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Piotrzkowska-Wróblewska H., Karwat P., Dobrych-Sobczak K.♦, Żyłka A.♦, Litniewski J., Calcifications and Margins as Biomarkers in Differentiating Thyroid Cancer Subtypes,
IEEE IUS 2025, International Ultrasonics Symposium, 2025-09-15/09-18, Utreht (NL), pp.1-4, 2025 Abstract:
Accurate preoperative differentiation of thyroid cancer subtypes is essential for optimizing treatment strategies, particularly in the context of rising incidence rates and increasing use of active surveillance. This study investigates quantitative ultrasound biomarkers based on calcification patterns and tumor margins for distinguishing papillary, follicular, and medullary thyroid carcinomas. The analysis included 110 patients with histopathologically confirmed diagnoses. Tumor boundaries were refined using an energy minimization algorithm, and calcifications were classified by size and location. Margin characteristics were quantified using contrast variance. Each feature demonstrated an AUC > 0.75, with combined biomarkers achieving an AUC of 0.92 for follicular carcinoma detection (sensitivity: 0.87, specificity: 0.76). The results highlight the potential of quantitative assessment of calcifications and margins to enhance ultrasound-based classification of thyroid cancer subtypes. Keywords:
thyroid cancer, ultrasound, calcifications, tumor margins, quantitative imaging, computer-aided diagnosis Affiliations:
| Piotrzkowska-Wróblewska H. | - | IPPT PAN | | Karwat P. | - | IPPT PAN | | Dobrych-Sobczak K. | - | other affiliation | | Żyłka A. | - | other affiliation | | Litniewski J. | - | IPPT PAN |
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