Institute of Fundamental Technological Research
Polish Academy of Sciences

Partners

Kan Yue

Massachusetts Institute of Technology (US)

Recent publications
1.  Saghazadeh S., Rinoldi C., Schot M., Kashaf S.S., Sharifi F., Jalilian E., Nuutila K., Giatsidis G., Mostafalu P., Derakhshandeh H., Yue K., Święszkowski W., Memic A., Tamayol A., Khademhosseini A., Drug delivery systems and materials for wound healing applications, Advanced Drug Delivery Reviews, ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.04.008, Vol.127, pp.138-166, 2018

Abstract:
Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted.

Keywords:
Wound healing, Drug delivery, Transdermal delivery, Microtechnologies, Nanotechnologies

Affiliations:
Saghazadeh S. - Massachusetts Institute of Technology (US)
Rinoldi C. - other affiliation
Schot M. - Massachusetts Institute of Technology (US)
Kashaf S.S. - Massachusetts Institute of Technology (US)
Sharifi F. - Massachusetts Institute of Technology (US)
Jalilian E. - Massachusetts Institute of Technology (US)
Nuutila K. - Brigham and Women's Hospital (US)
Giatsidis G. - Brigham and Women's Hospital (US)
Mostafalu P. - Massachusetts Institute of Technology (US)
Derakhshandeh H. - University of Nebraska (US)
Yue K. - Massachusetts Institute of Technology (US)
Święszkowski W. - other affiliation
Memic A. - King Abdulaziz University (SA)
Tamayol A. - Massachusetts Institute of Technology (US)
Khademhosseini A. - Massachusetts Institute of Technology (US)

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