Institute of Fundamental Technological Research
Polish Academy of Sciences


Juan Redondo Marin, PhD

Department of Biosystems and Soft Matter (ZBiMM)
Division of Modelling in Biology and Medicine (PMBM)
position: Assistant Professor
telephone: (+48) 22 826 12 81 ext.: 318
room: 226B
ORCID: 0000-0002-9280-9848

Doctoral thesis
2013-01-01 New cationic copolymers with applications in gene therapy 
supervisor -- Prof. Dr. Carlos Elvira Pujalte, ICTP CSIC
supervisor -- Prof. Dr. Alberto Gallardo Ruiz, ICTP CSIC
supervisor -- Prof. Dr. Helmut Reinecke, ICTP CSIC

Recent publications
1.  Redondo Juan A., Bibes R., Vercauteren Drubbel A., Dassy B., Bisteau X., Maury E., Beck B., PER2 Circadian Oscillation Sensitizes Esophageal Cancer Cells to Chemotherapy, Biology, ISSN: 2079-7737, DOI: 10.3390/biology10040266, Vol.10, No.4, pp.266-1-18, 2021

Esophageal squamous cell carcinoma (eSCC) accounts for more than 85% cases of esophageal cancer worldwide and the 5-year survival rate associated with metastatic eSCC is poor. This low survival rate is the consequence of a complex mechanism of resistance to therapy and tumor relapse. To effectively reduce the mortality rate of this disease, we need to better understand the molecular mechanisms underlying the development of resistance to therapy and translate that knowledge into novel approaches for cancer treatment. The circadian clock orchestrates several physiological processes through the establishment and synchronization of circadian rhythms. Since cancer cells need to fuel rapid proliferation and increased metabolic demands, the escape from circadian rhythm is relevant in tumorigenesis. Although clock related genes may be globally repressed in human eSCC samples, PER2 expression still oscillates in some human eSCC cell lines. However, the consequences of this circadian rhythm are still unclear. In the present study, we confirm that PER2 oscillations still occur in human cancer cells in vitro in spite of a deregulated circadian clock gene expression. Profiling of eSCC cells by RNAseq reveals that when PER2 expression is low, several transcripts related to apoptosis are upregulated. Consistently, treating eSCC cells with cisplatin when PER2 expression is low enhances DNA damage and leads to a higher apoptosis rate. Interestingly, this process is conserved in a mouse model of chemically-induced eSCC ex vivo. These results therefore suggest that response to therapy might be enhanced in esophageal cancers using chronotherapy.

circadian clock, esophagus cancer, squamous cell carcinoma, apoptosis, chemotherapy, chronotherapy

Redondo Juan A. - IPPT PAN
Bibes R. - other affiliation
Vercauteren Drubbel A. - other affiliation
Dassy B. - other affiliation
Bisteau X. - other affiliation
Maury E. - other affiliation
Beck B. - other affiliation

Category A Plus


logo ippt            Pawińskiego 5B, 02-106 Warsaw
  +48 22 826 12 81 (central)
  +48 22 826 98 15

Find Us

© Institute of Fundamental Technological Research Polish Academy of Sciences 2024