Institute of Fundamental Technological Research
Polish Academy of Sciences

Partners

A. Krupienicz

Medical University of Warsaw (PL)


Recent publications
1.  Dobkowska-Chudon W., Wrobel M., Karłowicz P., Dabrowski A., Krupienicz A., Targowski T., Nowicki A., Olszewski R., Detecting cerebrovascular changes in the brain caused by hypertension in atrial fibrillation group using acoustocerebrography, PLOS ONE, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0199999, Vol.13, No.7, pp.1-10, 2018

Abstract:
Acoustocerebrography is a novel, non-invasive, transcranial ultrasonic diagnostic method based on the transmission of multispectral ultrasound signals propagating through the brain tissue. Dedicated signal processing enables the estimation of absorption coefficient, frequency-dependent attenuation, speed of sound and tissue elasticity. Hypertension and atrial fibrillation are well known factors correlated with white matter lesions, intracerebral hemorrhage and cryptogenic stroke numbers. The aim of this study was to compare the acoustocerebrography signal in the brains of asymptomatic atrial fibrillation patients with and without hypertension. The study included 97 asymptomatic patients (40 female and 57 male, age 66.26 +/- 6.54 years) who were clinically monitored for atrial fibrillation. The patients were divided into two groups: group I (patients with hypertension) n = 75, and group II (patients without hypertension) n = 22. Phase and amplitude of all spectral components for the received signals from the brain path were extracted and compared to the phase and amplitude of the transmitted pulse. Next, the time of flight and the attenuation of each frequency component were calculated. Additionally, a fast Fourier transformation was performed and its features were extracted. After introducing a machine learning technique, the ROC plot of differentiations between group I and group II with an AUC of 0.958 (sensitivity 0.99 and specificity 0.968) was obtained. It can be assumed that the significant difference in the acoustocerebrography signals in patients with hypertension is due to changes in the brain tissue, and it allows for the differentiating of high-risk patients with asymptomatic atrial fibrillation and hypertension.

Keywords:
changes in the brain, hypertension in atrial, acoustocerebrography

Affiliations:
Dobkowska-Chudon W. - District Hospital (PL)
Wrobel M. - Sonovum A.G. (DE)
Karłowicz P. - Sonomed Sp. z o.o. (PL)
Dabrowski A. - MTZ Clinical Research (PL)
Krupienicz A. - Medical University of Warsaw (PL)
Targowski T. - National Institute of Geriatrics, Rheumatology and Rehabilitation (PL)
Nowicki A. - IPPT PAN
Olszewski R. - IPPT PAN
2.  Wilczek M.M., Olszewski R., Krupienicz A., Cardiovascular disease and trans fatty acids: legal act necessary, POLSKI MERKURIUSZ LEKARSKI, ISSN: 1426-9686, Vol.44, No.260, pp.71-74, 2018

Abstract:
Hydrogenated oils containing trans fatty acids (TFA) are used to produce margarine and various processed foods. TFA affect serum lipid levels, fatty acids metabolism, and endothelial function. High TFA intake is linked to increased all-cause mortality, coronary heart disease mortality and cardiovascular disease (CVD) incidence. Denmark was first to introduce law that limited TFA content in food; this action led to lower CVD mortality. Seven European countries have followed this practice until now, in a few others the food industry voluntarily reduced TFA use. The issue remains unaddressed in Poland. Legal TFA limit should be established, as it is the optimal solution considering both CVD prevention and the associated cost savings in public healthcare.

Keywords:
Poland, cardiovascular disease, nutrition policy, trans fatty acids

Affiliations:
Wilczek M.M. - Poznan University of Medical Sciences (PL)
Olszewski R. - IPPT PAN
Krupienicz A. - Medical University of Warsaw (PL)
3.  Wilczek M.M., Olszewski R., Krupienicz A., Trans -Fatty Acids and Cardiovascular Disease: Urgent Need for Legislation, CARDIOLOGY, ISSN: 0008-6312, DOI: 10.1159/000479956, Vol.138, No.4, pp.254-258, 2017

Abstract:
Hydrogenated oils containing trans -fatty acids (TFA) are used to produce margarine and various processed foods. TFA affect serum lipid levels, fatty acid metabolism, and endothelial function. High TFA intake is linked to increased allcause mortality, coronary heart disease mortality, and cardiovascular disease (CVD) incidence. Denmark was the first country to introduce a law that limited TFA content in food; this action led to lower CVD mortality. So far 7 European countries have followed this practice, in a few others the food industry voluntarily reduced TFA use. The issue remains mostly unaddressed in the rest of the world. Legal TFA limits should be commonly established as they are the optimal solution considering both CVD prevention and the associated cost savings in public healthcare.

