Partner: M.S. Enayati

Isfahan University of Technology (IR)

Ostatnie publikacje
1.Enayati M.S., Behzad T., Sajkiewicz P., Rafienia M., Bagheri R., Ghasemi-Mobarakeh L., Kołbuk D., Pahlevanneshan Z., Bonakdar S.H., Development of electrospun poly (vinyl alcohol)-based bionanocomposite scaffolds for bone tissue engineering, Journal of Biomedical Materials Research Part A, ISSN: 1549-3296, DOI: 10.1002/jbm.a.36309, pp.1-10, 2018

Streszczenie:

The article is focused on the role of nanohydroxy apatite (nHAp) and cellulose nanofibers (CNFs) as fillers in the electrospun poly (vinyl alcohol) (ES-PVA) nanofibers for bone tissue engineering (TE). Fibrous scaffolds of PVA, PVA/nHAp (10 wt.%), and PVA/nHAp(10 wt.%)/CNF(3 wt.%) were successfully fabricated and characterized. Tensile test on electrospun PVA/nHAp10 and PVA/nHAp10/CNF3 revealed a three-fold and seven-fold increase in modulus compared with pure ES-PVA (45.45 ± 4.77). Although, nanofiller loading slightly reduced the porosity percentage, all scaffolds had porosity higher than 70%. In addition, contact angle test proved the great hydrophilicity of scaffolds. The presence of fillers reduced in vitro biodegradation rate in PBS while accelerates biomineralization in simulated body fluid (SBF). Furthermore, cell viability, cell attachment, and functional activity of osteoblast MG-63 cells were studied on scaffolds showing higher cellular activity for scaffolds with nanofillers. Generally, the obtained results confirm that the 3-componemnt fibrous scaffold of PVA/nHAp/CNF has promising potential in hard TE.

Słowa kluczowe:

electrospinning, PVA bionanocomposites, scaffolds, bone tissue engineering, cell culture

Afiliacje autorów:

Enayati M.S.-Isfahan University of Technology (IR)
Behzad T.-Isfahan University of Technology (IR)
Sajkiewicz P.-IPPT PAN
Rafienia M.-Isfahan University of Medical Sciences (IR)
Bagheri R.-Isfahan University of Technology (IR)
Ghasemi-Mobarakeh L.-Isfahan University of Technology (IR)
Kołbuk D.-IPPT PAN
Pahlevanneshan Z.-Payame Noor University (IR)
Bonakdar S.H.-Pasteur Institute of Iran (IR)
35p.
2.Enayati M.S., Behzad T., Sajkiewicz P.Ł., Bagheri R., Ghasemi-Mobarakeh L., Pierini F., Theoretical and experimental study of the stiffness of electrospun composites of poly(vinyl alcohol), cellulose nanofibers, and nanohydroxy apatite, CELLULOSE, ISSN: 0969-0239, DOI: 10.1007/s10570-017-1601-6, pp.1-11, 2017

Streszczenie:

The present study aims to theoretically model and verify the mechanical behavior of electrospun fibers of poly(vinyl alcohol) (PVA) reinforced by nanohydroxy apatite (nHAp) and cellulose nanofibers (CNF), the three composites designated as PVA/nHAp, PVA/CNF, and PVA/nHAp/CNF. Tensile tests and AFM nanoindentation studies were used to measure tensile modulus of electrospun scaffolds and single fibers respectively. Halpin–Tsai and Ouali models were applied to predict the stiffness of electrospun mats. Theoretical analysis according to the Halpin–Tsai model showed that CNF have no preferred orientation in the electrospun fibers, particularly at higher filler content. Additionally, this model provided a better prediction than Ouali model, especially at lower filler content. Theoretical models based on the geometry of an unit cell in open-cell structure such as honeycomb, tetrakaidecahedron and cube models simulate electrospun scaffolds. Among the structural models for analysis of porous scaffolds, the honeycomb model showed the best prediction, tetrakaidecahedron model—a moderate one, and cube model was the worst. In general, it was proved by both experiment and theory that the porous structure of electrospun mat caused significant modulus reduction of nanocomposites.

