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Abstract:
Brachial aortic Pulse Wave Velocity (baPWV) and bone mineral density (BMD) are important indicators of cardiovascular health and bone strength, respectively. However, the gender-specific association between baPWV and BMD remains unclear. The aim of our study is to evaluate the relationship between baPWV and
BMD in men and women populations Methods: A comprehensive search was conducted in electronic databases for relevant studies published between the 1th and 30rd of April 2023. Studies reporting the correlation between baPWV and BMD in both males and
females were considered. A random-effects model was used to calculate pooled correlation coefficients (r). Results: Relevant data for both genders were found in six articles. In all publications included in the meta-analysis, the total number of studied individuals was 3800, with 2054 women and 1746 men. Pooled correlation coefficient was -0,24 (95% CI: -0.34; -0.15) in women population, and -0.12 (95%CI: -0.16, -0.06) in
men. Conclusions: Based on the published data, we found that baPWV is negatively correlated with bone density in women. However, in men we do not find such a
relationship. These findings suggest the importance of considering gender-specific factors when assessing the cardiovascular and bone health relationship.

Keywords:
Bone mineral density, osteoporosis, brachial aortic Pulse Wave Velocity, arterial stiffness, gender differences