Keywords:
Trans -fatty acids, Cardiovascular disease, Nutrition policy

Affiliations:
Wilczek M.M. - Poznan University of Medical Sciences (PL)
Olszewski R. - IPPT PAN
Krupienicz A. - Medical University of Warsaw (PL)
4.  Majka K., Krupienicz A., Olszewski R., Telepielęgniarstwo w ortopedii, Medycyna Ogólna i Nauki o Zdrowiu, ISSN: 2083-4543, DOI: 10.26444/monz/75509, Vol.23, No.2, pp.94-97, 2017

Abstract:
Wprowadzenie i cel pracy. Rozwój technologii informacyjno-komunikacyjnej może doprowadzić do poprawy sytuacji w służbie zdrowia. Telepielęgniarstwo pozwoli na rozszerzenie praktyki pielęgniarskiej oraz wielu funkcji takich jak: opiekuńczo-pielęgnacyjna, profilaktyczna, diagnostyczna, rehabilitacyjna i związana z promocją zdrowia. Celem pracy jest ukazanie telepielęgniarstwa w ortopedii, a także zaprezentowanie wielu korzyści, jakie niesie zarówno dla pacjenta, jak i dla personelu medycznego. Skrócony opis stanu wiedzy. Starzejące się społeczeństwo potrzebuje zarówno wykwalifikowanego personelu pielęgniarskiego, jak i możliwości uzyskania szybkiej konsultacji lekarskiej i pielęgniarskiej. Udzielanie wskazówek, porad i opieki pielęgniarskiej przez pielęgniarki specjalistki w swej profesji m.in. za pomocą wideokonferencji przysporzy znaczących korzyści zarówno pacjentom, lekarzom, pielęgniarkom, jak i rehabilitantom. Podsumowanie. Wdrożenie wirtualnych wizyt może doprowadzić do poprawy sytuacji w ochronie zdrowia. Telepielęgniarstwo rozszerzyłoby kompetencje pielęgniarki, a także podniosłoby jakość świadczonych przez nie usług. Być może zatrzymałoby również emigrację zarobkową pielęgniarek w Polsce.

Keywords:
telepielęgniarstwo, ortopedia, edukacja pacjenta, nowe technologie, kształcenie, niedobór personelu pielęgniarskiego

Affiliations:
Majka K. - Military Medical Institute (PL)
Krupienicz A. - Medical University of Warsaw (PL)
Olszewski R. - IPPT PAN

Conference abstracts
1.  Parol M.A., Majka K., Trawiński Z., Gambin B., Krupienicz A., Obiala J., Nowicki A., Olszewski R., Ultrasonic imaging of radial artery reactive response in patients with hypertension with and without left ventricular hypertrophy, EuroEcho 2019, EuroEcho 2019 Congress of the European Association of Cardiovascular Imaging (EACVI). , 2019-12-04/12-07, Vienna (AT), DOI: 10.1093/ehjci/jez319.1176, Vol.21, No.Suplement 1, pp.i1239-i1239, 2020
2.  Olszewski R., Dobkowska-Chudon W., Wrobel M., Karlowicz P., Dabrowski A., Krupienicz A., Targowski T., Nowicki A., Is Acoustocerebrography a new noninvasive method for early detection of the brain changes in patients with hypertension?, ESC Congress 2017, European Society of Cardiology Congress 2017, 26-30 August, Barcelona, Spain, 2017-08-26/08-30, Barcelona (ES), DOI: 10.1093/eurheartj/ehx501.P190, Vol.38, No.suppl_1, pp.36, 2017

Abstract:
Background: Hypertension (HT) is the leading cause of global disease burden and overall health loss. The brain is one of the main target organs affected by HT. HT is a potentially modifiable risk factor that leads to the formation of large vessel macroangiopathy, small vessel disease, microangiopathy, and microhemorrhages. Early detection of the brain changes (BC) gives a chance to receive appropriate treatment and protection from irreversible damage. Acoustocerebrography (ACG) is a set of techniques to capture the states of human brain tissue, and its changes on its molecular and cellular level. It is based on noninvasive measurements of various parameters obtained by analyzing an ultrasound pulse emitted across the human's skull. The main idea of this method relies in the relation between the tissue density, bulk modulus, and speed of propagation, for ultrasound waves in this medium. In our previous studies we showed that ACG is an effective method for detecting white matter lesions compared to the Magnetic Resonance Imaging. Additionally we showed that ACG allows to obtain a differentiated signal originates from atrial fibrillation (AF) patients and high-risk patients wit AF and HT.
Aim: The aim of the study was early detection of the BC in patients with HT using ACG.
Methods: The study included 136 female and 98 male patients (age 43.6±15.7 years) who were surveyed in the clinical research. The patients were divided into two groups: group I (patients with HT) n=33, and control group II (patients without HT) n=201. Phase and amplitude of all frequency components of the received signals from the brain path were extracted and compared to the phase and amplitude of the transmitted pulse. By doing so, the time of flight and the attenuation of each frequency component were calculated. Additionally, a fast Fourier transformation (FFT) was performed and its features were extracted.
Results: After introducing a machine learning technique, the ROC plot with an AUC of 0.929 with sensitivity 0.879 and specificity 0.831 was obtained (Fig. 1).
Conclusion: ACG is new promising method, which allows for early detection of change in the brain in the patients with HT.

Affiliations:
Olszewski R. - IPPT PAN
Dobkowska-Chudon W. - District Hospital (PL)
Wrobel M. - Sonovum A.G. (DE)
Karlowicz P. - Sonomed Sp. z o.o. (PL)
Dabrowski A. - MTZ Clinical Research (PL)
Krupienicz A. - Medical University of Warsaw (PL)
Targowski T. - National Institute of Geriatrics, Rheumatology and Rehabilitation (PL)
Nowicki A. - IPPT PAN

Patents
Filing No./Date
Filing Publication
Autors
Title
Protection Area, Applicant Name
Patent Number
Date of Grant
pdf
427853
2018-11-21
BUP 12/2020
2020-06-01
Olszewski R., Krupienicz A.
Elektroda wewnątrzsercowa/cewnik do stymulacji serca i podawania leków
PL, Instytut Podstawowych Problemów Techniki PAN
237439
WUP 08/2021
2021-04-19

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