Robert Olszewski, Ph.D., Dr. Habil.

Department of Ultrasound (ZU)
Division of Ultrasonic Introscopy (PIU)
position: specialist
e-mail: rolsze

Recent publications
1.Kowalewski P.K., Olszewski R., Walędziak M.S., Janik M.R., Kwiatkowski A., Paśnik K., Cigarette smoking and its impact on weight loss after bariatric surgery: A single center, retrospective study, Surgery for Obesity and Related Diseases, ISSN: 1550-7289, DOI: 10.1016/j.soard.2018.05.004, Vol.14, No.8, pp.1163-1166, 2018
Abstract:

Background: Smoking cessation is often associated with weight gain. This study was conducted to verify whether it affects outcomes of bariatric surgery. Objectives: To present cigarette consumption among patients after bariatric surgery in a long-term follow-up and to evaluate whether smoking cessation impacts weight loss. Setting: High-volume bariatric center, Military Hospital, Poland. Methods: We collected data of patients who underwent bariatric surgery between 2003 and 2009. The data included sex, age, weight, body mass index, and smoking habits. An online survey regarding current weight, co-morbidities, and smoking was distributed. Percentage excess weight loss was calculated with an ideal weight for body mass index of 25 kg/m2. Results: One hundred seven patients had laparoscopic adjustable gastric banding between 2003 and 2006; 47 were included in the study. The mean follow-up time was 11.2 (±1.2). Of patients, 51% (n = 24) were smokers before surgery. In the follow-up 43% (n = 20) were smokers, of whom 4 patients began smoking after surgery. Twenty-seven patients were nonsmokers, 8 of whom quit over the years (33% of previous smokers). One hundred twenty-seven underwent laparoscopic sleeve gastrectomy between 2006 and 2009; 84 were included in the study. Our median follow-up was 8.0 years. Thirty-two patients never smoked; 52 were smoking before surgery, yet 24 successfully quit. In both groups there were no statistically significant differences in percentage excess weight loss between smokers and nonsmokers, or between those who quit and did not. Conclusions: In the long-term follow-up after laparoscopic adjustable gastric banding, 33% of smokers quit and 17% previously nonsmoking began smoking. After laparoscopic sleeve gastrectomy, 46% of previously smoking patients successfully quit. Smoking status was not significantly associated with weight loss.

Keywords:

Smoking, Obesity, Surgery, Sleeve, Long term

Affiliations:
Kowalewski P.K.-University of Ecology and Management (PL)
Olszewski R.-IPPT PAN
Walędziak M.S.-Military Institute of Medicine (PL)
Janik M.R.-Military Institute of Medicine (PL)
Kwiatkowski A.-Military Institute of Medicine (PL)
Paśnik K.-Military Institute of Medicine (PL)
2.Kowalewski P.K., Olszewski R., Walędziak M.S., Janik M.R., Kwiatkowski A., Gałązka-Świderek N., Cichoń K., Brągoszewski J., Paśnik K., Long-Term Outcomes of Laparoscopic Sleeve Gastrectomy—a Single-Center, Retrospective Study , Obesity Surgery, ISSN: 0960-8923, DOI: 10.1007/s11695-017-2795-2, Vol.28, pp.130-134, 2018
Abstract:

Introduction Sleeve gastrectomy (LSG) is one of the most popularbariatricprocedures.Wepresentourlong-termresults regarding weight loss, comorbidities, and gastric reflux disease. Materialand Methods We identified patients who underwent LSGinourinstitutionbetween2006and2009.Werevisedthe data, and the patients with outdated contact details were tracked with the national health insurance database and social media(facebook).Eachoftheidentifiedpatientswasaskedto complete an online or telephone survey covering, among others, their weight and comorbidities. On that basis, we calculated the percent total weight loss (%TWL) and percent excessweightloss(%EWL),alongwithchangesinbodymass index(ΔBMI).Satisfactoryweightlosswassetat>50%EWL (for BMI = 25 kg/m2). We evaluated type 2 diabetes (T2DM) and arterial hypertension (AHT) based on the pharmacological therapy. GERD presence was evaluated by the typical symptoms and/or proton pump inhibitor (PPI) therapy. Results One hundred twenty-seven patients underwent LSG between 2006 and 2009. One hundred twenty patients were qualified for this study. Follow-up data was available for 100 participants (47 female, 53 male). Median follow-up period reached 8.0 years (from 7.1 to 10.7). Median BMI upon qualification for LSG was 51.6 kg/m2. Sixteen percent of patients required revisional surgery over the years (RS group), mainly because of insufficient weight loss (14 Roux-Y gastric bypass—LRYGB;oneminigastricbypass,onegastricbanding). For the LSG (LSG group n = 84), the mean %EWL was 51.1% (±22.3), median %TWL was 23.5% (IQR 17.7– 33.3%), and median ΔBMI was 12.1 kg/m2 (IQR 8.2–17.2). Fifty percent (n = 42) of patients achieved the satisfactory %EWL of 50%. For RS group, the mean %EWL was 57.8% (±18.2%) and median %TWL reached 33% (IQR 27.7– 37.9%). Sixty-two percent (n = 10) achieved the satisfactory weight loss. Fifty-nine percent of patients reported improvement in AHT therapy, 58% in T2DM. After LSG, 60% (n = 60) of patients reported recurring GERD symptoms and 44% were treated with proton pomp inhibitors (PPI). In 93% of these cases, GERD has developed de novo. Conclusions Isolated LSG provides fairly good effects in a long-term follow-up with mean %EWL at 51.1%. Sixteen percent of patients require additional surgery due to insufficient weight loss. More than half of the subjects observe improvement inAHTand T2DM.Overhalfofthepatientscomplain of GERD symptoms, which in most of the cases is a de novo complaint.

Keywords:

Bariatricsurgery, Sleeve, Long-termfollow-up, Comorbidities, GERD

Affiliations:
Kowalewski P.K.-University of Ecology and Management (PL)
Olszewski R.-IPPT PAN
Walędziak M.S.-Military Institute of Medicine (PL)
Janik M.R.-Military Institute of Medicine (PL)
Kwiatkowski A.-Military Institute of Medicine (PL)
Gałązka-Świderek N.-Regional Hospital, Łęczna (PL)
Cichoń K.-Regional Hospital, Łęczna (PL)
Brągoszewski J.-Military Institute of Medicine (PL)
Paśnik K.-Military Institute of Medicine (PL)
3.Dobkowska-Chudon W., Wrobel M., Karłowicz P., Dabrowski A., Krupienicz A., Targowski T., Nowicki A., Olszewski R., Detecting cerebrovascular changes in the brain caused by hypertension in atrial fibrillation group using acoustocerebrography, PLOS ONE, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0199999, Vol.13, No.7, pp.1-10, 2018
Abstract:

Acoustocerebrography is a novel, non-invasive, transcranial ultrasonic diagnostic method
based on the transmission of multispectral ultrasound signals propagating through the brain
tissue. Dedicated signal processing enables the estimation of absorption coefficient, frequency-
dependent attenuation, speed of sound and tissue elasticity. Hypertension and atrial
fibrillation are well known factors correlated with white matter lesions, intracerebral hemorrhage
and cryptogenic stroke numbers. The aim of this study was to compare the acoustocerebrography
signal in the brains of asymptomatic atrial fibrillation patients with and
without hypertension. The study included 97 asymptomatic patients (40 female and 57
male, age 66.26 ± 6.54 years) who were clinically monitored for atrial fibrillation. The
patients were divided into two groups: group I (patients with hypertension) n = 75, and group
II (patients without hypertension) n = 22. Phase and amplitude of all spectral components
for the received signals from the brain path were extracted and compared to the phase and
amplitude of the transmitted pulse. Next, the time of flight and the attenuation of each frequency
component were calculated. Additionally, a fast Fourier transformation was performed
and its features were extracted. After introducing a machine learning technique, the
ROC plot of differentiations between group I and group II with an AUC of 0.958 (sensitivity
0.99 and specificity 0.968) was obtained. It can be assumed that the significant difference in
the acoustocerebrography signals in patients with hypertension is due to changes in the
brain tissue, and it allows for the differentiating of high-risk patients with asymptomatic atrial
fibrillation and hypertension.

