| 1. |
Edith D.♦, David O. O.♦, Nwaji N.♦, Earl P.♦, Tebello N.♦, Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles.,
Photodiagnosis and Photodynamic Therapy, ISSN: 1572-1000, DOI: 10.1016/j.pdpdt.2019.01.019, Vol.25, pp.Photodiagnosis and Photodynamic Therapy-325, 2019 Abstract:
This work reports on the linkage of 2(3),9(10),16(17),23(24) tetrakis [(benzo[d]thiazol-2-yl phenoxy) phthalocyaninato] zinc(II) (1) and indium(III) chloride (2) to gold speckled silica (GSS) nanoparticles via gold to
sulphur (Au-S) and gold to nitrogen (Au-N) self-assembly to form the conjugates: 1-GSS and 2-GSS. The formed
conjugates were characterized using microscopic and spectroscopic techniques, and the photophysicochemical
properties and photodynamic therapy (PDT) activity against human breast adenocarcinoma cell line (MCF-7
cells) were studied. The conjugates afforded decrease in fluorescence quantum yields with corresponding increase in triplet and singlet oxygen quantum yields when compared to phthalocyanines alone. Singlet oxygen is
cytotoxic to cancer cells hence it is important for PDT. The in vitro dark toxicity of complex 2 and 2-GSS against
MCF–7 cells showed ≥93% viable cells within concentration ranges of 10–160 μg/mL. 2–GSS showed enhanced
PDT activity with less than 50% viable cells at 80 μg/mL as compared to 2 and GSS alone which showed > 60%
viable cells within 10–160 μg/mL. The observed improvements in the PDT activity of 2-GSS could be attributed
to the high singlet oxygen generation of 2-GSS compared to 2 alone in addition to the phototoxicity of GSS. Affiliations:
| Edith D. | - | other affiliation | | David O. O. | - | other affiliation | | Nwaji N. | - | other affiliation | | Earl P. | - | other affiliation | | Tebello N. | - | other affiliation |
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| 2. |
Refilwe M.♦, Nwaji N., Muthumuni M.♦, Earl P.♦, Tebello N.♦, Effect of number of positive charges on the photophysical and photodynamic therapy activities of quarternary benzothiazole substituted zinc phthalocyanine,
Journal of Photochemistry and Photobiology A, ISSN: 1010-6030, Vol.367, pp.Journal of Photochemistry and Photobiology A: Chemistry-253, 2018Abstract:
The synthesis, photophysicochemical and photodynamic therapy (PDT) activity of quaternary benzothiazole substituted zinc phthalocyanine (2, containing two charges, and 3, containing four charges) are reported in this work. Furthermore, the activity of the synthesized complex was compared to non-quaternary derivative (1). Higher triplet and singlet oxygen quantum yields of 0.92 and 0.85, respectively, for quaternized complexes 2 and 3 compared to complex 1 alone. Complexes 1, 2 and 3 showed relatively no dark toxicity against the epithelial breast cancer cells with cell survival of above 90 ± 3%. The quaternary derivatives (2 and 3) showed superior PDT activity with 30% or less of viable cells at concentration of 50.0 μg/mL in comparison to complex 1 alone which further lay credence to the importance of quaternization in the enhancement of PDT activit Affiliations:
| Refilwe M. | - | other affiliation | | Nwaji N. | - | IPPT PAN | | Muthumuni M. | - | other affiliation | | Earl P. | - | other affiliation | | Tebello N. | - | other affiliation |
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