Partner: R.Z. Słapa


Recent publications
1.Dobruch-Sobczak K., Bakuła-Zalewska E., Gumińska A., Słapa R. Z., Mlosek K., Wareluk P., Jakubowski W., Dedecjus M., Diagnostic performance of shear wave elastography parameters alone and in combination with conventional b-mode ultrasound parameters for the characterization of thyroid nodules: a prospective, dual-center study, ULTRASOUND IN MEDICINE AND BIOLOGY, ISSN: 0301-5629, DOI: 10.1016/j.ultrasmedbio.2016.07.010, Vol.42, No.12, pp.2803-2811, 2016
Abstract:

The aims of our study were to determine whether shear wave elastography (SWE) can improve the conventional B-mode differentiation of thyroid lesions, determine the most accurate SWE parameter for differentiation and assess the influence of microcalcifications and chronic autoimmune thyroiditis on SWE values. We examined 119 patients with 169 thyroid nodules who prospectively underwent B-mode ultrasound and SWE using the same ultrasound machine. The parameters assessed using SWE were: mean elasticity within the entire lesion (SWE-whole) and mean (SWE-mean) and maximum (SWE-max) elasticity for a 2-mm-diameter region of interest in the stiffest portion of the lesion, excluding microcalcifications. The discriminant powers of a generalized estimating equation model including B-mode parameters only and a generalized estimation equation model including both B-mode and SWE parameters were assessed and compared using the area under the receiver operating characteristic curve, in association with pathologic verification. In total, 50 and 119 malignant and benign lesions were detected. In generalized estimated equation regression, the B-mode parameters associated with higher odds ratios (ORs) for malignant lesions were microcalcifications (OR = 4.3), hypo-echogenicity (OR = 3.13) and irregular margins (OR = 10.82). SWE-max was the only SWE independent parameter in differentiating between malignant and benign tumors (OR = 2.95). The area under the curve for the B-mode model was 0.85, whereas that for the model combining B-mode and SWE parameters was 0.87. There was no significant difference in mean SWE values between patients with and without chronic autoimmune thyroiditis. The results of the present study suggest that SWE is a valuable tool for the characterization of thyroid nodules, with SWE-max being a significant parameter in differentiating benign and malignant lesions, independent of conventional B-mode parameters. The combination of SWE parameters and conventional B-mode parameters does not significantly improve the diagnosis of malignant thyroid nodules. The presence of microcalcifications can influence the SWE-whole value, whereas the presence of chronic autoimmune thyroiditis may not.

Keywords:

Shear wave elastography, B-Mode ultrasound, Thyroid nodules, Diagnostic performance, Malignant, Benign

Affiliations:
Dobruch-Sobczak K.-other affiliation
Bakuła-Zalewska E.-Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (PL)
Gumińska A.-other affiliation
Słapa R. Z.-other affiliation
Mlosek K.-Medical University of Warsaw (PL)
Wareluk P.-Medical University of Warsaw (PL)
Jakubowski W.-other affiliation
Dedecjus M.-Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (PL)
2.Słapa R.Z., Kasperlik-Załuska A.A., Migda B., Otto M., Dobruch-Sobczak K., Jakubowski W.S., Echogenicity of benign adrenal focal lesions on imaging with new ultrasound techniques – report with pictorial presentation, Journal of Ultrasonography, ISSN: 2084-8404, DOI: 10.15557/JoU.2015.0034, Vol.15, pp.368-376, 2015
Abstract:

Aim: The aim of the research was to assess the echogenicity of benign adrenal focal lesions using new ultrasound techniques. Material and method: 34 benign adrenal masses in 29 patients were analyzed retrospectively. The examinations were conducted using Aplio XG (Toshiba, Japan) ultrasound scanner with a convex probe 1–6 MHz in the B-mode presentation with the combined use of new ultrasound techniques: harmonic imaging and spatial compound sonography. The size of the adrenal tumors, their echogenicity and homogeneity were analyzed. Statistical analysis was conducted using the STATISTICA 10 software. Results: The following adrenal masses were assessed: 12 adenomas, 10 nodular hyperplasias of adrenal cortex, 7 myelolipomas, 3 pheochromocytomas, a hemangioma with hemorrhage and a cyst. The mean diameter of nodular hyperplasia of adrenal cortex was not statistically different from that of adenomas (p = 0.075). The possibility of differentiating between nodular hyperplasia and adenoma using the parameter of hypoechogenicity or homogeneity of the lesion was demonstrated with the sensitivity and specificity of 100% and 41.7%, respectively. The larger the benign adrenal tumor was, the more frequently did it turn out to have a mixed and inhomogenous echogenicity (p < 0.05; ROC areas under the curve: 0.832 and 0.805, respectively). Conclusions: A variety of echogenicity patterns of benign adrenal focal lesions was demonstrated. The image of an adrenal tumor correlates with its size. The ultrasound examination, apart from its indisputable usefulness in detecting and monitoring adrenal tumors, may also allow for the differentiation between benign lesions. However, for lesions found incidentally an algorithm for the assessment of adrenal incidentalomas is applicable, which includes computed tomography and magnetic resonance imaging.

