-09-27/09-28, Erlangen (DE), pp.46-46, 2017

In this work, mechanical properties of a β-Ti alloy Gum Metal (Ti–23Nb–0.7Ta–2.0Zr–1.2O at.%, free of cytotoxic content), which was fabricated at Toyota Central Research&Development Laboratories, Inc., were investigated. It was confirmed that Gum Metal is characterized by a low Young's modulus (around 60 GPa), high strength (over 1000 MPa) and a large range of reversible deformation, which are important features in the context of potential implant applications. Moreover, a comprehensive assessment of biocompatibility was realized. Properties of Gum Metal were contrasted with those of Ti-6Al-4V (ELI) which was taken as reference. Surface conditions, such as topography, roughness and structural composition, were analyzed. Evaluation of biocompatibility for the alloys was performed by cell attachment and spreading analysis after predefined cell culture periods. Gum Metal presented excellent properties, what makes it a goodcandidate for implant applications.


Gum Metal, titanium alloy, biocompatibility, implant applications

Golasiński K.M.-IPPT PAN
Pieczyska E.A.-IPPT PAN
Detsch R.-Friedrich-Alexander University of Erlangen-Nürnberg (DE)
Boccaccini A.R.-Friedrich-Alexander University of Erlangen-Nürnberg (DE)
Takesue N.-Fukuoka University (JP)