Institute of Fundamental Technological Research
Polish Academy of Sciences

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J. Grimbergen

ProFibrix BV (NL)

Recent publications
1.  Piechocka I.K., Kurniawan N.A., Grimbergen J., Koopman J., Koenderink G.H., Recombinant fibrinogen reveals the differential roles of α- and γ-chain cross-linking and molecular heterogeneity in fibrin clot strain-stiffening, Journal of Thrombosis and Haemostasis, ISSN: 1538-7933, DOI: 10.1111/jth.13650, Vol.15, No.5, pp.938-949, 2017

Abstract:
Essentials Fibrinogen circulates in human plasma as a complex mixture of heterogeneous molecular variants. We measured strain-stiffening of recombinantly produced fibrinogen upon clotting. Factor XIII and molecular heterogeneity alter clot elasticity at the protofibril and fiber level. This highlights the hitherto unknown role of molecular composition in fibrin clot mechanics.

Keywords:
blood coagulation, elasticity, fibrin, polymers, rheology, turbidimetry

Affiliations:
Piechocka I.K. - IPPT PAN
Kurniawan N.A. - Eindhoven University of Technology (NL)
Grimbergen J. - ProFibrix BV (NL)
Koopman J. - ProFibrix BV (NL)
Koenderink G.H. - FOM Institute AMOLF (NL)

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