Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk

Partnerzy

Dorota Nieciecka


Ostatnie publikacje
1.  Osial M., Ha G., Vu V., Nguyen P., Nieciecka D., Pietrzyk‑Thel P., Urbanek O., Olusegun S., Wilczewski S., Giersig M., Do H., Dinh T., One-pot synthesis of magnetic hydroxyapatite (SPION/HAp) for 5-fluorouracil delivery and magnetic hyperthermia, Journal of Nanoparticle Research, ISSN: 1388-0764, DOI: 10.1007/s11051-023-05916-x, Vol.26, No.7, pp.1-23, 2024

Streszczenie:
This work presents the synthesis and characterization of a composite made of superparamagnetic iron oxide and hydroxyapatite nanoparticles (SPION/HAp) with a well-developed surface for loading anticancer drugs and for use in magnetic hyperthermia and local chemotherapy. The proposed material was obtained by an easy one-pot co-precipitation method with a controlled ratio of SPION to HAp. The morphology was studied by SEM and TEM, indicating rod-like structures for high HAp content in the composite and granule-like structures with increasing SPION. Its crystallinity, elemental composition, and functional groups were determined by X-ray diffraction, EDS, and FT-IR, respectively. The nanocomposite was then stabilized with citrates (CA), polyethylene glycol (PEG), and folic acid (FA) as agents to improve intracellular absorption, while turbidimetric studies confirmed that only citrates effectively stabilized the magnetic carriers to form a colloidal suspension. Subsequently, 5-fluorouracil (5-FU) was loaded into the magnetic carriers and tested in vitro using the L-929 cell line. The studies showed no cytotoxicity of the citrate-stabilized suspension against fibroblasts and some cytotoxicity after 5-FU release. In addition to in vitro studies, the composite was also tested on biomimetic membranes made of DOPC, DOPE, cholesterol, and DOPS lipids using Langmuir trough. The results show that the resulting suspension interacts with biomimetic membranes, while magnetic hyperthermia studies confirm effective heat generation to achieve therapeutic 42–46 °C and improve drug release from magnetic carriers.

Słowa kluczowe:
SPION, Hydroxyapatite, Magnetic hyperthermia, Drug delivery, 5-fluorouracil, Biomimetic membranes, Nanostructures, Cancer treatment

Afiliacje autorów:
Osial M. - IPPT PAN
Ha G. - inna afiliacja
Vu V. - inna afiliacja
Nguyen P. - inna afiliacja
Nieciecka D. - inna afiliacja
Pietrzyk‑Thel P. - IPPT PAN
Urbanek O. - IPPT PAN
Olusegun S. - inna afiliacja
Wilczewski S. - inna afiliacja
Giersig M. - IPPT PAN
Do H. - inna afiliacja
Dinh T. - inna afiliacja
70p.
2.  Osial M., Wilczewski S., Szulc J., Nguyen Hai D., Nguyen Thi Kieu O., Skórczewska K., Majkowska-Pilip A., Żelechowska-Matysiak K., Nieciecka D., Pręgowska A., Nguyen Thu P., Tymoszuk A., Kulus D., Giersig M., Nanohydroxyapatite Loaded with 5-Fluorouracil and Calendula officinalis L. Plant Extract Rich in Myo-Inositols for Treatment of Ovarian Cancer Cells, Coatings, ISSN: 2079-6412, DOI: 10.3390/coatings13111944, Vol.13, No.1944, pp.1-21, 2023

Słowa kluczowe:
hydroxyapatite, myo-inositol, 5-fluorouracil, anticancer treatment, SKOV-3, calendula extract, Langmuir trough

Afiliacje autorów:
Osial M. - IPPT PAN
Wilczewski S. - inna afiliacja
Szulc J. - inna afiliacja
Nguyen Hai D. - inna afiliacja
Nguyen Thi Kieu O. - inna afiliacja
Skórczewska K. - inna afiliacja
Majkowska-Pilip A. - inna afiliacja
Żelechowska-Matysiak K. - inna afiliacja
Nieciecka D. - inna afiliacja
Pręgowska A. - IPPT PAN
Nguyen Thu P. - inna afiliacja
Tymoszuk A. - inna afiliacja
Kulus D. - inna afiliacja
Giersig M. - IPPT PAN
100p.
3.  Nguyen Phuong T., Wilczewski S., Lewandowski J., Majkowska-Pilip A., Żelechowska-Matysiak K., Nieciecka D., Studziński W., Olusegun Joseph S., Syczewski M., Giersig M., Dinh Thi Mai T., Krysiński P., Osial M., 5-fluorouracil and curcuminoids extract from Curcuma longa L. loaded into nanohydroxyapatite as a drug delivery carrier for SKOV-3 and HepG2 cancer cells treatment, CERAMICS INTERNATIONAL, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2023.05.123, pp.1-13, 2023

