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Polish Academy of Sciences

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A. Yarin

Technion-Israel Institute of Technology (IL)

Recent publications
1.  Nakielski P., Pawłowska S., Rinoldi C., Ziai Y., De Sio L., Urbanek O., Zembrzycki K., Pruchniewski M., Lanzi M., Salatelli E., Calogero A., Kowalewski T.A., Yarin A.L., Pierini F., Multifunctional platform based on electrospun nanofibers and plasmonic hydrogel: a smart nanostructured pillow for near-Infrared light-driven biomedical applications, ACS Applied Materials and Interfaces, ISSN: 1944-8244, DOI: 10.1021/acsami.0c13266, Vol.12, No.49, pp.54328-54342, 2020

Abstract:
Multifunctional nanomaterials with the ability torespond to near-infrared (NIR) light stimulation are vital for thedevelopment of highly efficient biomedical nanoplatforms with apolytherapeutic approach. Inspired by the mesoglea structure ofjellyfish bells, a biomimetic multifunctional nanostructured pillowwith fast photothermal responsiveness for NIR light-controlled on-demand drug delivery is developed. We fabricate a nanoplatformwith several hierarchical levels designed to generate a series ofcontrolled, rapid, and reversible cascade-like structural changesupon NIR light irradiation. The mechanical contraction of thenanostructured platform, resulting from the increase of temper-ature to 42°C due to plasmonic hydrogel−light interaction, causesa rapid expulsion of water from the inner structure, passing through an electrospun membrane anchored onto the hydrogel core. Themutual effects of the rise in temperature and waterflow stimulate the release of molecules from the nanofibers. To expand thepotential applications of the biomimetic platform, the photothermal responsiveness to reach the typical temperature level forperforming photothermal therapy (PTT) is designed. The on-demand drug model penetration into pig tissue demonstrates theefficiency of the nanostructured platform in the rapid and controlled release of molecules, while the high biocompatibility confirmsthe pillow potential for biomedical applications based on the NIR light-driven multitherapy strategy.

Keywords:
bioinspired materials, NIR-light responsive nanomaterials, multifunctional platforms, electrospun nanofibers, plasmonic hydrogel, photothermal-based polytherapy, on-demand drug delivery

Affiliations:
Nakielski P. - IPPT PAN
Pawłowska S. - IPPT PAN
Rinoldi C. - IPPT PAN
Ziai Y. - IPPT PAN
De Sio L. - Sapienza University of Rome (IT)
Urbanek O. - IPPT PAN
Zembrzycki K. - IPPT PAN
Pruchniewski M. - other affiliation
Lanzi M. - University of Bologna (IT)
Salatelli E. - University of Bologna (IT)
Calogero A. - Sapienza University of Rome (IT)
Kowalewski T.A. - IPPT PAN
Yarin A.L. - Technion-Israel Institute of Technology (IL)
Pierini F. - IPPT PAN
2.  Sankaran A., Pawłowska S., Pierini F., Kowalewski T.A., Yarin A.L., Dynamics of electrospun hydrogel filaments in oscillatory microchannel flows: a theoretical and experimental approach, PHYSICS OF FLUIDS, ISSN: 1070-6631, DOI: 10.1063/5.0011005, Vol.32, No.7, pp.072008-1-13, 2020

Abstract:
The dynamics of highly flexible micro- and nano-filaments are important to a variety of biological, medical, and industrial problems. The filament configuration variation and cross-stream migration in a microchannel are affected by thermal fluctuations in addition to elastic and viscous forces. Here, hydrogel nano-filaments with small bending Young's moduli are utilized to elucidate the transitional behavior of elastic Brownian filaments in an oscillatory microchannel flow. A numerical model based on chain elastic dumbbells similar to the Rouse-Zimm model accounting for elastic, viscous, and random Brownian forces is proposed and implemented. In addition, a theoretical model to describe the average orientation–deformation tensor evolution for an ensemble of filaments in an oscillatory flow is proposed. The results are compared with the evolution observed in the experiments.

Affiliations:
Sankaran A. - other affiliation
Pawłowska S. - IPPT PAN
Pierini F. - IPPT PAN
Kowalewski T.A. - IPPT PAN
Yarin A.L. - Technion-Israel Institute of Technology (IL)
3.  Yarin A., Kowalewski T.A., Hiller W.J., Koch St., Distribution of particles suspended in convective flow in differentially heated cavity, PHYSICS OF FLUIDS, ISSN: 1070-6631, DOI: 10.1063/1.868913, Vol.8, No.5, pp.1130-1140, 1996

Abstract:
Our aim is to explore, both experimentally and theoretically, the cumulative effects of small particle–liquid density difference, where the particles are used as tracers in recirculating flow. As an example we take a flow field generated in a differentially heated cavity. The main flow structure in such a cavity consists in one or two spiraling motions. Long‐term observations of such structures with the help of tracers (small particles) indicated that accumulation of the particles may set in at some flow regions. For theoretical insight into the phenomenon, a simple analytical model of recirculating (rotating) flow was studied. It was assumed that particles are spherical and rigid, and their presence does not affect the flow field. The particle Reynolds number is negligibly small, hence only the effects of particle–liquid density difference are of importance. Besides buoyancy, the effects of Saffman’s force and the inertial forces are also taken into account when calculating particle trajectories. Both cases were analyzed, particles with density slightly higher and lower than the fluid. It was found that in our case the inertial forces are egligible. In the numerical experiment trajectories of particles were investigated. The particles were allocated at random in the flow field obtained by numerical solution of the natural convection in the differentially heated cavity. In the experimental part, behavior of a dilute particle suspension in the convective cell was explored. In the model‐analytical study of a simple spiraling motion, it was found that due to the interaction of the recirculating convective flow field and the gravity‐buoyancy force, the particles may be trapped in some flow regions, whereas the rest of the flow field becomes particle‐free. This prediction agrees fairly well with the numerical and experimental findings.

Affiliations:
Yarin A. - Technion-Israel Institute of Technology (IL)
Kowalewski T.A. - IPPT PAN
Hiller W.J. - Max-Planck-Institut für Strömungsforschung (DE)
Koch St. - Max-Planck-Institut für Strömungsforschung (DE)

Conference abstracts
1.  Pierini F., Nakielski P., Pawłowska S., Rinoldi C., Ziai Y., Urbanek-Świderska O., De Sio L., Calogero A., Lanzi M., Zembrzycki K., Pruchniewski M., Salatelli E., Kowalewski T.A., Yarin A., Nature-inspired smart drug delivery platforms based on electrospun nanofibers and plasmonic hydrogels for near-infrared light-controlled polytherapy, Polymer Connect, Polymer Science and Composite Materials Conference, 2020-02-26/02-28, LISBON (PT), pp.7, 2020

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