Institute of Fundamental Technological Research
Polish Academy of Sciences


M. Potters

Vrije Universiteit (NL)

Recent publications
1.  Piechocka I.K., Bacabac R.G., Potters M., MacKintosh F.C., Koenderink G.H., Structural Hierarchy Governs Fibrin Gel Mechanics, BIOPHYSICAL JOURNAL, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2010.01.040, Vol.98, No.10, pp.2281-2289, 2010

Fibrin gels are responsible for the mechanical strength of blood clots, which are among the most resilient protein materials in nature. Here we investigate the physical origin of this mechanical behavior by performing rheology measurements on reconstituted fibrin gels. We find that increasing levels of shear strain induce a succession of distinct elastic responses that reflect stretching processes on different length scales. We present a theoretical model that explains these observations in terms of the unique hierarchical architecture of the fibers. The fibers are bundles of semiflexible protofibrils that are loosely connected by flexible linker chains. This architecture makes the fibers 100-fold more flexible to bending than anticipated based on their large diameter. Moreover, in contrast with other biopolymers, fibrin fibers intrinsically stiffen when stretched. The resulting hierarchy of elastic regimes explains the incredible resilience of fibrin clots against large deformations.

Piechocka I.K. - other affiliation
Bacabac R.G. - FOM Institute AMOLF (NL)
Potters M. - Vrije Universiteit (NL)
MacKintosh F.C. - Vrije Universiteit (NL)
Koenderink G.H. - FOM Institute AMOLF (NL)

Category A Plus


logo ippt            Pawińskiego 5B, 02-106 Warsaw
  +48 22 826 12 81 (central)
  +48 22 826 98 15

Find Us

© Institute of Fundamental Technological Research Polish Academy of Sciences 2021