Institute of Fundamental Technological Research
Polish Academy of Sciences

Staff

Anna Zakrzewska, MSc

Department of Biosystems and Soft Matter (ZBiMM)
PhD student
telephone: (+48) 22 826 12 81 ext.: 422
room: 227
e-mail:

Recent publications
1.  Ziai Y., Petronella F., Rinoldi C., Nakielski P., Zakrzewska A., Kowalewski T.A., Augustyniak W., Li X., Calogero A., Sabała I., Ding B., De Sio L., Pierini F., Chameleon-inspired multifunctional plasmonic nanoplatforms for biosensing applications, NPG Asia Materials, ISSN: 1884-4049, DOI: 10.1038/s41427-022-00365-9, Vol.14, pp.18-1-17, 2022

Abstract:
One of the most fascinating areas in the field of smart biopolymers is biomolecule sensing. Accordingly, multifunctional biomimetic, biocompatible, and stimuli-responsive materials based on hydrogels have attracted much interest. Within this framework, the design of nanostructured materials that do not require any external energy source is beneficial for developing a platform for sensing glucose in body fluids. In this article, we report the realization and application of an innovative platform consisting of two outer layers of a nanocomposite plasmonic hydrogel plus one inner layer of electrospun mat fabricated by electrospinning, where the outer layers exploit photoinitiated free radical polymerization, obtaining a compact and stable device. Inspired by the exceptional features of chameleon skin, plasmonic silver nanocubes are embedded into a poly(N-isopropylacrylamide)-based hydrogel network to obtain enhanced thermoresponsive and antibacterial properties. The introduction of an electrospun mat creates a compatible environment for the homogeneous hydrogel coating while imparting excellent mechanical and structural properties to the final system. Chemical, morphological, and optical characterizations were performed to investigate the structure of the layers and the multifunctional platform. The synergetic effect of the nanostructured system’s photothermal responsivity and antibacterial properties was evaluated. The sensing features associated with the optical properties of silver nanocubes revealed that the proposed multifunctional system is a promising candidate for glucose-sensing applications.

Affiliations:
Ziai Y. - IPPT PAN
Petronella F. - other affiliation
Rinoldi C. - IPPT PAN
Nakielski P. - IPPT PAN
Zakrzewska A. - IPPT PAN
Kowalewski T.A. - IPPT PAN
Augustyniak W. - Mossakowski Medical Research Centre, Polish Academy of Sciences (PL)
Li X. - Donghua University (CN)
Calogero A. - Sapienza University of Rome (IT)
Sabała I. - Mossakowski Medical Research Centre, Polish Academy of Sciences (PL)
Ding B. - Donghua University (CN)
De Sio L. - Sapienza University of Rome (IT)
Pierini F. - IPPT PAN

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