Keywords:

changes in the brain, hypertension in atrial, acoustocerebrography

Affiliations:
Dobkowska-Chudon W.-District Hospital, Radom (PL)
Wrobel M.-Sonovum A.G., Leipzig (DE)
Karłowicz P.-Sonomed Sp. z o.o., Warszawa (PL)
Dabrowski A.-MTZ Clinical Research, Warszawa (PL)
Krupienicz A.-Medical University of Warsaw (PL)
Targowski T.-National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw (PL)
Nowicki A.-IPPT PAN
Olszewski R.-IPPT PAN
4.Gluba-Brzózka A., Franczyk B., Ciałkowska-Rysz A., Olszewski R., Rysz J., Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients, Nutrients , ISSN: 2072-6643, DOI: 10.3390/nu10060709, Vol.10, No.709, pp.1-12, 2018
Abstract:

In patients suffering from chronic kidney disease (CKD), the prevalence of cardiovascular disease is much more common than in the general population. The role of vitamin D deficiency had been underestimated until a significant association was found between vitamin D therapy and survival benefit in haemodialysis patients. Vitamin D deficiency is present even in the early stages of chronic kidney disease. The results of experimental studies have revealed the relationship between vitamin D deficiency and impairment of cardiac contractile function, higher cardiac mass and increased myocardial collagen content. Experimental models propose that intermediate end points for the relationship between vitamin D deficiency and higher risk of cardiovascular disease comprise diminished left ventricular hypertrophy (LVH), enhanced left ventricular diastolic function, anddecreasedfrequencyofheartfailure. Multipleobservationalstudieshavedemonstrated an association between the use of active vitamin D therapy in patients on dialysis and with CKD and improved survival. However, there are also many studies indicating important adverse effects of such treatment. Therefore, large randomized trials are required to analyze whether supplementation of vitamin D may affect outcomes and whether it is safe to be used in CKD patient

Keywords:

vitamin D; chronic kidney disease; cardiovascular disease; mortality; vitamin D analogues; treatment

Affiliations:
Gluba-Brzózka A.-WAM Teaching Hospital, Lodz (PL)
Franczyk B.-Medical University of Lodz (PL)
Ciałkowska-Rysz A.-Medical University of Lodz (PL)
Olszewski R.-IPPT PAN
Rysz J.-Medical University of Lodz (PL)
5.Nowicki A., Trawiński Z., Gambin B., Secomski W., Szubielski M., Parol M., Olszewski R., 20-MHZ ultrasound for measurements offlow-mediated dilation and shear rate in the radialartery, ULTRASOUND IN MEDICINE AND BIOLOGY, ISSN: 0301-5629, DOI: 10.1016/j.ultrasmedbio.2018.02.011, Vol.44, No.6, pp.1187-1197, 2018
Abstract:

A high-frequency scanning system consisting of a 20-MHz linear array transducer combined with a 20-MHz pulsed Dopplerprobe was introduced to evaluate the degree of radial artery flow-mediated dilation (FMD [%]) in two groups of patients after5 min of controlled forearm ischemia followed by reactive hyperemia. In group I, comprising 27 healthy volunteers, FMD (mean ± standard deviation) was 15.26 ± 4.90% (95% confidence interval [CI]: 13.32%–17.20%); in group II, comprising 17 patients with chronic coronary artery disease, FMD was significantly less at 4.53 ± 4.11% (95% CI: 2.42%–6.64%). Specifically, the ratio FMD/SR (mean ± standard deviation),wasequalto5.36×10−4±4.64×10−4 (95%CI:3.54×10−4 to7.18×10−4)ingroupIand1.38×10−4±0.89×10−4 (95% CI: 0.70 × 10−4 to 2.06 × 10−4) in group II. Statistically significant differences between the two groups were confirmed by a Wilcoxon–Mann–Whitney test for both FMD and FMD/SR (p < 0.01). Areas under receiver operating characteristic curves for FMD and FMD/SR were greater than 0.9. The results confirm the usefulness of the proposed measurements of radial artery FMD and SR in differentiation of normal patients from those with chronic coronary artery disease. (E-mail: anowicki@ippt.gov.pl) © 2018 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

Keywords:

Flow-mediated vasodilation, Radial artery, Shear rate, Reactive hyperemia, Endothelium, Pulsed doppler, Ultrasonography

Affiliations:
Nowicki A.-IPPT PAN
Trawiński Z.-IPPT PAN
Gambin B.-IPPT PAN
Secomski W.-IPPT PAN
Szubielski M.-Mazovia Regional Hospital in Siedlce (PL)
Parol M.-The John Paul’s II Western Hospital in Grodzisk Mazowiecki (PL)
Olszewski R.-IPPT PAN
6.Buda N., Kosiak W., Radzikowska E., Olszewski R., Jassem E., Grabczak E.M., Pomiecko A., Piotrkowski J., Piskunowicz M., Sołtysiak M., Skoczyński S., Jaczewski G., Odrowska J., Skoczylas A., Wełnicki M., Wiśniewski J., Zamojska A., Polish recommendations for lung ultrasound in internal medicine (POLLUS-IM), Journal of Ultrasonography, ISSN: 2084-8404, DOI: 10.15557/JoU.2018.0030, Vol.18, pp.198-206, 2018
Abstract:

The aim of this study was to establish recommendations for the use of lung
ultrasound in internal medicine, based on reliable data and expert opinions. Methods:
The bibliography from the databases (Pubmed, Medline, OVID, Embase) has been fully
reviewed up to August 2017. Members of the expert group assessed the credibility of the literature
data. Then, in three rounds, a discussion was held on individual recommendations
(in accordance with the Delphi procedure) followed by secret voting. Results: Thirty-eight
recommendations for the use of lung ultrasound in internal medicine were established
as well as discussed and subjected to secret voting in three rounds. The first 31 recommendations
concerned the use of ultrasound in the diagnosis of the following conditions:
pneumothorax, pulmonary consolidation, pneumonia, atelectasis, pulmonary embolism,
malignant neoplastic lesions, interstitial lung lesions, cardiogenic pulmonary edema, interstitial
lung diseases with fibrosis, dyspnea, pleural pain and acute cough. Furthermore,
seven additional statements were made regarding the technical conditions of lung ultrasound
examination and the need for training in the basics of lung ultrasound in a group of
doctors during their specialization programs and medical students. The panel of experts
established a consensus on all 38 recommendations.

