Partner: M. Rafienia

Isfahan University of Medical Sciences (IR)

Ostatnie publikacje
1.Enayati M.S., Behzad T., Sajkiewicz P., Rafienia M., Bagheri R., Ghasemi-Mobarakeh L., Kołbuk D., Pahlevanneshan Z., Bonakdar S.H., Development of electrospun poly (vinyl alcohol)-based bionanocomposite scaffolds for bone tissue engineering, Journal of Biomedical Materials Research Part A, ISSN: 1549-3296, DOI: 10.1002/jbm.a.36309, Vol.106, No.4, pp.1111-1120, 2018

Streszczenie:

The article is focused on the role of nanohydroxy apatite (nHAp) and cellulose nanofibers (CNFs) as fillers in the electrospun poly (vinyl alcohol) (ES-PVA) nanofibers for bone tissue engineering (TE). Fibrous scaffolds of PVA, PVA/nHAp (10 wt.%), and PVA/nHAp(10 wt.%)/CNF(3 wt.%) were successfully fabricated and characterized. Tensile test on electrospun PVA/nHAp10 and PVA/nHAp10/CNF3 revealed a three-fold and seven-fold increase in modulus compared with pure ES-PVA (45.45 ± 4.77). Although, nanofiller loading slightly reduced the porosity percentage, all scaffolds had porosity higher than 70%. In addition, contact angle test proved the great hydrophilicity of scaffolds. The presence of fillers reduced in vitro biodegradation rate in PBS while accelerates biomineralization in simulated body fluid (SBF). Furthermore, cell viability, cell attachment, and functional activity of osteoblast MG-63 cells were studied on scaffolds showing higher cellular activity for scaffolds with nanofillers. Generally, the obtained results confirm that the 3-componemnt fibrous scaffold of PVA/nHAp/CNF has promising potential in hard TE.

Słowa kluczowe:

electrospinning, PVA bionanocomposites, scaffolds, bone tissue engineering, cell culture

Afiliacje autorów:

Enayati M.S.-Isfahan University of Technology (IR)
Behzad T.-Isfahan University of Technology (IR)
Sajkiewicz P.-IPPT PAN
Rafienia M.-Isfahan University of Medical Sciences (IR)
Bagheri R.-Isfahan University of Technology (IR)
Ghasemi-Mobarakeh L.-Isfahan University of Technology (IR)
Kołbuk D.-IPPT PAN
Pahlevanneshan Z.-Payame Noor University (IR)
Bonakdar S.H.-Pasteur Institute of Iran (IR)
35p.

Prace konferencyjne
1.Enayati M.S., Behzad T., Sajkiewicz P., Rafienia M., Bagheri R., Ghasemi-Mobarakeh L., A novel electrospun three-component Bionanocomposite for bone tissue engineering, ICNS7, 7th International Conference on Nanostructures , 2018-02-27/03-01, Teheran (IR), pp.1-3, 2018

Streszczenie:

In the present study, a full bionanocomposite scaffold from poly (vinyl alcohol) (PVA), nanohydroxy apatite (nHAp) and cellulose nanofibers (CNF) was fabricated by electospinning and its potential application for bone tissue engineering was investigated. Morphology of the electrospun scaffolds was seen by field emission scanning electron microscope (FE-SEM). Both nHAp and CNF enhanced the tensile modulus of the scaffolds; however, both tensile strength as well as slongation at break showed reduced behaviour. Porosity measurement showed that scaffolds had porosity more than 70% which is appropriate for tissue engineering scaffolds. Contact angle test proved high hydrophilicty of electrospun mats while nanofiller incorporation promoted hydrophilicity. Biodegradability was investigated in phosphate buffer saline (PBS). In vitro biomineralization in simulated body fluid (SBF) and MTT cytotoxicity analysis showed that addition of nHAp and CNF increased bioactivity and cell viability of the scaffolds. The obtained results offered a 3-component promising scaffold for bone tissue engineering.

Słowa kluczowe:

Bionanocomposite, Scaffold, Electrospinning, Poly (vinyl alcohol) and Bone tissue engineering

Afiliacje autorów:

Enayati M.S.-IPPT PAN
Behzad T.-Isfahan University of Technology (IR)
Sajkiewicz P.-IPPT PAN
Rafienia M.-Isfahan University of Medical Sciences (IR)
Bagheri R.-Isfahan University of Technology (IR)
Ghasemi-Mobarakeh L.-Isfahan University of Technology (IR)