Institute of Fundamental Technological Research
Polish Academy of Sciences

Partners

Mohsin Kazi


Recent publications
1.  Ijaz U., Sohail M., Minhas Muhammad U., Khan S., Hussain Z., Kazi M., Shah S. A., Mahmood A., Maniruzzaman M., Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing, Polymers, ISSN: 2073-4360, DOI: 10.3390/polym14030376, Vol.14, No.3, pp.376-1-20, 2022

Abstract:
The in situ injectable hydrogel system offers a widespread range of biomedical applications in prompt chronic wound treatment and management, as it provides self-healing, maintains a moist wound microenvironment, and offers good antibacterial properties. This study aimed to develop and evaluate biopolymer-based thermoreversible injectable hydrogels for effective wound-healing applications and the controlled drug delivery of meropenem. The injectable hydrogel was developed using the solvent casting method and evaluated for structural changes using proton nuclear magnetic resonance, Fourier transforms infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The results indicated the self-assembly of hyaluronic acid and kappa-carrageenan and the thermal stability of the fabricated injectable hydrogel with tunable gelation properties. The viscosity assessment indicated the in-situ gelling ability and injectability of the hydrogels at various temperatures. The fabricated hydrogel was loaded with meropenem, and the drug release from the hydrogel in phosphate buffer saline (PBS) with a pH of 7.4 was 96.12%, and the simulated wound fluid with a pH of 6.8 was observed to be at 94.73% at 24 h, which corresponds to the sustained delivery of meropenem. Antibacterial studies on P. aeruginosa, S. aureus, and E. coli with meropenem-laden hydrogel showed higher zones of inhibition. The in vivo studies in Sprague Dawley (SD) rats presented accelerated healing with the drug-loaded injectable hydrogel, while 90% wound closure with the unloaded injectable hydrogel, 70% in the positive control group (SC drug), and 60% in the negative control group was observed (normal saline) after fourteen days. In vivo wound closure analysis confirmed that the developed polymeric hydrogel has synergistic wound-healing potential.

Keywords:
bioactive polymers,thermosensitive hydrogel,biomaterials,wound repair and regeneration

Affiliations:
Ijaz U. - other affiliation
Sohail M. - other affiliation
Minhas Muhammad U. - other affiliation
Khan S. - other affiliation
Hussain Z. - other affiliation
Kazi M. - other affiliation
Shah S. A. - IPPT PAN
Mahmood A. - other affiliation
Maniruzzaman M. - other affiliation

Category A Plus

IPPT PAN

logo ippt            Pawińskiego 5B, 02-106 Warsaw
  +48 22 826 12 81 (central)
  +48 22 826 98 15
 

Find Us

mapka
© Institute of Fundamental Technological Research Polish Academy of Sciences 2024