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Polish Academy of Sciences

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Jianyong Yu

Donghua University (CN)

Recent publications
1.  Wang M., Du J., Li M.S., Pierini F., Li X., Yu J., Ding B., In situ forming double-crosslinked hydrogels with highly dispersed short fibers for the treatment of irregular wounds, Biomaterials Science, ISSN: 2047-4849, DOI: 10.1039/D2BM01891H, Vol.11, No.7, pp.2383-2394, 2023

Abstract:
In situ forming injectable hydrogels hold great potential for the treatment of irregular wounds. However, their practical applications were hindered by long gelation time, poor mechanical performance, and a lack of a natural extracellular matrix structure. Herein, amino-modified electrospun poly(lactic-co-glycolic acid) (APLGA) short fibers with uniform distribution were introduced into gelatin methacrylate/oxidized dextran (GM/ODex) hydrogels. In comparison with the fiber aggregation structure in the PLGA fiber-incorporated hydrogels, the hydrogels with APLGA fibers possessed a uniform porous structure. The highly dispersed APLGA short fibers accelerated the sol–gel phase transition of the hydrogel due to the formation of dynamic Schiff-base bonds between the fibers and hydrogels. Furthermore, in combination with UV-assisted crosslinking, a rapid gelation time of 90 s was achieved for the double-crosslinked hydrogels. The addition of APLGA short fibers as fillers and the formation of the double-crosslinking network enhanced the mechanical performance of the hydrogels. Furthermore, the fiber–hydrogel composites exhibited favorable injectability, excellent biocompatibility, and improved cell infiltration. In vivo assessment indicated that the GM/ODex-APLGA hydrogels successfully filled the full-thickness defects and improved wound healing. This work demonstrates a promising solution for the treatment of irregular wounds.

Affiliations:
Wang M. - other affiliation
Du J. - University of California (US)
Li M.S. - Institute of Physics, Polish Academy of Sciences (PL)
Pierini F. - IPPT PAN
Li X. - Donghua University (CN)
Yu J. - Donghua University (CN)
Ding B. - Donghua University (CN)
2.  Liu Y., Wang Q., Liu X., Nakielski P., Pierini F., Li X., Yu J., Ding B., Highly adhesive, stretchable and breathable gelatin methacryloyl-based nanofibrous hydrogels for wound dressings, ACS Applied Bio Materials, ISSN: 2576-6422, DOI: 10.1021/acsabm.1c01087, Vol.5, No.3, pp.1047-1056, 2022

Abstract:
Adhesive and stretchable nanofibrous hydrogels have attracted extensive attraction in wound dressings, especially for joint wound treatment. However, adhesive hydrogels tend to display poor stretchable behavior. It is still a significant challenge to integrate excellent adhesiveness and stretchability in a nanofibrous hydrogel. Herein, a highly adhesive, stretchable, and breathable nanofibrous hydrogel was developed via an in situ hybrid cross-linking strategy of electrospun nanofibers comprising dopamine (DA) and gelatin methacryloyl (GelMA). Benefiting from the balance of cohesion and adhesion based on photocross-linking of methacryloyl (MA) groups in GelMA and the chemical/physical reaction between GelMA and DA, the nanofibrous hydrogels exhibited tunable adhesive and mechanical properties through varying MA substitution degrees of GelMA. The optimized GelMA60-DA exhibited 2.0 times larger tensile strength (2.4 MPa) with an elongation of about 200%, 2.3 times greater adhesive strength (9.1 kPa) on porcine skin, and 3.1 times higher water vapor transmission rate (10.9 kg m–2 d–1) compared with gelatin nanofibrous hydrogels. In parallel, the GelMA60-DA nanofibrous hydrogels could facilitate cell growth and accelerate wound healing. This work presented a type of breathable nanofibrous hydrogels with excellent adhesive and stretchable capacities, showing great promise as wound dressings.

Keywords:
nanofibrous hydrogels, hybrid cross-linking, adhesivity, stretchability, breathable capability

Affiliations:
Liu Y. - Forschugszentrum Jülich, Institute of Complex Systems (DE)
Wang Q. - Donghua University (CN)
Liu X. - Imperial College London (GB)
Nakielski P. - IPPT PAN
Pierini F. - IPPT PAN
Li X. - Donghua University (CN)
Yu J. - Donghua University (CN)
Ding B. - Donghua University (CN)
3.  Wang L., Lv H., Liu L., Zhang Q., Nakielski P., Si Y., Cao J., Li X., Pierini F., Yu J., Ding B., Electrospun nanofiber-reinforced three-dimensional chitosan matrices: architectural, mechanical and biological properties, JOURNAL OF COLLOID AND INTERFACE SCIENCE, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2020.01.016, Vol.565, pp.416-425, 2020

Abstract:
The poor intrinsic mechanical properties of chitosan hydrogels have greatly hindered their practical applications. Inspired by nature, we proposed a strategy to enhance the mechanical properties of chitosan hydrogels by construction of a nanofibrous and cellular architecture in the hydrogel without toxic chemical crosslinking. To this end, electrospun nanofibers including cellulose acetate, polyacrylonitrile, and SiO2 nanofibers were introduced into chitosan hydrogels by homogenous dispersion and lyophilization. With the addition of 30% cellulose acetate nanofibers, the cellular structure could be maintained even in water without crosslinking, and integration of 60% of the nanofibers could guarantee the free-standing structure of the chitosan hydrogel with a low solid content of 1%. Moreover, the SiO2 nanofiber-reinforced chitosan (SiO2 NF/CS) three-dimensional (3D) matrices exhibit complete shape recovery from 80% compressive strain and excellent injectability. The cellular architecture and nanofibrous structure in the SiO2 NF/CS matrices are beneficial for human mesenchymal stem cell adhesion and stretching. Furthermore, the SiO2 NF/CS matrices can also act as powerful vehicles for drug delivery. As an example, bone morphogenetic protein 2 could be immobilized on SiO2 NF/CS matrices to induce osteogenic differentiation. Together, the electrospun nanofiber-reinforced 3D chitosan matrices exhibited improved mechanical properties and enhanced biofunctionality, showing great potential in tissue engineering.

Keywords:
chitosan hydrogel, electrospun nanofiber, mechanical property, nanofibrous matrix, tissue engineering

Affiliations:
Wang L. - Imperial College London (GB)
Lv H. - Medical College of Soochow University (CN)
Liu L. - Donghua University (CN)
Zhang Q. - Medical College of Soochow University (CN)
Nakielski P. - IPPT PAN
Si Y. - Donghua University (CN)
Cao J. - other affiliation
Li X. - Donghua University (CN)
Pierini F. - IPPT PAN
Yu J. - Donghua University (CN)
Ding B. - Donghua University (CN)

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