Keywords:

adrenal glands, adrenal masses, ultrasound, echogenicity

Affiliations:
Słapa R.Z.-other affiliation
Kasperlik-Załuska A.A.-other affiliation
Migda B.-other affiliation
Otto M.-other affiliation
Dobruch-Sobczak K.-IPPT PAN
Jakubowski W.S.-other affiliation
3.Słapa R.Z., Jakubowski W.S., Dobruch-Sobczak K., Kasperlik-Załuska A.A., Standards of ultrasound imaging of the adrenal glands, Journal of Ultrasonography, ISSN: 2084-8404, DOI: 10.15557/JoU.2015.0035, Vol.15, pp.377-387, 2015
Abstract:

Adrenal glands are paired endocrine glands located over the upper renal poles. Adrenal pathologies have various clinical presentations. They can coexist with the hyperfunction of individual cortical zones or the medulla, insufficiency of the adrenal cortex or retained normal hormonal function. The most common adrenal masses are tumors incidentally detected in imaging examinations (ultrasound, tomography, magnetic resonance imaging), referred to as incidentalomas. They include a range of histopathological entities but cortical adenomas without hormonal hyperfunction are the most common. Each abdominal ultrasound scan of a child or adult should include the assessment of the suprarenal areas. If a previously non-reported, incidental solid focal lesion exceeding 1 cm (incidentaloma) is detected in the suprarenal area, computed tomography or magnetic resonance imaging should be conducted to confirm its presence and for differentiation and the tumor functional status should be determined. Ultrasound imaging is also used to monitor adrenal incidentaloma that is not eligible for a surgery. The paper presents recommendations concerning the performance and assessment of ultrasound examinations of the adrenal glands and their pathological lesions. The article includes new ultrasound techniques, such as tissue harmonic imaging, spatial compound imaging, three-dimensional ultrasound, elastography, contrast-enhanced ultrasound and parametric imaging. The guidelines presented above are consistent with the recommendations of the Polish Ultrasound Society.

Keywords:

adrenal glands, adrenal masses, ultrasound, standards

Affiliations:
Słapa R.Z.-other affiliation
Jakubowski W.S.-other affiliation
Dobruch-Sobczak K.-IPPT PAN
Kasperlik-Załuska A.A.-other affiliation
4.Dobruch-Sobczak K., Gumińska A., Bakuła-Zalewska E., Mlosek K., Słapa R.Z., Wareluk P., Krauze A., Ziemiecka A., Migda B., Jakubowski W., Dedecjus M., Shear wave elastography in medullary thyroid carcinoma diagnostics, Journal of Ultrasonography, ISSN: 2084-8404, DOI: 10.15557/JoU.2015.0033, Vol.15, pp.358-367, 2015
Abstract:

Shear wave elastography (SWE) is a modern method for the assessment of tissue stiffness. There has been a growing interest in the use of this technique for characterizing thyroid focal lesions, including preoperative diagnostics. Aim: The aim of the study was to assess the clinical usefulness of SWE in medullary thyroid carcinoma (MTC) diagnostics. Materials and methods: A total of 169 focal lesions were identified in the study group (139 patients), including 6 MTCs in 4 patients (mean age: 45 years). B-mode ultrasound and SWE were performed using Aixplorer (SuperSonic, Aix-en-Provence), with a 4–15 MHz linear probe. The ultrasound was performed to assess the echogenicity and echostructure of the lesions, their margin, the halo sign, the height/width ratio (H/W ratio), the presence of calcifications and the vascularization pattern. This was followed by an analysis of maximum and mean Young’s (E) modulus values for MTC (EmaxLR, EmeanLR) and the surrounding thyroid tissues (EmaxSR, EmeanSR), as well as mean E-values (EmeanLRz) for 2 mm region of interest in the stiffest zone of the lesion. The lesions were subject to pathological and/or cytological evaluation. Results: The B-mode assessment showed that all MTCs were hypoechogenic, with no halo sign, and they contained micro- and/ or macrocalcifications. Ill-defined lesion margin were found in 4 out of 6 cancers; 4 out of 6 cancers had a H/W ratio > 1. Heterogeneous echostructure and type III vascularity were found in 5 out of 6 lesions. In the SWE, the mean value of EmaxLR for all of the MTCs was 89.5 kPa and (the mean value of EmaxSR for all surrounding tissues was) 39.7 kPa Mean values of EmeanLR and EmeanSR were 34.7 kPa and 24.4 kPa, respectively. The mean value of EmeanLRz was 49.2 kPa. Conclusions: SWE showed MTCs as stiffer lesions compared to the surrounding tissues. The lesions were qualified for fine needle aspiration biopsy based on B-mode assessment. However, the diagnostic algorithm for MTC is based on the measurement of serum calcitonin levels, B-mode ultrasound and FNAB.

Keywords:

medullary thyroid carcinoma, thyroid, ultrasound, shear wave elastography

Affiliations:
Dobruch-Sobczak K.-IPPT PAN
Gumińska A.-other affiliation
Dedecjus M.-Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (PL)
Bakuła-Zalewska E.-Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (PL)
Mlosek K.-Medical University of Warsaw (PL)
Słapa R.Z.-other affiliation
Wareluk P.-Medical University of Warsaw (PL)
Krauze A.-other affiliation
Ziemiecka A.-other affiliation
Migda B.-other affiliation
Jakubowski W.-other affiliation

Conference abstracts
1.Dobruch-Sobczak K., Gumińska A., Bakuła-Zalewska E., Piotrzkowska H., Mlosek K., Słapa R.Z., Wareluk P., Migda B., Olszewski W., Jakubowski W., Nowicki A., Dedecjus M., Wartość sonoelastografii fali poprzecznej (SWE) w szacowaniu ryzyka złośliwości zmian ogniskowych tarczycy, V Konferencja Rak Tarczycy i inne nowotwory zlośliwe układu wydzielania wewnętrznego, 2015-11-14/11-17, Wisła (PL), Vol.66, pp.1, 2015