Affiliations:
Buda N.-Medical University of Gdansk (PL)
Kosiak W.-Medical University of Gdansk (PL)
Skoczyński S.-Medical University of Silesia (PL)
Jaczewski G.-Medical University of Warsaw (PL)
Odrowska J.-Folk-Med (PL)
Skoczylas A.-National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw (PL)
Wełnicki M.-Medical University of Warsaw (PL)
Wiśniewski J.-University Clinical Centre in Gdansk (PL)
Zamojska A.-University of Gdansk (PL)
Radzikowska E.-Medical University of Gdansk (PL)
Olszewski R.-IPPT PAN
Jassem E.-Medical University of Gdansk (PL)
Grabczak E.M.-Medical University of Warsaw (PL)
Pomiecko A.-University Clinical Centre in Gdansk (PL)
Piotrkowski J.-Oncology Centre in Olsztyn (PL)
Piskunowicz M.-Medical University of Gdansk (PL)
Sołtysiak M.-other affiliation
7.Kowalewski P.K., Olszewski R., Walędziak M.S., Janik M.R., Kwiatkowski A., Gałązka-Świderek N., Cichoń K., Brągoszewski J., Paśnik K., Long-Term Outcomes of Laparoscopic Sleeve Gastrectomy—a Single-Center, Retrospective Study, Obesity Surgery, ISSN: 0960-8923, DOI: 10.1007/s11695-017-2795-2, pp.1-5, 2017
Abstract:

Introduction Sleeve gastrectomy (LSG) is one of the most
popular bariatric procedures. We present our long-term results
regarding weight loss, comorbidities, and gastric reflux
disease.
Material and Methods We identified patients who underwent
LSG in our institution between 2006 and 2009. We revised the
data, and the patients with outdated contact details were
tracked with the national health insurance database and social
media (facebook). Each of the identified patients was asked to
complete an online or telephone survey covering, among
others, their weight and comorbidities. On that basis, we calculated
the percent total weight loss (%TWL) and percent
excess weight loss (%EWL), along with changes in body mass
index (ΔBMI). Satisfactory weight loss was set at >50% EWL
(for BMI = 25 kg/m2
). We evaluated type 2 diabetes (T2DM)
and arterial hypertension (AHT) based on the pharmacological
therapy. GERD presence was evaluated by the typical
symptoms and/or proton pump inhibitor (PPI) therapy.
Results One hundred twenty-seven patients underwent LSG
between 2006 and 2009. One hundred twenty patients were
qualified for this study. Follow-up data was available for 100
participants (47 female, 53 male). Median follow-up period
reached 8.0 years (from 7.1 to 10.7). Median BMI upon qualification
for LSG was 51.6 kg/m2
. Sixteen percent of patients
required revisional surgery over the years (RS group), mainly
because of insufficient weight loss (14 Roux-Y gastric bypass—LRYGB;
one mini gastric bypass, one gastric banding).
For the LSG (LSG group n = 84), the mean %EWL was
51.1% (±22.3), median %TWL was 23.5% (IQR 17.7–
33.3%), and median ΔBMI was 12.1 kg/m2 (IQR 8.2–17.2).
Fifty percent (n = 42) of patients achieved the satisfactory
%EWL of 50%. For RS group, the mean %EWL was 57.8%
(±18.2%) and median %TWL reached 33% (IQR 27.7–
37.9%). Sixty-two percent (n = 10) achieved the satisfactory
weight loss. Fifty-nine percent of patients reported improvement
in AHT therapy, 58% in T2DM. After LSG, 60%
(n = 60) of patients reported recurring GERD symptoms and
44% were treated with proton pomp inhibitors (PPI). In 93%
of these cases, GERD has developed de novo.
Conclusions Isolated LSG provides fairly good effects in a
long-term follow-up with mean %EWL at 51.1%. Sixteen
percent of patients require additional surgery due to insufficient
weight loss. More than half of the subjects observe improvement
in AHT and T2DM. Over half of the patients complain
of GERD symptoms, which in most of the cases is a de
novo complaint.

Keywords:

Bariatricsurgery, Sleeve, Long-termfollow-up, Comorbidities, GERD

Affiliations:
Kowalewski P.K.-Military Institute of Medicine (PL)
Olszewski R.-IPPT PAN
Walędziak M.S.-Military Institute of Medicine (PL)
Janik M.R.-Military Institute of Medicine (PL)
Kwiatkowski A.-Military Institute of Medicine (PL)
Gałązka-Świderek N.-Regional Hospital, Łęczna (PL)
Cichoń K.-Regional Hospital, Łęczna (PL)
Brągoszewski J.-Military Institute of Medicine (PL)
Paśnik K.-Military Institute of Medicine (PL)
8.Gluba-Brzózka A., Franczyk B., Olszewski R., Banach M., Rysz J., Personalized Medicine: New Perspectives for the Diagnosis and the Treatment of Renal Diseases, International Journal of Molecular Sciences, ISSN: 1422-0067, DOI: 10.3390/ijms18061248, Vol.18, No.1248, pp.1-20, 2017
Abstract:

The prevalence of renal diseases is rising and reaching 5–15% of the adult population. Renal damage is associated with disturbances of body homeostasis and the loss of equilibrium between exogenous and endogenous elements including drugs and metabolites. Studies indicate that renal diseases are influenced not only by environmental but also by genetic factors. In some cases the disease is caused by mutation in a single gene and at that time severity depends on the presence of one or two utated alleles. In other cases, renal disease is associated with the presence of alteration within a gene or genes, but environmental factors are also necessary for the development of disease. Therefore, it seems that the analysis of genetic aspects should be a natural component of clinical and xperimental studies. The goal of personalized medicine is to determine the right drug,for the right patient,at the right time. Whole-genome examinations may help to change the approach to the disease and the patient resulting in the creation of“personalized medicine”with new diagnostic and treatment strategies designed on the basis of genetic background of each individual. The identification of high-risk patients in pharmacogenomics analyses will help to avoid many unwarranted side effects while optimizing treatment efficacy for individual patients. Personalized therapies for kidney diseases are still at the preliminary stage mainly due to high costs of such analyses and the complex nature of human genome. This review will focus on several areas of interest: renal disease pathogenesis, diagnosis, treatment, rate of progression and the prediction ofprognosis.

Keywords:

renal diseases; personalized medicine;treatment;diagnosis;biomarkers

Affiliations:
Gluba-Brzózka A.-WAM Teaching Hospital, Lodz (PL)
Franczyk B.-Medical University of Lodz (PL)
Olszewski R.-IPPT PAN
Banach M.-Medical University of Lodz (PL)
Rysz J.-Medical University of Lodz (PL)
9.Wilczek M.M., Olszewski R., Krupienicz A., Trans -Fatty Acids and Cardiovascular Disease: Urgent Need for Legislation , CARDIOLOGY, ISSN: 0008-6312, DOI: 10.1159/000479956 , Vol.138, No.4, pp.254-258, 2017
Abstract:

Hydrogenated oils containing trans -fatty acids (TFA) are used to produce margarine and various processed foods. TFA affect serum lipid levels, fatty acid metabolism, and endothelial function. High TFA intake is linked to increased allcause mortality, coronary heart disease mortality, and cardiovascular disease (CVD) incidence. Denmark was the first country to introduce a law that limited TFA content in food; this action led to lower CVD mortality. So far 7 European countries have followed this practice, in a few others the food industry voluntarily reduced TFA use. The issue remains mostly unaddressed in the rest of the world. Legal TFA limits should be commonly established as they are the optimal solution considering both CVD prevention and the associated cost savings in public healthcare.

Keywords:

Trans -fatty acids, Cardiovascular disease, Nutrition policy

Affiliations:
Wilczek M.M.-Poznan University of Medical Sciences (PL)
Olszewski R.-IPPT PAN
Krupienicz A.-Medical University of Warsaw (PL)
10.Lejkowski W., Dobrowolski A.P., Gawron B., Olszewski R., Wieloaspektowa Analiza Spektralna Sygnałów Fonokardiograficznych , PRZEGLĄD ELEKTROTECHNICZNY, ISSN: 0033-2097, DOI: 10.15199/48.2017.10.17 , Vol.93, No.10, pp.73-76, 2017
Abstract:

W artykule przedstawiono koncepcję analizy spektralnej sygnałów fonokardiograficznych. Zaprezentowano wyniki analizy sygnałów zawierających od kilku do kilkunastu uderzeń serca oraz sygnałów krótkich zawierających pojedyncze uderzenie serca. Przedstawiono propozycje kilkudziesięciu widmowych cech dystynktywnych oraz ocenę ich przydatności w diagnostyce schorzeń kardiologicznych. (Multifaceted Spectral Analysis of Phonocardiographic Signals)

