Partner: Katarzyna Roszkowska-Purska


Recent publications
1.Dobruch-Sobczak K., Piotrzkowska-Wróblewska H., Roszkowska-Purska K., Nowicki A., Jakubowski W., Usefulness of combined BI-RADS analysis and Nakagami statistics of ultrasound echoes in the diagnosis of breast lesions, Clinical Radiology, ISSN: 0009-9260, DOI: 10.1016/j.crad.2016.11.009, Vol.72, pp.339.e7-339.e15, 2017
Abstract:

AIM: To develop a method combining the statistics of the ultrasound backscatter and the Breast Imaging-Reporting and Data System (BI-RADS) classification to enhance the differentiation of breast tumours.
MATERIALS AND METHODS: The Nakagami shape parameter m was used to characterise the scatter properties of breast tumours. Raw data from the radiofrequency (RF) echo-signal and Bmode images from 107 (32 malignant and 75 benign) lesions and their surrounding tissue were recorded. Three different characteristic values of the shape parameters of m (maximum [mLmax], minimum [mLmin] and average [mLavg]) and differences between m parameters (Dmmax, Dmmin, Dmavg) of the lesions and their surrounding tissues were assessed. A lesion with a BI-RADS score of 3 was considered benign, while a lesion with a score of 4 was considered malignant (a cut-off of BI-RADS 3/4 was set for all patients).
RESULTS: The area under the receiver operating characteristic (ROC) curve (AUC) was equal to 0.966 for BI-RADS, with 100% sensitivity and 54.67% specificity. All malignant lesions were diagnosed correctly, whereas 34 benign lesions were biopsied unnecessarily. In assessing the Nakagami statistics, the sum of the sensitivity and specificity was the best for mLavg (62.5% and 93.33%, respectively). Only four of 20 lesions were found over the cut-off value in BI-RADS of 4a. When comparing the differences in m parameters, Dmavg had the highest sensitivity of 90% (only three of 32 lesions were false negative). These three lesions were classified as BIRADS category 4c. The combined use of B-mode and mLmin parameter improve the AUC up to 0.978 (pĽ0.088), compared to BI-RADS alone.
CONCLUSION: The combination of the parametric imaging and the BI-RADS assessment does not significantly improve the differentiation of breast lesions, but it has the potential to better identify the group of patients with mainly benign lesions that have a low level of suspicion for malignancy with a BI-RADS score of 4a.

Affiliations:
Dobruch-Sobczak K.-IPPT PAN
Piotrzkowska-Wróblewska H.-IPPT PAN
Roszkowska-Purska K.-other affiliation
Nowicki A.-IPPT PAN
Jakubowski W.-other affiliation
2.Piotrzkowska-Wroblewska H., Dobruch-Sobczak K., Litniewski J., Chrapowicki E., Roszkowska-Purska K., Nowicki A., Differentiation of the breast lesions using statistics of backscattered echoes, HYDROACOUSTICS, ISSN: 1642-1817, Vol.19, pp.319-328, 2016
Abstract:

The purpose of this study was to evaluate the accuracy of statistical properties of the backscttered ultrasound in differential diagnosis of the breast lesions. The B-mode images together with the appropriate RF echoes from the breast lesions and surrounding tissues were collected. The RF data were processed for the statistics of the backscattered echo signals using K and Nakagami distributions characterized by the M and m parameters, respectively. Based on both, M and m parameters, a set of 18 parameters was derived.

From the point of view of the sensitivity of detection of the cancer the best score was obtained using maximum value of M parameter, the best specificity was received using the differential Nakagami parameter (the differential values between lesions and surrounding tissues). In conclusion the quantitative sonography is a method which has potential to be a complementary tool for classification of the breast lesions.

Keywords:

quantitative ultrasound, breast cancer, Nakagami distribution, K dstribution

Affiliations:
Piotrzkowska-Wroblewska H.-IPPT PAN
Dobruch-Sobczak K.-IPPT PAN
Litniewski J.-IPPT PAN
Chrapowicki E.-Center of Oncology Memorial Institute (PL)
Roszkowska-Purska K.-other affiliation
Nowicki A.-IPPT PAN