Partner: D. Elbaum


Ostatnie publikacje
1.Baranowska-Korczyc A., Reszka A., Sobczak K., Sikora B., Dziawa P., Aleszkiewicz M., Kłopotowski Ł., Paszkowicz W., Dłużewski P., Kowalski B.J., Kowalewski T.A., Sawicki M., Elbaum D., Fronc K., Magnetic Fe doped ZnO nanofibers obtained by electrospinning, JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, ISSN: 0928-0707, DOI: 10.1007/s10971-011-2650-1, Vol.61, No.3, pp.494-500, 2012

Streszczenie:

Comprehensive studies of drug transport in nanofibres based mats have been performed to predict drug release kinetics. The paper presents our approach to analyze the impact of fibers arrangement, one of the parameters varied in our parallel experimental studies. Drug encapsulation in submicron fibers and subsequent controlled release of drugs is a tedious task due to the large number of process and material parameters involved. In the numerical study we constructed a 3D finite element geometry representing nanofibrous cubic element. COMSOL Multiphysics has been used to assess the impact of the various purposed arrangements of fibers within the mat. Drug release from nanofibers was modeled by adsorption -desorption and diffusion equation, where drug diffusion coefficient in the fluid between the fibers was altered depending on porosity of the material. Our study shows that for the same material porosity drug release from the matrix of regularly oriented fibers is slower than from randomly oriented, isotropic nanofibrous material. Also by decreasing distance between the fibers drug transport rate is reduced.

Słowa kluczowe:

Electrospinning, ZnO nanofibers, ZnFeO, Room temperature ferromagnetism, Magnetic oxides

Afiliacje autorów:

Baranowska-Korczyc A.-other affiliation
Reszka A.-other affiliation
Kowalewski T.A.-IPPT PAN
Sawicki M.-other affiliation
Elbaum D.-other affiliation
Fronc K.-other affiliation
Sobczak K.-other affiliation
Sikora B.-other affiliation
Dziawa P.-other affiliation
Aleszkiewicz M.-other affiliation
Kłopotowski Ł.-other affiliation
Paszkowicz W.-other affiliation
Dłużewski P.-other affiliation
Kowalski B.J.-other affiliation
35p.
2.Kowalczyk T., Nowicka A., Elbaum D., Kowalewski T.A., Electrospinning of bovine serum albumin. Optimization and the use for production of biosensors, BIOMACROMOLECULES, ISSN: 1525-7797, DOI: 10.1021/bm800421s, Vol.9, No.7, pp.2087-2090, 2008

Streszczenie:

Electrospinning of the globular protein, bovine serum albumin (BSA), was optimized to obtain proteinous fibers suitable asbiosensors. It was shown that the as-spun protein preserves its native form, whereas solubility of the cross-linked in the ambient conditions BSA nanofibers evidently decreases. Insoluble BSA fibers can be easily modified to be used as two-dimensional biosensors. Here, we show the micro pH sensor obtained from the BSA fiber stained with a fluorescein derivative (FITC).

Słowa kluczowe:

Electrospinning BSA, pH sensor

Afiliacje autorów:

Kowalczyk T.-IPPT PAN
Nowicka A.-IPPT PAN
Elbaum D.-other affiliation
Kowalewski T.A.-IPPT PAN