Staff

Abstract:
Objective: Neoadjuvant chemotherapy (NAC) in breast cancer requires non-invasive methods of monitoring its effects after each dose of drug therapy. The aim is to isolate responding and non-responding tumors prior to surgery in order to increase patient safety and select the optimal medical follow-up. Methods: A new method of monitoring NAC therapy has been proposed. The method is based on image quality indexes (IQI) calculated from ultrasound data obtained from breast tumors and surrounding tissue. Four different tissue regions from the preliminary set of 38 tumors and three data pre-processing techniques are considered. Postoperative histopathology results were used as a benchmark in evaluating the effectiveness of the IQI classification. Results: Out of ten parameters considered, the best results were obtained for the Gray Relational Coefficient. Responding and non-responding tumors were predicted after the first dose of NAC with an area under the receiver operating characteristics curve of 0.88 and 0.75, respectively. When considering subsequent doses of NAC, other IQI parameters also proved usefulness in evaluating NAC therapy. Conclusions: The image quality parameters derived from the ultrasound data are well suited for assessing the effects of NAC therapy, in particular on breast tumors.

Keywords:
Quantitative ultrasound; Image quality; Neoadjuvant chemotherapy; Breast cancer; Treatment response

Abstract:
In an interesting article previously published in Data in Brief [Dataset of breast ultrasound images" by W. Al-Dhabyani, M. Gomaa, H. Khaled & A. Fahmy, Data in Brief, 2020, 28, 104863], the authors presented a dataset of breast ultrasound images containing lesions. As of April 22, 2023, this study has garnered significant attention from researchers, as evident by its 298 citations in Scopus data. This is unsurprising considering that the study presents one of the few publicly available datasets on breast ultrasound images, as well as binary masks highlighting the lesions. When implementing various aspects of explainable AI, we verify the correctness of the input data at every stage, especially when using various data sources. In an attempt to use this dataset for research, we did some exploration and identified some inconsistencies that could have a significant impact on the results of the studies utilizing them. As the role of tumor detection is indisputable we feel obliged to point attention to some aspects that need to be kept in mind while using this database in order to receive reliable and good quality results.

Abstract:
Understanding the relationship between acoustic properties of breast lesions and resulting ultrasound images may contribute to an earlier and more accurate diagnosis of the most common cancer in women. In addition to in vitro studies, in silico tumor models can provide a lot of crucial information due to the possibility of precise determination of the influence of changes in tissue structure on the resulting ultrasound echoes. The purpose was to develop the numerical phantom of the breast with the tumor for a reliable simulation of ultrasound images. In modeling the tissue structures of the breast, the VICTRE phantom, developed by the FDA for the simulation of X-ray mammography, was used. The numerical ultrasound model of breast cancer allows the simulation of ultrasound signals and images. It could be used to interpret, validate and develop new ultrasound methods for cancer diagnosis

Keywords:
breast tumor, numerical phantom, ultrasound imaging

Abstract:
Standard classification methods based on hand-crafted morphological and texture features have achieved good performance in breast mass differentiation in ultrasound (US).
In comparison to deep neural networks, commonly perceived as ‘black-box’ models, classical techniques are based on features that have well-understood medical and physical interpretation. However, classifiers based on morphological features commonly
underperform in the presence of the shadowing artifact and ill-defined mass borders, while texture based classifiers may fail when the US image is too noisy. Therefore, in practice it would be beneficial to select the classification method based on the appearance of the particular US image. In this work, we develop a deep meta-network that can automatically process input breast mass US images and recommend whether to apply the shape or
texture based classifier for the breast mass differentiation. Our preliminary results demonstrate that meta-learning techniques can be used to improve the performance of the standard classifiers based on handcrafted features. With the proposed meta-learning based approach, we achieved the area under the receiver operating characteristic curve of 0.95 and accuracy of 0.91.

Keywords:
breast mass classification, deep learning, meta-learning, morphological features, texture features