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Polish Academy of Sciences

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Mirosław Wróbel, PhD

Fraunhofer Institute for Cell Therapy and Immunology IZI (DE)
PhD student

Doctoral thesis
2020-01-30 Molecular Acoustic and Advanced Signal Processing Backgrounds of Acoustocerebrography  (Niemcy)
supervisor -- Prof. Andrzej Nowicki, PhD, DSc, IPPT PAN
supervisor -- Robert Olszewski, PhD, DSc, IPPT PAN
co-supervisor -- Prof. Dr. Marcin Lewandowski, IPPT PAN
 

Recent publications
1.  Urbanek-Świderska O., Moczulska-Heljak M., Wróbel M., Mioduszewski A., Kołbuk-Konieczny D., Advanced Graft Development Approaches for ACL Reconstruction or Regeneration, Biomedicines, ISSN: 2227-9059, DOI: 10.3390/biomedicines11020507, Vol.11, No.2, pp.507-1-26, 2023

Abstract:
The Anterior Cruciate Ligament (ACL) is one of the major knee ligaments, one which is greatly exposed to injuries. According to the British National Health Society, ACL tears represent around 40% of all knee injuries. The number of ACL injuries has increased rapidly over the past ten years, especially in people from 26–30 years of age. We present a brief background in currently used ACL treatment strategies with a description of surgical reconstruction techniques. According to the well-established method, the PubMed database was then analyzed to scaffold preparation methods and materials. The number of publications and clinical trials over the last almost 30 years were analyzed to determine trends in ACL graft development. Finally, we described selected ACL scaffold development publications of engineering, medical, and business interest. The systematic PubMed database analysis indicated a high interest in collagen for the purpose of ACL graft development, an increased interest in hybrid grafts, a numerical balance in the development of biodegradable and nonbiodegradable grafts, and a low number of clinical trials. The investigation of selected publications indicated that only a few suggest a real possibility of creating healthy tissue. At the same time, many of them focus on specific details and fundamental science. Grafts exhibit a wide range of mechanical properties, mostly because of polymer types and graft morphology. Moreover, most of the research ends at the in vitro stage, using non-certificated polymers, thus requiring a long time before the medical device can be placed on the market. In addition to scientific concerns, official regulations limit the immediate introduction of artificial grafts onto the market.

Keywords:
ligament,biomaterial,tissue engineering,regeneration,implant,scaffold,synthetic polymer,natural polymer

Affiliations:
Urbanek-Świderska O. - IPPT PAN
Moczulska-Heljak M. - IPPT PAN
Wróbel M. - Fraunhofer Institute for Cell Therapy and Immunology IZI (DE)
Mioduszewski A. - other affiliation
Kołbuk-Konieczny D. - IPPT PAN
2.  Dobkowska-Chudon W., Wróbel M., Frankowska E., Zegadło A., Krupniewicz A., Nowicki A., Olszewski R., Comparison of acoustocerebrography measurement and magnetic resonance imaging methods in the assessment of white matter lesions in patients with atrial fibrillation, ARCHIVES OF ACOUSTICS, ISSN: 0137-5075, DOI: 10.24425/aoa.2020.134060, Vol.45, No.3, pp.445-452, 2020

Abstract:
The brain is subject to damage, due to ageing, physiological processes and/or disease. Some of the damage is acute in nature, such as strokes; some is more subtle, like white matter lesions. White matter lesions or hyperintensities (WMH) can be one of the first signs of micro brain damage. We implemented the Acoustocerebrography (ACG) as an easy to use method designed to capture differing states of human brain tissue and the respective changes. Aim: The purpose of the study is to compare the efficacy of ACG and Magnetic Resonance Imaging (MRI) to detect WMH in patients with clinically silent atrial fibrillation (AF). Methods and results: The study included 97 patients (age 66.26 ± 6.54 years) with AF. CHA2DS2- VASc score (2.5 ±1.3) and HAS BLED (1.65 ± 0.9). According to MRI data, the patients were assigned into four groups depending on the number of lesions: L0 – 0 to 4 lesions, L5 – 5 to 9 lesions, L10 – 10 to 29 lesions, and L30 – 30 or more lesions. Authors found that the ACG method clearly differentiates the groups L0 (with 0–4 lesions) and L30 (with more than 30 lesions) of WMH patients. Fisher's Exact Test shows that this correlation is highly significant (p < 0.001). Conclusion: ACG is a new, easy and cost-effective method for detecting WMH in patients with atrial fibrillation. The ACG measurement methodology should become increasingly useful for the assessment of WMH.

Keywords:
acoustocerebrography, brain MRI, atrial fibrillation, white matter hyperintensities

Affiliations:
Dobkowska-Chudon W. - District Hospital (PL)
Wróbel M. - Fraunhofer Institute for Cell Therapy and Immunology IZI (DE)
Frankowska E. - Military Medical Institute (PL)
Zegadło A. - other affiliation
Krupniewicz A. - Medical University of Warsaw (PL)
Nowicki A. - IPPT PAN
Olszewski R. - IPPT PAN

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