Institute of Fundamental Technological Research
Polish Academy of Sciences


Maciej Sierakowski

Recent publications
1.  Cegielska O., Sierakowski M., Sajkiewicz P., Lorenz K., Kogermann K., Mucoadhesive brinzolamide-loaded nanofibers for alternative glaucoma treatment, European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2022.09.008, Vol.180, pp.48-62, 2022

Despite the advances in the field of pharmaceutical materials and technology, topical administration remains a method of choice for the treatment of eye diseases such as glaucoma, with eye drops being a leading dosage form. Their main disadvantage is a very short drug residence time and thus poor drug bioavailability, leading to the necessity of continuous repeated dosing. Mucoadhesive electrospun nanofibers are promising candidates for overcoming these challenges, while still benefiting from topical ocular administration. As an alternative for eye drops, a nanofibrous drug delivery system (DDS) for the delivery of brinzolamide (BRZ), based on β-cyclodextrin (β-CD), hydroxypropyl cellulose (HPC) and polycaprolactone (PCL), was designed. The results showed β-CD/BRZ guest–host interactions, successful drug incorporation into the nanofibers, and the possibility of more accurate dosing in comparison with the control eye drops. Drug permeation through sheep corneas was almost linear in time, achieving therapeutic concentrations in the receptor medium, and mucoadhesion to sheep eye mucosa was relatively high in case of formulations with high HPC content. All formulations were biocompatible, their mechanical properties were sufficient to handle them without caution and UV irradiation was suitable to reduce bioburden of the fibers matrix, yet no antibacterial properties of BRZ were observed.

Drug delivery system, Nanofibers, Electrospinning, Cyclodextrins, Glaucoma, Mucoadhesion, Topical administration

Cegielska O. - IPPT PAN
Sierakowski M. - other affiliation
Sajkiewicz P. - IPPT PAN
Lorenz K. - other affiliation
Kogermann K. - other affiliation

Conference abstracts
1.  Cegielska O., Sajkiewicz P., Sierakowski M., Mucoadhesion and biological evaluation of brinzolamide-loaded electrospun nanofibers – in vitro and ex vivo assessment, FEMS EUROMAT 2023, 17th European Congress and Exhibition on Advanced Materials and Processes, 2023-09-03/09-07, Frankfurt n/Menem (DE), pp.1, 2023
2.  Cegielska O., Sajkiewicz P., Sierakowski M., Electrospun brinzolamide carrier – potential antiglaucoma drug delivery platform, ESB 2021, 31st Annual Conference of the European Society for Biomaterials, 2021-09-05/09-09, Porto (PT), pp.1338-1339, 2021

Category A Plus


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