Institute of Fundamental Technological Research
Polish Academy of Sciences


Mateusz Skomorowski

Recent publications
1.  Nakielski P., Rybak D., Jezierska-Woźniak K., Rinoldi C., Sinderewicz E., Staszkiewicz-Chodor J., Haghighat Bayan Mohammad A., Czelejewska W., Urbanek-Świderska O., Kosik-Kozioł A., Barczewska M., Skomorowski M., Holak P., Lipiński S., Maksymowicz W., Pierini F., Minimally invasive intradiscal delivery of BM-MSCs via fibrous microscaffold carriers, ACS Applied Materials and Interfaces, ISSN: 1944-8244, DOI: 10.1021/acsami.3c11710, pp.1-16, 2023

Current treatments of degenerated intervertebral discs often provide only temporary relief or address specific causes, necessitating the exploration of alternative therapies. Cell-based regenerative approaches showed promise in many clinical trials, but
limitations such as cell death during injection and a harsh disk environment hinder their effectiveness. Injectable microscaffolds offer a solution by providing a supportive microenvironment for cell delivery and enhancing bioactivity. This study evaluated the
safety and feasibility of electrospun nanofibrous microscaffolds modified with chitosan (CH) and chondroitin sulfate (CS) for treating degenerated NP tissue in a large animal model. The microscaffolds facilitated cell attachment and acted as an effective delivery system, preventing cell leakage under a high disc pressure. Combining microscaffolds with bone marrow-derived mesenchymal stromal cells demonstrated no cytotoxic effects and proliferation over the entire microscaffolds. The administration of cells attached to microscaffolds into the NP positively influenced the regeneration process of the intervertebral disc. Injectable poly(L-lactide-co-glycolide) and poly(L-lactide) microscaffolds enriched with CH or CS, having a fibrous structure, showed the potential to promote intervertebral disc regeneration. These features collectively address critical challenges in the fields of tissue engineering and regenerative medicine, particularly in the context of intervertebral disc degeneration.

microscaffolds,cell carriers,injectable biomaterials,intervertebral disc,laser micromachining,electrospinning

Nakielski P. - IPPT PAN
Rybak D. - IPPT PAN
Jezierska-Woźniak K. - other affiliation
Rinoldi C. - IPPT PAN
Sinderewicz E. - other affiliation
Staszkiewicz-Chodor J. - other affiliation
Haghighat Bayan Mohammad A. - IPPT PAN
Czelejewska W. - other affiliation
Urbanek-Świderska O. - IPPT PAN
Kosik-Kozioł A. - IPPT PAN
Barczewska M. - University of Warmia and Mazury in Olsztyn (PL)
Skomorowski M. - other affiliation
Holak P. - other affiliation
Lipiński S. - other affiliation
Maksymowicz W. - University of Warmia and Mazury in Olsztyn (PL)
Pierini F. - IPPT PAN

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