Słowa kluczowe:
Drug delivery, Hydroxyapatite, Anticancer, 5-fluorouracil, Curcuminoids, Nanocomposite

Afiliacje autorów:
Nguyen Phuong T. - inna afiliacja
Wilczewski S. - inna afiliacja
Lewandowski J. - inna afiliacja
Majkowska-Pilip A. - inna afiliacja
Żelechowska-Matysiak K. - inna afiliacja
Nieciecka D. - inna afiliacja
Studziński W. - inna afiliacja
Olusegun Joseph S. - inna afiliacja
Syczewski M. - inna afiliacja
Giersig M. - IPPT PAN
Dinh Thi Mai T. - inna afiliacja
Krysiński P. - inna afiliacja
Osial M. - IPPT PAN
100p.
4.  Olusegun S., Osial M., Majkowska-Pilip A., Żelechowska-Matysiak K., Nieciecka D., Krajewski M., Pękała M., Krysiński P., Synthesis and characterization of Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery application, CERAMICS INTERNATIONAL, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2023.03.102, pp.1-10, 2023

Streszczenie:
Commendable efforts have been gingered towards the fight against cancer. Nevertheless, it remains a major public health concern due to its predominant cause of death globally. Given this, we synthesized two different nanoparticles, Sr2+ and Gd3+ doped magnetite for magnetic hyperthermia and drug delivery application. Based on the characterization, the diffractogram shows that only one phase related to magnetite with a crystallite size of 10 nm was formed. TEM images revealed nanoparticles of spherical shapes of approximately 12 nm. There is no difference in magnetic saturation of the as-received synthesized samples (Fe3O4@Sr and Fe3O4@Gd), while the BET-specific surface area of Fe3O4@Gd is 8 m2 g−1 higher than Fe3O4@Sr. The heat generation in alternating magnetic field (the magnetic hyperthermia) of Fe3O4@Sr functionalized with citric acid and loaded with 5- fluorouracil (Fe3O4@Sr@CA@5-flu) is slower than Fe3O4@Gd@CA@5-flu. The specific absorption rate (SAR) of Fe3O4@Gd@CA@5-flu, 112.0 ± 10.4 W g−1 was found to be higher than that of Fe3O4@Sr@CA@5-flu. The thermogram shows that 11% of the drug was successfully loaded on Fe3O4@Gd@CA@5-flu. The release of the antitumor drug by the synthesized nanoparticle drug carriers for ovarian cancer (SKOV-3 cells) therapy showed that more than 50% of the cancer cell’s viability was reduced after 72 h of incubation. The synthesized nanoparticles demonstrated a promising drug carrier for the treatment of SKOV-3 cells.

Afiliacje autorów:
Olusegun S. - inna afiliacja
Osial M. - IPPT PAN
Majkowska-Pilip A. - inna afiliacja
Żelechowska-Matysiak K. - inna afiliacja
Nieciecka D. - inna afiliacja
Krajewski M. - inna afiliacja
Pękała M. - inna afiliacja
Krysiński P. - inna afiliacja
100p.
5.  Nieciecka D., Celej J., Żuk M.T., Majkowska-Pilip A., Żelechowska-Matysiak K., Lis A., Osial M., Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin, Pharmaceutics, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics13040480, Vol.13, No.4, pp.1-22, 2021

Słowa kluczowe:
SPIONs, doxorubicin, epirubicin, magnetic hyperthermia, cytotoxicity, Langmuir- Blodgett technique

Afiliacje autorów:
Nieciecka D. - inna afiliacja
Celej J. - inna afiliacja
Żuk M.T. - NanoThea Inc. (PL)
Majkowska-Pilip A. - inna afiliacja
Żelechowska-Matysiak K. - inna afiliacja
Lis A. - inna afiliacja
Osial M. - IPPT PAN
100p.

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