Partner: P. Karłowicz

Sonomed Sp. z o.o, Warszawa (PL)

Recent publications
1.Lewandowski M., Walczak M., Karwat P., Witek B., Karłowicz P., Research and Medical Transcranial Doppler System, ARCHIVES OF ACOUSTICS, ISSN: 0137-5075, DOI: 10.1515/aoa-2016-0074, Vol.41, No.4, pp.773-781, 2016
Abstract:

A new ultrasound digital transcranial Doppler system (digiTDS) is introduced. The digiTDS enables diagnosis of intracranial vessels which are rather difficult to penetrate for standard systems. The device can display a color map of flow velocities (in time-depth domain) and a spectrogram of a Doppler signal obtained at particular depth. The system offers a multigate processing which allows to display a number of spectrograms simultaneously and to reconstruct a flow velocity profile.
The digital signal processing in digiTDS is partitioned between hardware and software parts. The hardware part (based on FPGA) executes a signal demodulation and reduces data stream. The software part (PC) performs the Doppler processing and display tasks. The hardware-software partitioning allowed to build a flexible Doppler platform at a relatively low cost.
The digiTDS design fulfills all necessary medical standards being a new useful tool in the transcranial field as well as in heart velocimetry research.

Keywords:

Doppler system, digital signal processing, hardware-software partitioning, field programmable gate arrays

Affiliations:
Lewandowski M.-IPPT PAN
Walczak M.-IPPT PAN
Karwat P.-IPPT PAN
Witek B.-IPPT PAN
Karłowicz P.-Sonomed Sp. z o.o, Warszawa (PL)
2.Gawlikowski M., Lewandowski M., Nowicki A., Kustosz R., Walczak M., Karwat P., Karłowicz P., The Application of Ultrasonic Methods to Flow Measurement and Detection of Microembolus in Heart Prostheses, ACTA PHYSICA POLONICA A, ISSN: 0587-4246, DOI: 10.12693/APhysPolA.124.417, Vol.124, No.3, pp.417-420, 2013
Abstract:

For the last 20 years the world cardiosurgery has presented a considerable change of attitude to mechanical circulatory support. In spite of technological progress the main problems in ventricular assist devices are: thrombosis and low accuracy of flow measurements. In this paper the prototype of multi-gate Doppler flowmeter intended for cardiac assist system ReligaHeart EXT has been presented as well as the possibility of ultrasonic micro embolus detection.

Keywords:

artificial heart, microemboli, ultrasound Doppler

Affiliations:
Gawlikowski M.-other affiliation
Lewandowski M.-IPPT PAN
Nowicki A.-IPPT PAN
Kustosz R.-other affiliation
Walczak M.-IPPT PAN
Karwat P.-IPPT PAN
Karłowicz P.-Sonomed Sp. z o.o, Warszawa (PL)

List of chapters in recent monographs
1.
328
Lewandowski M., Walczak M., Karwat P., Nowicki A., Karłowicz P., Polskie protezy serca, opracowanie konstrukcji, badania kwalifikacyjne, przedkliniczne i kliniczne., rozdział: Wykonanie modelu i implementacja oprogramowania do ultradźwiękowego pomiaru przepływu krwi, FRK, Zabrze. Praca zbiorowa pod redakcją: Kustosz R., Gonsior M., Jarosz A., pp.3-21, 2013

Conference abstracts
1.Olszewski R., Dobkowska-Chudon W., Wrobel M., Karlowicz P., Dabrowski A., Krupienicz A., Targowski T., Nowicki A., Is Acoustocerebrography a new noninvasive method for early detection of the brain changes in patients with hypertension ?, ESC Congress 2017, European Society of Cardiology Congress 2017, 26-30 August, Barcelona, Spain, 2017-08-26/08-30, Barcelona (ES), DOI: 10.1093/eurheartj/ehx501.P190, No.38 1, pp.36, 2017
Abstract:

Background: Hypertension (HT) is the leading cause of global disease burden and overall health loss. The brain is one of the main target organs affected by HT. HT is a potentially modifiable risk factor that leads to the formation of large vessel macroangiopathy, small vessel disease, microangiopathy, and microhemorrhages. Early detection of the brain changes (BC) gives a chance to receive appropriate treatment and protection from irreversible damage. Acoustocerebrography (ACG) is a set of techniques to capture the states of human brain tissue, and its changes on its molecular and cellular level. It is based on noninvasive measurements of various parameters obtained by analyzing an ultrasound pulse emitted across the human's skull. The main idea of this method relies in the relation between the tissue density, bulk modulus, and speed of propagation, for ultrasound waves in this medium. In our previous studies we showed that ACG is an effective method for detecting white matter lesions compared to the Magnetic Resonance Imaging. Additionally we showed that ACG allows to obtain a differentiated signal originates from atrial fibrillation (AF) patients and high-risk patients wit AF and HT.