Keywords:

fonokardiografia, elektrokardiografia, metrologia medyczna, tony serca, analiza spektralna

Affiliations:
Lejkowski W.-Centralny Wojskowy Ośrodek Metrologii (PL)
Dobrowolski A.P.-Military University of Technology (PL)
Gawron B.-Oddział Zabezpieczenia Dowództwa Garnizonu Warszawa (PL)
Olszewski R.-IPPT PAN
11.Majka K., Krupienicz A., Olszewski R., Telepielęgniarstwo w ortopedii, Medycyna Ogólna i Nauki o Zdrowiu, ISSN: 2083-4543, DOI: 10.26444/monz/75509, Vol.23, No.2, pp.94-97, 2017
Abstract:

Wprowadzenie i cel pracy. Rozwój technologii informacyjno-komunikacyjnej może doprowadzić do poprawy sytuacji w służbie zdrowia. Telepielęgniarstwo pozwoli na rozszerzenie praktyki pielęgniarskiej oraz wielu funkcji takich jak: opiekuńczo-pielęgnacyjna, profilaktyczna, diagnostyczna, rehabilitacyjna i związana z promocją zdrowia. Celem pracy jest ukazanie telepielęgniarstwa w ortopedii, a także zaprezentowanie wielu korzyści, jakie niesie zarówno dla pacjenta, jak i dla personelu medycznego. Skrócony opis stanu wiedzy. Starzejące się społeczeństwo potrzebuje zarówno wykwalifikowanego personelu pielęgniarskiego, jak i możliwości uzyskania szybkiej konsultacji lekarskiej i pielęgniarskiej. Udzielanie wskazówek, porad i opieki pielęgniarskiej przez pielęgniarki specjalistki w swej profesji m.in. za pomocą wideokonferencji przysporzy znaczących korzyści zarówno pacjentom, lekarzom, pielęgniarkom, jak i rehabilitantom. Podsumowanie. Wdrożenie wirtualnych wizyt może doprowadzić do poprawy sytuacji w ochronie zdrowia. Telepielęgniarstwo rozszerzyłoby kompetencje pielęgniarki, a także podniosłoby jakość świadczonych przez nie usług. Być może zatrzymałoby również emigrację zarobkową pielęgniarek w Polsce.

Keywords:

telepielęgniarstwo, ortopedia, edukacja pacjenta, nowe technologie, kształcenie, niedobór personelu pielęgniarskiego

Affiliations:
Majka K.-Military Medical Institute (PL)
Krupienicz A.-Medical University of Warsaw (PL)
Olszewski R.-IPPT PAN
12.Secomski W., Wójcik J., Klimonda Z., Olszewski R., Nowicki A., Influence of absorption and scattering on the velocity of acoustic streaming, HYDROACOUSTICS, ISSN: 1642-1817, Vol.20, No.1, pp.159-166, 2017
Abstract:

Streaming velocity depends on intensity and absorption of ultrasound in the media. In some cases, such as ultrasound scattered on blood cells at high frequencies, or the presence of ultrasound contrast agents, scattering affects the streaming speed. The velocities of acoustic streaming in a blood-mimicking starch suspension in water and Bracco BR14 contrast agent were measured. The source of the streaming was a plane 20MHz ultrasonic transducer. Velocity was estimated from the averaged Doppler spectrum. The single particle driving force was calculated as the integral of the momentum density tensor components. For different starch concentrations, the streaming velocity increased from 8.9 to 12.5mm/s. This corresponds to a constant 14% velocity increase for a 1 g/l increase in starch concentration. For BR14, the streaming velocity remained constant at 7.2mm/s and was independent of the microbubbles concentration. The velocity was less than in reference, within 0.5mm/s measurement error. Theoretical calculations showed a 16% increase in streaming velocity for 1 g/l starch concentration rise, very similar to the experimental results. The theory has also shown the ability to reduce the streaming velocity by low-density scatterers, as was experimentally proved using the BR14 contrast agent.

Keywords:

ultrasound, radiation force, starch, contrast agent, blood, thrombolysis

Affiliations:
Secomski W.-IPPT PAN
Wójcik J.-IPPT PAN
Klimonda Z.-IPPT PAN
Olszewski R.-IPPT PAN
Nowicki A.-IPPT PAN
13.Kowalewski P.K., Olszewski R., Kwiatkowski A., Gałązka-Świderek N., Cichoń K., Paśnik K., Life with a Gastric Band. Long-Term Outcomes of Laparoscopic Adjustable Gastric Banding—a Retrospective Study, Obesity Surgery, ISSN: 0960-8923, DOI: 10.1007/s11695-016-2435-2, Vol.27, pp.1250-1253, 2016
Abstract:

Background: Laparoscopic adjustable gastric banding (LAGB) is the third most popular bariatric procedure worldwide. Various authors present ambivalent long-term follow up results. Methods: We revised records of the patients who underwent LAGB between 2003 and 2006 along with history of additional check-ins. Patients with outdated details were tracked with the national health insurance database and social media (Facebook). An online survey was sent. The patients who did not have their band removed were included in this study. We calculated the percent total weight loss (%TWL) and percent excess weight loss (%EWL), along with changes in body mass index (ΔBMI). Satisfactory weight loss was set at >50% EWL (for BMI = 25 kg/m(2)). Since eight patients gained weight, we decided to include negative values of %TWL, %EWL, and ΔBMI. Results: One hundred seven patients underwent LAGB from 2003 to 2006. The mean follow-up time was 11.2 (±1.2) years. Eleven percent of patients were lost to follow up (n = 12). There was one perioperative death. Fifty-four of the patients (n = 57) had their band removed. Thirty-seven patients still have the band (39%) and were included in the study. The mean %EWL was 27% (-56-112%) and %TWL was 11% (-19-53%). Twelve patients achieved %EWL > 50% (32%). Thiry-two patients still suffer from obesity, with BMI over 30 kg/m(2). Eight patients (22%) gained additional weight. Patients with %EWL > 50% suffered less from gastroesophageal reflux disease symptoms than those with EWL < 50% (p < 0.05). Conclusions: Out of 107 cases, only 11.2% of patients with gastric band (n = 12) achieved satisfactory %EWL. Twenty-two percent of patients regained their weight or even exceeded it. Overall results suggest that LAGB is not an effective bariatric procedure in long term observation.

Life with a Gastric Band. Long-Term Outcomes of Laparoscopic Adjustable Gastric Banding—a Retrospective Study (PDF Download Available). Available from: https://www.researchgate.net/publication/309486095_Life_with_a_Gastric_Band_Long-Term_Outcomes_of_Laparoscopic_Adjustable_Gastric_Banding-a_Retrospective_Study [accessed Dec 05 2017].

Keywords:

Laparoscopy, Bariatric surgery, LAGB, Gastric band, Long term follow-up

Affiliations:
Kowalewski P.K.-Military Institute of Medicine (PL)
Olszewski R.-other affiliation
Kwiatkowski A.-Military Institute of Medicine (PL)
Gałązka-Świderek N.-Regional Hospital, Łęczna (PL)
Cichoń K.-Regional Hospital, Łęczna (PL)
Paśnik K.-Military Institute of Medicine (PL)
14.Nowicki A., Secomski W., Trawiński Z., Lewandowski M., Trots I., Szubielski M., Olszewski R., Estimation of radial artery reactive response using high frequency ultrasound, HYDROACOUSTICS, ISSN: 1642-1817, Vol.19, pp.297-306, 2016
Abstract:

Background:
There is a growing interest in the application of non-invasive clinical tools allowing one to assess the endothelial function, preceding atherosclerosis. The precision in estimating of the artery Flow Mediated Vasodilation (FMD) using standard 10-12 MHz linear array probes does not exceed 0.2 mm, far beyond that required.

