Institute of Fundamental Technological Research
Polish Academy of Sciences

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A. Mostafavi


Recent publications
1.  Nasajpour A., Mostafavi A., Chlanda A., Rinoldi C., Sharifi S., Ji M.S., Ye M., Jonas S.J., Święszkowski W., Weiss P.S., Khademhosseini A., Tamayol A., Cholesteryl ester liquid crystal nanofibers for tissue engineering applications, ACS Materials Letters, ISSN: 2639-4979, DOI: 10.1021/acsmaterialslett.0c00224, Vol.2, No.9, pp.1067-1073, 2020

Abstract:
Liquid-crystal-based biomaterials provide promising platforms for the development of dynamic and responsive interfaces for tissue engineering. Cholesteryl ester liquid crystals (CLCs) are particularly well suited for these applications, due to their roles in cellular homeostasis and their intrinsic ability to organize into supramolecular helicoidal structures on the mesoscale. Here, we developed a nonwoven CLC electrospun scaffold by dispersing three cholesteryl ester-based mesogens within polycaprolactone (PCL). We tuned the ratio of our mesogens so that the CLC would be in the mesophase at the cell culture incubator temperature of 37°C. In these scaffolds, the PCL polymer provided an elastic bulk matrix while the homogeneously dispersed CLC established a viscoelastic fluidlike interface. Atomic force microscopy revealed that the 50% (w/v) cholesteryl ester liquid crystal scaffold (CLC-S) exhibited a mesophase with topographic striations typical of liquid crystals. Additionally, the CLC-S favorable wettability and ultrasoft fiber mechanics enhanced cellular attachment and proliferation. Increasing the CLC concentration within the composites enhanced myoblast adhesion strength promoted myofibril formationin vitrowith mouse myoblast cell lines.

Affiliations:
Nasajpour A. - Massachusetts Institute of Technology (US)
Mostafavi A. - other affiliation
Chlanda A. - Warsaw University of Technology (PL)
Rinoldi C. - other affiliation
Sharifi S. - other affiliation
Ji M.S. - other affiliation
Ye M. - other affiliation
Jonas S.J. - other affiliation
Święszkowski W. - other affiliation
Weiss P.S. - other affiliation
Khademhosseini A. - Massachusetts Institute of Technology (US)
Tamayol A. - Massachusetts Institute of Technology (US)

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