Słowa kluczowe:

Nanocomposites, Cellulose nanofibers, Electrospinning, Modulus

Afiliacje autorów:

Enayati M.S.-IPPT PAN
Behzad T.-Isfahan University of Technology (IR)
Sajkiewicz P.Ł.-IPPT PAN
Bagheri R.-Isfahan University of Technology (IR)
Ghasemi-Mobarakeh L.-Isfahan University of Technology (IR)
Pierini F.-IPPT PAN
45p.
3.Enayati M.S., Behzad T., Sajkiewicz P., Bagheri R., Ghasemi‑Mobarakeh L., Łojkowski W., Pahlevanneshan Z., Ahmadi M., Crystallinity study of electrospun poly (vinyl alcohol) nanofibers: effect of electrospinning, filler incorporation, and heat treatment, IRANIAN POLYMER JOURNAL, ISSN: 1026-1265, DOI: 10.1007/s13726-016-0455-3, Vol.25, No.7, pp.647-659, 2016

Streszczenie:

This study aims to explore crystallinity variations of polyvinyl alcohol (PVA) as a result of electrospinning, filler addition, and heat treatment. Pure PVA and PVA nanocomposite fibers containing only nanohydroxy apatite (nHAp) and together with cellulose nanofibers (CNF) were electrospun. Electrospun nanofibers were heat treated at 180°C for 8 h. The morphology of electrospun fibers was evaluated by scanning electron microscopy (SEM) while Fourier transform infrared spectroscopy, differential scanning calorimetry, and wide angle X-ray scattering were used to analyze nanofibers crystallinity. Un-treated electrospun nanofibers were shrank and lost their porous structure in water, while heat treatment of nanofibers caused stabilization of fibrous mats in boiling water. It was concluded that the crystallinity of electrospun PVA were considerably reduced compared to PVA powder due to formation of metastable—small and/or defective crystals. Adding small content (1 wt%) of nHAp led to increase in electrospun nanofibers crystallinity. However, incorporation of higher content of nHAp and CNF caused reduction of crystallinity most probably due to possible interactions among components which interrupt the orientation of macromolecules. All analyzing methods proved the crystallinity enhancement of nanofibers upon heat treatment which can be attributed mostly to water evaporation from electrospun fibers structure.

Słowa kluczowe:

Polyvinyl alcohol, Crystallinity, Electrospinning, Nanofiber, Nanofiller, Heat treatment

Afiliacje autorów:

Enayati M.S.-Isfahan University of Technology (IR)
Behzad T.-Isfahan University of Technology (IR)
Sajkiewicz P.-IPPT PAN
Bagheri R.-Isfahan University of Technology (IR)
Ghasemi‑Mobarakeh L.-Isfahan University of Technology (IR)
Łojkowski W.-other affiliation
Pahlevanneshan Z.-Payame Noor University (IR)
Ahmadi M.-Isfahan University of Technology (IR)
25p.
4.Enayati M.S., Behzad T., Sajkiewicz P., Bagheri R., Ghasemi‑Mobarakeh L., Kuśnieruk S., Rogowska-Tylman J., Pahlevanneshan Z., Choińska E., Święszkowski W., Fabrication and characterization of electrospun bionanocomposites of poly (vinyl alcohol)/ nanohydroxyapatite/cellulose nanofibers, International Journal of Polymeric Materials and Polymeric Biomaterials, ISSN: 0091-4037, DOI: 10.1080/00914037.2016.1157798, Vol.65, No.13, pp.660-674, 2016

Streszczenie:

The aim of the present study was preparation, optimization, and systematic characterization of electrospun bionanocomposite fibers based on polyvinyl alcohol (PVA) as matrix and nanohydroxy apatite (nHAp) and cellulose nanofibers (CNF) as nanoreinforcements. The presence of nHAp and nHAp-CNF affected the morphology of electrospun mats and reduced fiber diameter, particularly at a higher content of nanofillers. The obtained results of FTIR, DSC, and WAXS proved the crystallinity reduction of electrospun nancomposites. Both nHAp and nHAp-CNF addition led to a significant increase of Young modulus with the highest stiffness for nanocomposite fibers at 10 wt% of nHAp and 3 wt% of CNF.

Słowa kluczowe:

Bionanocomposite, cellulose nanofibers, electrospinning, nanohydroxy apatite

Afiliacje autorów:

Enayati M.S.-Isfahan University of Technology (IR)
Behzad T.-Isfahan University of Technology (IR)
Sajkiewicz P.-IPPT PAN
Bagheri R.-Isfahan University of Technology (IR)
Ghasemi‑Mobarakeh L.-Isfahan University of Technology (IR)
Kuśnieruk S.-other affiliation
Rogowska-Tylman J.-other affiliation
Pahlevanneshan Z.-Payame Noor University (IR)
Choińska E.-Warsaw University of Technology (PL)
Święszkowski W.-other affiliation
20p.