Partner: Rajiv Chaturvedi

University of Notre Dame (US)

Ostatnie publikacje
1.Chaturvedi R., Huang C., Kaźmierczak B., Schneider T., Izaguirre J., Glimm T., Hentschel H.G.E., Glazier J., Newman S., Alber M., On multiscale approaches to three-dimensional modelling of morphogenesis, JOURNAL OF THE ROYAL SOCIETY INTERFACE, ISSN: 1742-5689, DOI: 10.1098/rsif.2005.0033, Vol.2, pp.237-253, 2005


In this paper we present the foundation of a unified, object-oriented, three-dimensional biomodelling environment, which allows us to integrate multiple submodels at scales from subcellular to those of tissues and organs. Our current implementation combines a modified discrete model from statistical mechanics, the Cellular Potts Model, with a continuum reaction–diffusion model and a state automaton with well-defined conditions for cell differentiation transitions to model genetic regulation. This environment allows us to rapidly and compactly create computational models of a class of complex-developmental phenomena. To illustrate model development, we simulate a simplified version of the formation of the skeletal pattern in a growing embryonic vertebrate limb.

Afiliacje autorów:

Chaturvedi R.-University of Notre Dame (US)
Huang C.-University of Notre Dame (US)
Kaźmierczak B.-IPPT PAN
Schneider T.-University College London (GB)
Izaguirre J.-University of Notre Dame (US)
Glimm T.-Western Washington University (US)
Hentschel H.G.E.-Emory University (US)
Glazier J.-Indiana University (US)
Newman S.-New York Medical College (US)
Alber M.-University of Notre Dame (US)