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Polish Academy of Sciences

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A.T. Poortinga

Eindhoven University of Technology (NL)

Recent publications
1.  Kotopoulis S., Johansen K., Gilja O.H., Poortinga A.T., Postema M., Acoustically Active Antibubbles, ACTA PHYSICA POLONICA A, ISSN: 0587-4246, DOI: 10.12693/APhysPolA.127.99, Vol.127, No.1, pp.99-102, 2015

Abstract:
In this study, we analyse the behaviour of antibubbles when subjected to an ultrasonic pulse. Speci cally, we derive oscillating behaviour of acoustic antibubbles with a negligible outer shell, resulting in a Rayleigh Plesset equation of antibubble dynamics. Furthermore, we compare theoretical behaviour of antibubbles to behaviour of regular gas bubbles. We conclude that antibubbles and regular bubbles respond to an acoustic wave in a very similar manner if the antibubble's liquid core radius is less than half the antibubble radius. For larger cores, antibubbles demonstrate highly harmonic behaviour, which would make them suitable vehicles in ultrasonic imaging and ultrasound-guided drug delivery.

Affiliations:
Kotopoulis S. - Haukeland University Hospital (NO)
Johansen K. - University of Bergen (NO)
Gilja O.H. - Haukeland University Hospital (NO)
Poortinga A.T. - Eindhoven University of Technology (NL)
Postema M. - other affiliation

Conference papers
1.  Johansen K., Kotopoulis S., Poortinga A.T., Postema M., Nonlinear echoes from encapsulated antibubbles, Physics Procedia, ISSN: 1875-3892, DOI: 10.1016/j.phpro.2015.08.230, Vol.70, pp.1079-1082, 2015

Abstract:
An antibubble consists of a liquid droplet, surrounded by a gas, often with an encapsulating shell. Antibubbles of microscopic sizes suspended in fluids are acoustically active in the ultrasonic range. Antibubbles have applications in food processing and guided drug delivery. We study the sound generated from antibubbles, with droplet core sizes in the range of 0–90% of the equilibrium antibubble inner radius. The antibubble resonance frequency, the phase difference of the echo with respect to the incident acoustic pulse, and the presence of higher harmonics are strongly dependent of the core droplet size. Antibubbles oscillate highly nonlinearly around resonance size. This may allow for using antibubbles in clinical diagnostic imaging and targeted drug delivery.

Keywords:
Antibubble, Nonlinear, Echo, Rayleigh-Plesset, Targeted drug delivery

Affiliations:
Johansen K. - University of Bergen (NO)
Kotopoulis S. - Haukeland University Hospital (NO)
Poortinga A.T. - Eindhoven University of Technology (NL)
Postema M. - other affiliation

Conference abstracts
1.  Johansen K., Kotopoulis S., Poortinga A.T., Postema M., Harmonic antibubbles, 10th EAA International Symposium on Hydroacoustics, 2016-05-17/05-16, Jastrzębia Góra (PL), DOI: 10.1515/aoa-2016-0038, Vol.41, No.2, Abstract, pp.364, 2016

Abstract:
We study the sonication of stable particles that encapsulate a liquid core, so-called antibubbles. Acoustically active antibubbles can potentially be used for ultrasound-guided drug delivery. In this presentation, we derive the oscillating behaviour of acoustic antibubbles with a negligible outer shell, resulting in a Rayleigh-Plesset equation of antibubble dynamics. Furthermore, we compare the theoretical behaviour of antibubbles to that of regular gas bubbles. We conclude that antibubbles and regular bubbles are acoustically active in a very similar way, if the liquid core is less than half the antibubble radius. For larger cores, antibubbles demonstrate highly harmonic behaviour, which would make them suitable vehicles in ultrasonic imaging and ultrasound-guided drug delivery.

Keywords:
Harmonics, Antibubbles

Affiliations:
Johansen K. - University of Bergen (NO)
Kotopoulis S. - Haukeland University Hospital (NO)
Poortinga A.T. - Eindhoven University of Technology (NL)
Postema M. - other affiliation
2.  Johansen K., Kotopoulis S., Poortinga A.T., Postema M., Antibubbles, International Conference for Young Researchers. Wave Electronics and its Applications in the Information and Telecommunication Systems, St. Petersburg (RU), Vol.XVIII, pp.15, 2015
3.  Kotopoulis S., Johansen K., Poortinga A., Gilja O.H., Postema M., Acoustically active antibubbles for ultrasound imaging and targeted drug delivery, The 2014 Joint National PhD Conference in Medical Imaging and MedViz Conference, 2014/, Bergen (NO), pp.115, 2014

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