Aim: The aim of the study was early detection of the BC in patients with HT using ACG.

Methods: The study included 136 female and 98 male patients (age 43.6±15.7 years) who were surveyed in the clinical research. The patients were divided into two groups: group I (patients with HT) n=33, and control group II (patients without HT) n=201. Phase and amplitude of all frequency components of the received signals from the brain path were extracted and compared to the phase and amplitude of the transmitted pulse. By doing so, the time of flight and the attenuation of each frequency component were calculated. Additionally, a fast Fourier transformation (FFT) was performed and its features were extracted.

Results: After introducing a machine learning technique, the ROC plot with an AUC of 0.929 with sensitivity 0.879 and specificity 0.831 was obtained (Fig. 1).
Conclusion: ACG is new promising method, which allows for early detection of change in the brain in the patients with HT.

Affiliations:
Olszewski R.-IPPT PAN
Dobkowska-Chudon W.-District Hospital, Cardiology, Radom (PL)
Wrobel M.-Sonovum A.G., Leipzig, (DE)
Karlowicz P.-Sonomed Sp. z o.o, Warszawa (PL)
Dabrowski A.-MTZ Clinical Research, Warszawa (PL)
Krupienicz A.-Medical University of Warsaw (PL)
Targowski T.-National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw (PL)
Nowicki A.-IPPT PAN
2.Lewandowski M., Walczak M., Karwat P., Witek B., Nowicki A., Karłowicz P., Research & Medical Doppler platform, 11th Congrès Français d'Acoustique, 2012 IOA annual meeting, 2012-04-23/04-27, Nantes (FR), pp.x1-x6, 2012
Abstract:

A new ultrasound digital transcranial Doppler system (digiTDS) is introduced. The digiTDS enables diagnosis of intracranial vessels which are difficult to penetrate for standard systems. The device can display a color map of flow velocities in time-depth domain and a spectrogram of a Doppler signal received from a particular depth. The system offers a multigate processing that allows to display simultaneously a number of spectrograms and to reconstruct a flow velocity profile. The digital signal processing in digiTDS is partitioned between hardware and software parts. The hardware part (based on FPGA) executes a signal demodulation and reduces data stream. The software part (PC) performs the Doppler processing and display tasks. The hardware-software partitioning allowed to build a flexible Doppler platform at a relatively low cost. The digiTDS design fulfills all necessary medical standards being a new useful tool in transcranial field as well as in heart velocimetry research.

Keywords:

ultrasound transcranial Doppler, RF signal processing, DSP, FPGA

Affiliations:
Lewandowski M.-IPPT PAN
Walczak M.-IPPT PAN
Karwat P.-IPPT PAN
Witek B.-IPPT PAN
Nowicki A.-IPPT PAN
Karłowicz P.-Sonomed Sp. z o.o, Warszawa (PL)

Patents
Numer/data zgłoszenia patentowego
Ogłoszenie o zgłoszeniu patentowym
Twórca / twórcy
Tytuł
Kraj i Nazwa uprawnionego z patentu
Numer patentu
Ogłoszenie o udzieleniu patentu
pdf
277279
1989-01-20
BUP 15/90
1990-07-23
Marciniak A., Nowicki A., Secomski W., Karłowicz P., Piechocki M., Liwski J.
Ultradźwiękowa głowica sektorowa
PL, Instytut Podstawowych Problemów Techniki PAN
157977
WUP 07/92
1992-07-31
255681
1985-10-08
-
1990-07-31
Karłowicz P., Liwski J., Nowicki A.
Sposób określania kierunku przepływu w cyfrowym pomiarze prędkości przepływu z zastosowaniem impulsowego przepływomierza dopplerowskiego
PL, Instytut Podstawowych Problemów Techniki PAN
149954
-
1987-05-18
247801
1984-05-23
-
1989-04-29
Karłowicz P., Nowicki A., Piechocki M., Secomski W.
Ultradźwiękowy przepływomierz dopplerowski do rejestracji maksymalnej prędkości cieczy
PL, Instytut Podstawowych Problemów Techniki PAN
144601
-
1985-12-03
239097
1982-11-18
-
1986-11-15
Filipczyński L., Karłowicz P., Nowicki A.
Sposób i urządzenie do rozpoznania zaburzenia przepływu cieczy, zwłaszcza krwi
PL, Instytut Podstawowych Problemów Techniki PAN
136932
-
1984-12-03