Partner: M. Szubielski

Mazovia Regional Hospital in Siedlce (PL)

Recent publications
1.Nowicki A., Secomski W., Trawiński Z., Lewandowski M., Trots I., Szubielski M., Olszewski R., Estimation of radial artery reactive response using high frequency ultrasound, HYDROACOUSTICS, ISSN: 1642-1817, Vol.19, pp.297-306, 2016
Abstract:

Background:
There is a growing interest in the application of non-invasive clinical tools allowing one to assess the endothelial function, preceding atherosclerosis. The precision in estimating of the artery Flow Mediated Vasodilation (FMD) using standard 10-12 MHz linear array probes does not exceed 0.2 mm, far beyond that required.

Methods:
We have introduced a wide-band, high frequency 25-30 MHz, Golay encoded wobbling type imaging to measure dilation of the radial artery instead of the brachial one. 18 young volunteers, and 4 volunteers with cardiac events history, were examined. In the second approach 20 MHz linear scanning combined with 20 MHz pulsed Doppler attached to the linear array was used. The radial artery FMD was normalized using shear rate at the radial artery wall.

Results and Conclusions:
For the “healthy” group, the FMD resulting from reactive hyperemia response was over 20%; while in the “atherosclerotic” group, the FMD was at least twice as small, not exceeding 10%. The shear rate (SR) normalized FMDSR was in the range from 7.8 to 9.9 in arbitrary units, while in patients with minor cardiac history FMDSR was clearly lower, 6.8 to 7.6. The normalized FMDSR of radial artery RARR can be an alternative to the brachial FMD where the precision of measurements is lower and the diameter dilation does not exceed 7-10%.

Keywords:

thick film transducers, atherosclerosis, flow mediated vasodilation

Affiliations:
Nowicki A.-IPPT PAN
Secomski W.-IPPT PAN
Trawiński Z.-IPPT PAN
Lewandowski M.-IPPT PAN
Trots I.-IPPT PAN
Szubielski M.-Mazovia Regional Hospital in Siedlce (PL)
Olszewski R.-IPPT PAN

Conference papers
1.Nowicki A., Trawiński Z., Gambin B., Secomski W., Szubielski M., Parol M., Olszewski R., Measurements of Flow Mediated Dilation and Shear Rate in the Radial Artery Using 20 MHz Ultrasonic System in Patients with Coronary Artery Disease., XXI Międzynarodowy Kongres Polskiego Towarzystwa Kardiologicznego. , 2017-09-21/09-23, Katowice. (PL), pp.1-1, 2017
Abstract:

A novel high-frequency scanning system, with a 20-MHz linear array transducer combined with 20-MHz pulsed Doppler, was introduced to evaluate the degree of radial artery flow-mediated dilation (FMD) and shear rate (SR)-normalized FMD (FMD/SR) after 5 min of reactive hyperaemia. In group I, comprising 27 healthy volunteers, FMD was 15 ± 4.8%, and in group II, comprising 17 patients with coronary artery disease, FMD was significantly smaller, being equal to 4.6 ± 4%. FMD/SR was equal to 5.365 ± 4.835·10-4 in group I and 1.3 ± 0.89·10-4 in group II. Statistically significant differences between the two groups were confirmed by Wilcoxon-Mann-Whitney test for FMD and FMD/SR (p-values < 0.01). AUCs of ROC curves for FMD and FMD/SR were greater than 0.9. The results confirm the usefulness of the proposed measurements of radial artery FMD and SR in differentiation of normal subjects from those with atherosclerotic lesions.

Keywords:

flow mediated vasodilation, radial artery, shear rate, reactive hyporaemia, endothelium, pulsed Doppler, ultrasonography.

Affiliations:
Nowicki A.-IPPT PAN
Trawiński Z.-IPPT PAN
Gambin B.-IPPT PAN
Secomski W.-IPPT PAN
Szubielski M.-Mazovia Regional Hospital in Siedlce (PL)
Parol M.-The John Paul’s II Western Hospital in Grodzisk Mazowiecki (PL)
Olszewski R.-IPPT PAN