Institute of Fundamental Technological Research
Polish Academy of Sciences

Partners

M. Spychalski


Recent publications
1.  Miętus M., Kolankowski K., Gołofit T., Denis P., Bandzerewicz A., Spychalski M., Mąkosa-Szczygieł M., Pilarek M., Wierzchowski K., Gadomska-Gajadhur A., From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications, Gels, ISSN: 2310-2861, DOI: 10.3390/gels9100788, Vol.9, No.788, pp.1-19, 2023

Abstract:
Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the synthesis of poly(glycerol itaconate) (PGItc) and preparation of nonwovens based on PGItc gels and polylactide. PGItc gels were synthesized by a reaction between itaconic anhydride and glycerol. The use of a mixture of PGItc and PLA allowed us to obtain a material with different properties than with stand-alone polymers. In this study, we present the influence of the chosen ratios of polymers and the OH/COOH ratio in the synthesized PGItc on the properties of the obtained materials. The addition of PGItc results in hydrophilization of the nonwovens’ surface without disrupting the high porosity of the fibrous structure. Spectral and thermal analyzes are presented, along with SEM imagining. The preliminary cytotoxicity research showed that nonwovens were non-cytotoxic materials. It also helped to pre-determine the potential application of PGItc + PLA nonwovens as subcutaneous tissue fillers or drug delivery systems.

Keywords:
poly(glycerol itaconate), polylactide, electrospinning, tissue engineering, hydrogels

Affiliations:
Miętus M. - other affiliation
Kolankowski K. - other affiliation
Gołofit T. - other affiliation
Denis P. - IPPT PAN
Bandzerewicz A. - Warsaw University of Technology (PL)
Spychalski M. - other affiliation
Mąkosa-Szczygieł M. - other affiliation
Pilarek M. - other affiliation
Wierzchowski K. - other affiliation
Gadomska-Gajadhur A. - Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL)

Patents
Filing No./Date
Filing Publication
Autors
Title
Protection Area, Applicant Name
Patent Number
Date of Grant
pdf
378862
2006-02-01
BUP 16/2007
2007-08-06
Kurzydłowski K., Michalski J., Mikołajek J., Spychalski M., Karniłowicz J., Kukla D., Zagórski A., Spychalski W., Paradowski K.
Device for local freezing of utility in pipes
PL, Materials Engineers Group sp. z o.o.
209367
WUP 08/2011
2011-08-31



Category A Plus

IPPT PAN

logo ippt            Pawińskiego 5B, 02-106 Warsaw
  +48 22 826 12 81 (central)
  +48 22 826 98 15
 

Find Us

mapka
© Institute of Fundamental Technological Research Polish Academy of Sciences 2024