Methods:
We have introduced a wide-band, high frequency 25-30 MHz, Golay encoded wobbling type imaging to measure dilation of the radial artery instead of the brachial one. 18 young volunteers, and 4 volunteers with cardiac events history, were examined. In the second approach 20 MHz linear scanning combined with 20 MHz pulsed Doppler attached to the linear array was used. The radial artery FMD was normalized using shear rate at the radial artery wall.

Results and Conclusions:
For the “healthy” group, the FMD resulting from reactive hyperemia response was over 20%; while in the “atherosclerotic” group, the FMD was at least twice as small, not exceeding 10%. The shear rate (SR) normalized FMDSR was in the range from 7.8 to 9.9 in arbitrary units, while in patients with minor cardiac history FMDSR was clearly lower, 6.8 to 7.6. The normalized FMDSR of radial artery RARR can be an alternative to the brachial FMD where the precision of measurements is lower and the diameter dilation does not exceed 7-10%.

Keywords:

thick film transducers, atherosclerosis, flow mediated vasodilation

Affiliations:
Nowicki A.-IPPT PAN
Secomski W.-IPPT PAN
Trawiński Z.-IPPT PAN
Lewandowski M.-IPPT PAN
Trots I.-IPPT PAN
Szubielski M.-Mazovia Regional Hospital in Siedlce (PL)
Olszewski R.-IPPT PAN
15.Trawiński Z., Wójcik J., Nowicki A., Olszewski R., Balcerzak A., Frankowska E., Zegadło A., Rydzyński P., Strain examinations of the left ventricle phantom by ultrasound and multislices computed tomography imaging, Biocybernetics and Biomedical Engineering, ISSN: 0208-5216, DOI: 10.1016/j.bbe.2015.03.001, Vol.35, pp.255-263, 2015
Abstract:

The main aim of this study was to verify the suitability of the hydrogel sonographic model of the left ventricle (LV) in the computed tomography (CT) environment and echocardiography and compare the radial strain calculations obtained by two different techniques: the speckle tracking ultrasonography and the multislices computed tomography (MSCT). The measurement setup consists of the LV model immersed in a cylindrical tank filled with water, hydraulic pump, the ultrasound scanner, hydraulic pump controller, pressure measurement system of water inside the LV model, and iMac workstation. The phantom was scanned using a 3.5 MHz Artida Toshiba ultrasound scanner unit at two angle positions: 0° and 25°. In this work a new method of assessment of RF speckles’ tracking. LV phantom was also examined using the CT 750 HD 64-slice MSCT machine (GE Healthcare). The results showed that the radial strain (RS) was independent on the insonifying angle or the pump rate. The results showed a very good agreement, at the level of 0.9%, in the radial strain assessment between the ultrasound M-mode technique and multislice CT examination. The study indicates the usefulness of the ultrasonographic LV model in the CT technique. The presented ultrasonographic LV phantom may be used to analyze left ventricle wall strains in physiological as well as pathological conditions. CT, ultrasound M-mode techniques, and author's speckle tracking algorithm, can be used as reference methods in conducting comparative studies using ultrasound scanners of various manufacturers.

Keywords:

Computed tomography, Echocardiography, Left ventricle, Speckles tracking, Strain, Ultrasound phantoms

Affiliations:
Trawiński Z.-IPPT PAN
Wójcik J.-IPPT PAN
Nowicki A.-IPPT PAN
Olszewski R.-other affiliation
Balcerzak A.-IPPT PAN
Frankowska E.-Military Medical Institute (PL)
Zegadło A.-other affiliation
Rydzyński P.-other affiliation
16.Trawiński Z., Wójcik J., Nowicki A., Balcerzak A., Olszewski R., Frankowska E., Zegadło A., Rydzyński P., Assessment of left ventricle phantom wall compressibility by ultrasound and computed tomography methods, HYDROACOUSTICS, ISSN: 1642-1817, Vol.17, pp.211-218, 2014
Abstract:

The present work concerns the sonographic model of the left ventricle (LV) examined in the Computed Tomography (CT) environment and compare radial strain calculations obtained by two different techniques: the speckle tracking ultrasonography and the Multislices Computed Tomography (MSCT). The Left Ventricular (LF) phantom was fabricated from 10% solution of the poly(vinyl alcohol) (PVA). Our model of the LV was driven by the computer- controlled hydraulic piston Super -Pump (Vivitro Inc., Canada) with adjustable fluid volumes. The stroke volume was set at of 24ml. The fluid pressure was changed within range of 0- 60 mmHg, and the pulse rate was of 60 cycles/per minute. The relationships between computer controlled left ventricular wall deformations and its visual izations of the echocardiographic and CT imaging, both in the normal and pathological conditions were examined. The difference of assessment the Radial Strain between two methods was not exceeding 1.1%.

Affiliations:
Trawiński Z.-IPPT PAN
Wójcik J.-IPPT PAN
Nowicki A.-IPPT PAN
Balcerzak A.-IPPT PAN
Olszewski R.-other affiliation
Frankowska E.-Military Medical Institute (PL)
Zegadło A.-other affiliation
Rydzyński P.-other affiliation
17.Trawiński Z., Wójcik J., Nowicki A., Olszewski R., Dynamic Ultrasonic Model of Left Ventricle, HYDROACOUSTICS, ISSN: 1642-1817, Vol.16, pp.231-236, 2013
Abstract:

Two different tissue phantoms of the left ventricle to imitate a beating left ventricle were developed: first was prepared using a sponge material and second phantom was constructed using a polyvinyl alcohol material modeled into a homogeneous hollow cylinder: approximately 10 cm and 12 cm in length for the first and second phantom, respectively. Both phantoms were 5 cm in diameter, with a wall thickness of 1.0 cm. Additionally, a small part of the wall of the second phantom was processed to simulate the stiffness of myocardial infarction. The phantoms were connected at the end to an adjustable external pump. The pulse volume inside the cylinder was set between 12 to 50 ml at rates of 40, 60, 100, 120 beats/minute. The phantoms were immersed in water for ultrasound scanning with two different insonation angles (90 and 65 degrees). Strain and strain rate were measured with different combinations of angles and pulse rates. The main aim of this work was to develop the new method for validation of the human infarct wall strain calculation procedures using the speckles tracking.

Keywords:

soft tissue, phantom, ultrasound

Affiliations:
Trawiński Z.-IPPT PAN
Wójcik J.-IPPT PAN
Nowicki A.-IPPT PAN
Olszewski R.-other affiliation
18.Olszewski R., Trawiński Z., Wójcik J., Nowicki A., Mathematical and Ultrasonographic Model of the Left Ventricle:in Vitro Studies, ARCHIVES OF ACOUSTICS, ISSN: 0137-5075, Vol.37, No.4, pp.583-595, 2012
Abstract:

The main objective of this study is to develop an echocardiographic model of the left ventricular and numerical modeling of the speckles- markers tracking in the ultrasound (ultrasonographic) imaging of the left ventricle. The work is aimed at the creation of controlled and mobile environment that enables to examine the relationships between left ventricular wall deformations and visualizations of these states in the form of echocardiographic imaging and relations between the dynamically changing distributions of tissue markers of studied structures.

