Institute of Fundamental Technological Research
Polish Academy of Sciences

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S.K. Misra


Recent publications
1.  Bretcanu O., Misra S.K., Yunos D.M., Boccaccini A.R., Roy I., Kowalczyk T., Błoński S., Kowalewski T.A., Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering, MATERIALS CHEMISTRY AND PHYSICS, ISSN: 0254-0584, DOI: 10.1016/j.matchemphys.2009.08.011, Vol.118, pp.420-426, 2009

Abstract:
Biodegradable polymeric nanofibrous coatings were obtained by electrospinning different polymers onto sintered 45S5 Bioglass®-based glass-ceramic pellets. The investigated polymers were poly(3-hydroxybutyrate) (P3HB), poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV) and a composite of poly(caprolactone) (PCL) and poly(ethylene oxide) (PEO) (PCL–PEO). The fibrous coatings morphology was evaluated by optical microscopy and scanning electron microscopy. The electrospinning process parameters were optimised to obtain reproducible coatings formed by a thin web of polymer nanofibres. In-vitro studies in simulated body fluid (SBF) were performed to investigate the bioactivity and mineralisation of the substrates by inducing the formation of hydroxyapatite (HA) on the nanofiber-coated pellets. HA crystals were detected on all samples after 7 days of immersion in SBF, however the morphology of the HA layer depended on the characteristic fibre diameter, which in turn was a function of the specific polymer-solvent system used. The bioactive and resorbable nanofibrous coatings can be used to tailor the surface topography of bioactive glass-ceramics for applications in tissue engineering scaffolds.

Keywords:
Electrospinning, Nanofibers, Bioglass®, Polyhydroxyalkanoates, Tissue engineering

Affiliations:
Bretcanu O. - other affiliation
Misra S.K. - other affiliation
Yunos D.M. - other affiliation
Boccaccini A.R. - Friedrich-Alexander University of Erlangen-Nürnberg (DE)
Roy I. - other affiliation
Kowalczyk T. - IPPT PAN
Błoński S. - IPPT PAN
Kowalewski T.A. - IPPT PAN

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