Institute of Fundamental Technological Research
Polish Academy of Sciences

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W. Sikorska


Recent publications
1.  Wasyleczko M., Sikorska W., Przytulska M., Dulnik J., Chwojnowski A., Polyester membranes as 3D scaffolds for cell culture, Desalination and Water Treatment, ISSN: 1944-3994, DOI: 10.5004/dwt.2021.26658, Vol.214, pp.181-193, 2021

Abstract:
The study presents two types of three-dimensional membranes made of the biodegradable copolymer. They were obtained by the wet-phase inversion method using different solvent and pore precursors. In one case, a nonwoven made of gelatin and polyvinylpyrrolidone (PVP) as precursors of macropores and small pores, respectively, were used. In the second case, PVP nonwovens and Pluronic were used properly for macro- and micro-pores. As the material, a biodegradable poly(L-lactide-co-ε-caprolactone) is composed of 30% ε-caprolactone and 70% poly(L-lactic acid) was used. Depending on the pore precursors, different membrane structures were obtained. The morphology of pores was studied using the MeMoExplorer™, an advanced software designed for computer analysis of the scanning electron microscopy images. The scaffolds were degraded in phosphate-buffered saline and Hank’s balanced salt solutions at 37°C. Moreover, the porosity of the membranes before and after hydrolysis was calculated.

Keywords:
3D scaffolds, poly(L-lactide-co-ε-caprolactone), porosity of membrane, phase inversion method, degradation of scaffolds

Affiliations:
Wasyleczko M. - other affiliation
Sikorska W. - other affiliation
Przytulska M. - other affiliation
Dulnik J. - IPPT PAN
Chwojnowski A. - Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL)
2.  Sajkiewicz P., Brzeska J., Denis P., Sikorska W., Kowalczuk M., Rutkowska M., The preliminary studies of a structure and electrospinning of new polyurethanes based on synthetic atactic poly[(R, S)-3-hydroxybutyrate], BULLETIN OF THE POLISH ACADEMY OF SCIENCES: TECHNICAL SCIENCES, ISSN: 0239-7528, DOI: 10.2478/bpasts-2014-0006, Vol.62, No.1, pp.55-60, 2014

Abstract:
Novel polyurethanes based on synthetic, atactic poly[(R, S)-3-hydroxybutyrate] (a-PHB) and polycaprolactone (PCL) or polyoxytetramethylene (PTMG) diols were synthesized. It was shown that the presence of a-PHB within soft segments reduces crystallinity of PUR. Because of the low melting temperature for polyurethanes with PCL in soft segments, at this stage of work, electrospinning was limited to polyurethanes containing PTMG and a-PHB. Polyurethane containing 80% of PTMG and 20% of a-PHB was electrospun at various parameters from hexafluoro-2-propanole solution, resulting in formation of fibers with the average diameter ca. 2 μm. The fiber diameter decreased with decreasing polymer concentration in a solution and was practically insensitive to the needle-collector distance in the applied range of distances.

Keywords:
polyurethane, polyhydroxybutyrate, electrospinning, scaffolds

Affiliations:
Sajkiewicz P. - IPPT PAN
Brzeska J. - other affiliation
Denis P. - IPPT PAN
Sikorska W. - other affiliation
Kowalczuk M. - other affiliation
Rutkowska M. - other affiliation

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