Keywords:

left ventricle, echocardiography, speckle modeling, ultrasound phantoms, strain, strain rate

Affiliations:
Olszewski R.-other affiliation
Trawiński Z.-IPPT PAN
Wójcik J.-IPPT PAN
Nowicki A.-IPPT PAN
19.Secomski W., Nowicki A., Tortoli P., Olszewski R., Multigate Doppler measurements of ultrasonic attenuation and blood hematocrit in human arteries, ULTRASOUND IN MEDICINE AND BIOLOGY, ISSN: 0301-5629, DOI: 10.1016/j.ultrasmedbio.2008.08.009, Vol.35, No.2, pp.230-236, 2009
Abstract:

A clinically applicable method for noninvasive measurement of hematocrit based on 20 MHz multigate Doppler ultrasound was developed. The ultrasound attenuation coefficient in blood is obtained by measuring the power of the signal coming from gates at different depths. A robust averaging method is introduced, which provides stable and repeatable results by using the echo signals from all depths inside the vessel. In vitro measurements have been done on porcine blood with hematocrit ranging from 3.0% to 65.0%. Steady and pulsatile flow conditions have been simulated using a peristaltic pump. The attenuation coefficient indicated the linear relation to hematocrit. The resulting correlation coefficient was R=0.999 for the continuous blood flow and R=0.992 for pulsatile flow. In vivo measurements have been performed in the brachial artery in 43 patients with hematocrit in the range of 32.0% to 49.3%. The mean absolute error has been 3.24% with a standard deviation of 3.72%.

Keywords:

blood, hematocrit, Doppler, ultrasonic attenuation

Affiliations:
Secomski W.-IPPT PAN
Nowicki A.-IPPT PAN
Tortoli P.-other affiliation
Olszewski R.-other affiliation

Conference papers
1.Secomski W., Klimonda Z., Majka K., Olszewski R., Nowicki A., Sonothrombolysis - Dissolving Thrombi by Interaction of the Drug and Ultrasound, IEEE 2018, IEEE Joint Conference - Acoustics, 2018-09-11/09-14, Ustka (PL), DOI: 10.1109/ACOUSTICS.2018.8502412 , pp.290-293, 2018
Abstract:

Under the influence of pathological changes, the blood coagulates inside the blood vessel, creating a thrombus. The thrombus dissolution process is called thrombolysis. The aim of the study is to evaluate the thrombolysis process by the interaction of the thrombolitic drug and ultrasound. The clot dissolution process was analyzed in a specially designed, transparent for ultrasound parallel plate flow chamber. Inside, a freshly coagulated human blood sample was exposed to ultrasound. A liquid containing the tissue plasminogen activator drug in a concentration of 10 μg/ml passed around the sample. The liquid flow was forced by a peristaltic pump. The source of ultrasound was a 1 MHz flat ultrasonic transducer with a 25 mm diameter. The transducer radiated a 1000 periods burst, repeated every 2500 periods and space averaged time averaged intensities of 0.2-1.6 W/cm2. The efficacy of thrombus dissolution was observed by means of a designed parallel plate flow chamber and the time of thrombus complete dissolution was measured. The best result for the 1 MHz frequency and space averaged time averaged intensity of 1.6 W/cm2 was recorded, where the thrombus was dissolved within 5.5 minutes.

Keywords:

ultrasound, blood, thrombus, thrombolysis, parallel plate flow chamber,

Affiliations:
Secomski W.-IPPT PAN
Klimonda Z.-IPPT PAN
Majka K.-Military Medical Institute (PL)
Olszewski R.-IPPT PAN
Nowicki A.-IPPT PAN
2.Secomski W., Klimonda Z., Majka K., Olszewski R., Nowicki A., Microscopic examination of the sonothrombolysis process inside the transparent to ultrasound parallel plate flow chamber, IUS 2018, 2018 IEEE International Ultrasonics Symposium, 2018-10-22/10-25, KOBE (JP), pp.1-4, 2018
Abstract:

Parallel plate flow chambers are widely used for cell research in conditions of constant or pulsatile liquid flow. They are also used to analyze the formation of thrombi. The authors designed a flow chamber that is transparent to ultrasound, thus enabling the microscopic observation of the thrombus dissolution process by interaction of drug, microbubbles and ultrasound in real time, in-vitro.
Sonothrombolysis was performed at 1 MHz and 3.3 MHz ultrasound frequencies, at space-averaged and time-averaged intensities ISATA of 0.2 – 1.6 W/cm2. 1 mm thick slices of the human blood clots were exposed to ultrasound in the presence of the Actilyse tissue plasminogen activator at a concentration of 10 μg/ml flowing around the sample. Next, the effect of SonoVue microbubbles at a concentration of 5x105/ml on the dissolution of the thrombus was investigated. Thrombus size changes were observed under a 4x magnification microscope and were recorded as a function of time.
The best result was achieved for the Actilyse tissue plasminogen activator at the 1 MHz and 1.6 W/cm2 ISATA, the thrombus was sonolysed within 5.5 minutes. The noticeable effect of the SonoVue microbubbles on the thrombolysis process appeared at 3.3 MHz, the thrombus was sonolysed in 12 min at ISATA = 1.6 W/cm2.

Keywords:

ultrasound, blood, thrombus, thrombolysis, parallel plate flow chamber

Affiliations:
Secomski W.-IPPT PAN
Klimonda Z.-IPPT PAN
Majka K.-Military Medical Institute (PL)
Olszewski R.-IPPT PAN
Nowicki A.-IPPT PAN
3.Nowicki A., Gambin B., Trawiński Z., Secomski W., Szubielski M., Tymkiewicz R., Olszewski R., Radial Artery Reactive Response And Shear Rate Measurements Using 20 MHz System, IUS 2018, 2018 IEEE International Ultrasonics Symposium, 2018-10-22/10-25, KOBE (JP), pp.1-4, 2018
Abstract:

The article attempts to select an ultrasound system to assess of endothelium dysfunction-dependent flow mediated dilation (FMD) and shear rate (SR) in radial artery after several minutes of hyperaemia. Methods: We compare the effective axial resolution and Doppler sensitivity of the standard US working below 12 MHz and high frequency (close to 20 MHz) scanning systems measuring the vessel diameter and blood flow measurements in radial arteries. FMD and FMD and SR were measured in Control group of 14 healthy volunteers, and in 13 with stable coronary artery diseases (CAD). Results: In a laboratory experiment of imaging two closely spaced food plastic foils, over three times better axial resolution was demonstrated for the 20 MHz ultrasound system in which the resolution was close to 0.1 mm. Also the sensitivity of the external single 20 MHz pulse Doppler transducer proved to be over 20 dB better (in terms of signalto-noise ratio) than the pulse Doppler incorporated into the L14-5 linear array. FMD in Control group was in the range of 8÷16% with mean±sd equal to 12.13 ± 2.34%; in CAD group FMD was in the range of 0.1÷7 % with mean±sd equal to 3.01±2.18% which was significantly less. FMD/SR was equal to 3.08 ± 1.34 × 10–4 in Control group and 1.01 ± 0.76 × 10–4 in CAD group with ranges equal to 1.66 ÷ 7.8× 10–4 and 0.4 ÷ 2.4× 10–4, respectively. Conclusions: Increasing scanning and Doppler mode frequency to 20 MHz improved the precision of FMD and SR measurements. Statistically significant differences between the two groups were confirmed by statistical tests for FMD and FMD/SR with p-values < 0.05. The results obtained suggest the usefulness of the proposed ultrasonic system for measurements of FMD and SR in the radial artery to differentiate normal subjects from those with CAD.

Keywords:

radial artery; shear rate; reactive hyperaemia; endothelium, pulsed Doppler

Affiliations:
Nowicki A.-IPPT PAN
Gambin B.-IPPT PAN
Trawiński Z.-IPPT PAN
Secomski W.-IPPT PAN
Szubielski M.-Mazovia Regional Hospital in Siedlce (PL)
Tymkiewicz R.-IPPT PAN
Olszewski R.-IPPT PAN
4.Nowicki A., Trawiński Z., Gambin B., Secomski W., Szubielski M., Parol M., Olszewski R., Measurements of Flow Mediated Dilation and Shear Rate in the Radial Artery Using 20 MHz Ultrasonic System in Patients with Coronary Artery Disease., XXI Międzynarodowy Kongres Polskiego Towarzystwa Kardiologicznego, 2017-09-21/09-23, Katowice (PL), pp.1, 2017
Abstract:

A novel high-frequency scanning system, with a 20-MHz linear array transducer combined with 20-MHz pulsed Doppler, was introduced to evaluate the degree of radial artery flow-mediated dilation (FMD) and shear rate (SR)-normalized FMD (FMD/SR) after 5 min of reactive hyperaemia. In group I, comprising 27 healthy volunteers, FMD was 15 ± 4.8%, and in group II, comprising 17 patients with coronary artery disease, FMD was significantly smaller, being equal to 4.6 ± 4%. FMD/SR was equal to 5.365 ± 4.835·10-4 in group I and 1.3 ± 0.89·10-4 in group II. Statistically significant differences between the two groups were confirmed by Wilcoxon-Mann-Whitney test for FMD and FMD/SR (p-values < 0.01). AUCs of ROC curves for FMD and FMD/SR were greater than 0.9. The results confirm the usefulness of the proposed measurements of radial artery FMD and SR in differentiation of normal subjects from those with atherosclerotic lesions.

Keywords:

flow mediated vasodilation, radial artery, shear rate, reactive hyporaemia, endothelium, pulsed Doppler, ultrasonography.

Affiliations:
Nowicki A.-IPPT PAN
Trawiński Z.-IPPT PAN
Gambin B.-IPPT PAN
Secomski W.-IPPT PAN
Szubielski M.-Mazovia Regional Hospital in Siedlce (PL)
Parol M.-The John Paul’s II Western Hospital in Grodzisk Mazowiecki (PL)
Olszewski R.-IPPT PAN
5.Nowicki A., Secomski W., Trawiński Z., Lewandowski M., Olszewski R., Estimation of Flow Mediated Vasodilation of the Radial Artery, IUS 2015, IEEE International Ultrasonics Symposium, 2015-10-21/10-24, Taipei (TW), DOI: 10.1109/ULTSYM.2015.0392, pp.1-4, 2015
Abstract:

Preceding atherosclerosis is endothelial dysfunction. There is therefore interest in the application of non-invasive clinical tools to assess endothelial function. There are commercially available ultrasound scanners to measure flow-mediated vasodilatation (FMD) of the brachial artery using 10-12 MHz linear array probes, however the attainable precision in estimating the changes in artery dilation does not exceeds 0.2 mm, far beyond the required one. We have introduced a high frequency scanning schemes 25-35MHz encoded (Golay) wobbling type imaging without Doppler (uScan developed in our lab, thick film wide bandwidth transducer, 50 microns axial resolution) and 20 MHz ultrasound (Ultrasonix) with 20 MHz pulsed Doppler attached to the linear array. The FMD results were normalized using AUC of shear rate at the radial artery wall.

Keywords:

thick-film transducers, flow-mediated vasolidation, radial artery, shear rate

Affiliations:
Nowicki A.-IPPT PAN
Secomski W.-IPPT PAN
Trawiński Z.-IPPT PAN
Lewandowski M.-IPPT PAN
Olszewski R.-other affiliation
6.Trawiński Z., Wójcik J., Nowicki A., Balcerzak A., Olszewski R., Frankowska E., Zegadło A., Rydzyński P., Evaluation of Left Ventricle Phantom by Ultrasound and Multislices Computer Tomography Imaging, FA2014, 7th FORUM ACUSTICUM 2014, 2014-09-07/09-12, Kraków (PL), No.R24_4, pp.1-5, 2014
Abstract:

The main goal of this study was to verify the suitability of sonographic model of the left ventricle (LV) in Computed Tomography (CT) environment and compare radial strain calculations obtained by two different techniques: speckle tracking ultrasonography and Multislices Computed Tomography (MSCT). The Left Ventricular (LF) phantom was fabricate from 10% solution of the poly(vinyl alcohol) (PVA). Our model of the LV was driven by the computer-controlled hydraulic piston Super-Pump (Vivitro Inc., Canada) with adjustable fluid volumes. During cycle of the pump, the Stroke Volume (SV) of water was pumped into the LV phantom and returned to the pump, resulting in changing the inner and outer diameters of the phantom. The stroke volume was set at of 24ml. The fluid pressure was changed within range of 0-60 mmHg, and the pulse rate was equal 60 cycles/per minute. The relationships between computer controlled left ventricular wall deformations and its visualizations of the echocardiographic and CT imaging, both in the normal and pathological conditions were examined. The difference of assessment the Radial Strain between two methods was not exceeding 1.1%.

Affiliations:
Trawiński Z.-IPPT PAN
Wójcik J.-IPPT PAN
Nowicki A.-IPPT PAN
Balcerzak A.-IPPT PAN
Olszewski R.-other affiliation
Frankowska E.-Military Medical Institute (PL)
Zegadło A.-other affiliation
Rydzyński P.-other affiliation

Conference abstracts
1.Secomski W., Klimonda Z., Majka K., Olszewski R., Nowicki A., Microscopic examination of the sonothrombolysis process inside the transparent to ultrasound parallel plate flow chamber, IUS 2018, 2018 IEEE International Ultrasonics Symposium, 2018-10-22/10-25, KOBE (JP), pp.754-754, 2018
Abstract:


Affiliations:
Secomski W.-IPPT PAN
Klimonda Z.-IPPT PAN
Majka K.-Military Medical Institute (PL)
Olszewski R.-IPPT PAN
Nowicki A.-IPPT PAN
2.Nowicki A., Gambin B., Trawiński Z., Secomski W., Szubielski M., Parol M., Olszewski R., Radial Artery Reactive Response And Shear Rate Measurements Using 20 MHz System, IUS 2018, 2018 IEEE International Ultrasonics Symposium, 2018-10-22/10-25, KOBE (JP), pp.857-857, 2018
3.Olszewski R., Szubielski M., Parol M., Gambin B., Secomski W., Trawiński Z., Nowicki A., Are radial artery flow mediation dilatation and shear rate the new imaging biomarkers in patients with stage B heart failure?, World Congress on Acute Heart Failure, 2018-05-26/05-29, Vienna (AT), DOI: 10.1002/ejhf.1197, Vol.20 (S1), pp.568, 2018
4.Olszewski R., Dobkowska-Chudon W., Wrobel M., Karlowicz P., Dabrowski A., Krupienicz A., Targowski T., Nowicki A., Is Acoustocerebrography a new noninvasive method for early detection of the brain changes in patients with hypertension?, ESC Congress 2017, European Society of Cardiology Congress 2017, 26-30 August, Barcelona, Spain, 2017-08-26/08-30, Barcelona (ES), DOI: 10.1093/eurheartj/ehx501.P190, Vol.38, No.suppl_1, pp.36, 2017
Abstract:

Background: Hypertension (HT) is the leading cause of global disease burden and overall health loss. The brain is one of the main target organs affected by HT. HT is a potentially modifiable risk factor that leads to the formation of large vessel macroangiopathy, small vessel disease, microangiopathy, and microhemorrhages. Early detection of the brain changes (BC) gives a chance to receive appropriate treatment and protection from irreversible damage. Acoustocerebrography (ACG) is a set of techniques to capture the states of human brain tissue, and its changes on its molecular and cellular level. It is based on noninvasive measurements of various parameters obtained by analyzing an ultrasound pulse emitted across the human's skull. The main idea of this method relies in the relation between the tissue density, bulk modulus, and speed of propagation, for ultrasound waves in this medium. In our previous studies we showed that ACG is an effective method for detecting white matter lesions compared to the Magnetic Resonance Imaging. Additionally we showed that ACG allows to obtain a differentiated signal originates from atrial fibrillation (AF) patients and high-risk patients wit AF and HT.

Aim: The aim of the study was early detection of the BC in patients with HT using ACG.

Methods: The study included 136 female and 98 male patients (age 43.6±15.7 years) who were surveyed in the clinical research. The patients were divided into two groups: group I (patients with HT) n=33, and control group II (patients without HT) n=201. Phase and amplitude of all frequency components of the received signals from the brain path were extracted and compared to the phase and amplitude of the transmitted pulse. By doing so, the time of flight and the attenuation of each frequency component were calculated. Additionally, a fast Fourier transformation (FFT) was performed and its features were extracted.

Results: After introducing a machine learning technique, the ROC plot with an AUC of 0.929 with sensitivity 0.879 and specificity 0.831 was obtained (Fig. 1).
Conclusion: ACG is new promising method, which allows for early detection of change in the brain in the patients with HT.

Affiliations:
Olszewski R.-IPPT PAN
Dobkowska-Chudon W.-District Hospital, Radom (PL)
Wrobel M.-Sonovum A.G., Leipzig (DE)
Karlowicz P.-Sonomed Sp. z o.o., Warszawa (PL)
Dabrowski A.-MTZ Clinical Research, Warszawa (PL)
Krupienicz A.-Medical University of Warsaw (PL)
Targowski T.-National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw (PL)
Nowicki A.-IPPT PAN
5.Nowicki A., Lewandowski M., Trots I., Olszewski R., High Frequency Thick Film Ultrasonic Transducers Used for Estimation of Flow-Mediated Vasodilation of the Radial Artery, SENSORDEVICES 2015, 6th International Conference on Sensor Device Technologies and Applications, 2015-08-23/08-28, Wenecja (IT), pp.99-100, 2015
Abstract:

Preceding atherosclerosis is an endothelial dysfunction. Therefore there is a growing interest in the application of non - invasive clinical tools to assess endothelial function. Commercially available ultrasound machines can measure flow - mediated vasodilatation of the brachial artery using maximum 10-12 MH z linear probes. The higher the probe frequency, the better the axial resolution. Recently, a new technology of piezoelectric transducers based on PZT thick film technology has been developed in Meggitt (Denmark) as a response to a call for devices working at higher frequencies. The thick films exhibited at least 30% bandwidth broadening comparing to the standard PZ 27 transducers, resulting in an increase in match filtering encoding output by a factor of 1.4 - 1.5 and finally resulting in a signal to noise gain of the same order. The introduction of a high frequency 25 - 30 MHz ultrasound scanner to measure radial artery diameter after reactive hyperemia open s a new window for more precise imaging of endothelial function.

Keywords:

thick film transducers, atherosclerosis, flow mediated vaso dilation

Affiliations:
Nowicki A.-IPPT PAN
Lewandowski M.-IPPT PAN
Trots I.-IPPT PAN
Olszewski R.-other affiliation
6.Secomski W., Olszewski R., Bilmin K., Nowicki A., Kujawska T., Grieb P., Terapeutyczne wykorzystanie ultradźwięków – wspomaganie procesu rozpuszczania skrzeplin oraz stymulacja apoptozy komórek nowotworowych, XIX Krajowa Konferencja Biocybernetyka i Inżynieria Biomedyczna, 2015-10-14/10-16, Warszawa (PL), pp.59, 2015
Abstract:

Ultradźwięki są stosowane w medycynie zarówno w diagnostyce - ultrasonografii jak i w terapii. Działanie terapeutyczne sprowadza się do efektów termicznych, uśmiercania komórek przez apoptozę oraz efektów sonomechanicznych. Terapie in-vivo są poprzedzane testami in-vitro komórek umieszczonych na szalce Petriego. W tej pracy zostaną przedstawione dwa efekty oddziaływania fali akustycznej na komórki: wspomaganie rozpuszczania skrzepliny oraz apoptoza komórek nowotworowych.
Do badań przygotowano zbiornik wypełniony odgazowaną wodą destylowaną z termostatem i mieszadłem elektromagnetycznym. W zbiorniku umieszczono płaski przetwornik ultradźwiękowy, promieniujący do góry, w kierunku zanurzonej w wodzie szalki Petriego ze skrzepliną lub komórkami.
W pierwszej części oddziaływano falą ultradźwiękową o częstotliwości 1.0 MHz i natężeniu Isata = 0.2 W/cm2 na skrzeplinę uzyskaną z kropli krwi 30 min po pobraniu. Skrzeplinę umieszczono w roztworze soli fizjologicznej z dodatkiem leku rozpuszczającego skrzeplinę tPA typu Actilyse 50 w stężeniu 10μg/ml i nadźwiękawiano przez 20 min. Eksperyment powtórzono z kolejnymi skrzeplinami stosując same ultradźwięki oraz sam lek Actilyse. Współdziałanie leku i fali ultradźwiękowej w ciągu 20 min spowodowało całkowite rozpuszczenie skrzepliny. W pozostałych przypadkach skrzeplina pozostała zmniejszając swoją objętość o 10-20%.
W drugiej części badano wpływ fali ultradźwiękowej 1.0 MHz na komórki nowotworowe szczurzego glejaka C6. Komórki wysiano na dnie szalki i hodowano w pożywce DMEM w temperaturze 37ºC. Następnie do pożywki dodano 1mM kwasu 5-aminolewulinowego ALA. Po 24h inkubacji, komórki poddano działaniu ultradźwięków o natężeniu Isata = 0.4, 0.8 oraz 1.2 W/cm2 przez 3 min. Po kolejnych 24h, żywotność komórek zbadano spektrofotometrem po dodaniu do pożywki odczynnika MTT assay. Badania powtórzono dla komórek bez ALA oraz bez ultradźwięków. Dla natężenia Isata = 1.2 W/cm2, żywotność komórek wynosiła 39% dla współdziałania ALA i ultradźwięków, 78% dla ALA oraz 99% dla ultradźwięków.
Przygotowane przez autorów stanowisko pomiarowe umożliwia prowadzenie badań in-vitro nad terapeutycznym oddziaływaniu ultradźwięków na komórki. Uzyskano pozytywne rezultaty w wykorzystaniu ultradźwięków zarówno do rozpuszczania skrzeplin – sonotrombolizy jak i uśmiercania komórek nowotworowych – terapii sonodynamicznej. Stosowano ultradźwięki małej mocy, niepowodujące zniszczenia komórek przez przegrzanie lub kawitację.

Keywords:

ultradźwięki terapeutyczne, sonotromboliza, tromboliza, leczenie nowotworów

Affiliations:
Secomski W.-IPPT PAN
Olszewski R.-other affiliation
Bilmin K.-Mossakowski Medical Research Centre, Polish Academy of Sciences (PL)
Nowicki A.-IPPT PAN
Kujawska T.-IPPT PAN
Grieb P.-Mossakowski Medical Research Centre, Polish Academy of Sciences (PL)
7.Frankowska E., Trawiński Z., Zegadło A., Olszewski R., Nowicki A., Bogusławska R., Assessment of radial strain in ultrasonographic model of left ventricle using speckle tracking ultrasound technique and multislice computed tomography, ECR 2014, European Congress of Radiology, 2014-03-06/03-10, Wiedeń (AT), DOI: 10.1594/ecr2014/C-0473, Vol.C-0473, pp.1-7, 2014
Abstract:

The aim of this study was to verify suitability of sonographic model of LV (left ventricle) in CT (computed tomography) environment and to compare in vitro radial strain calculations obtained by two different techniques: speckle tracking ultrasonography and multislice CT.

Affiliations:
Frankowska E.-Military Medical Institute (PL)
Trawiński Z.-IPPT PAN
Zegadło A.-other affiliation
Olszewski R.-other affiliation
Nowicki A.-IPPT PAN
Bogusławska R.-Military Medical Institute (PL)

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pdf
427853
2018-11-21
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Olszewski R., Krupienicz A.
Elektroda wewnątrzsercowa/cewnik do stymulacji serca i podawania leków
PL, Instytut Podstawowych Problemów Techniki PAN
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