Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk

Partnerzy

K. Kucharczyk


Ostatnie publikacje
1.  Kucharczyk K., Rybka J.D., Hilgendorff M., Krupinski M., Slachcinski M., Mackiewicz A., Giersig M., Dams-Kozlowska H., Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications, PLOS ONE, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0219790, Vol.14, No.7, pp. e0219790-1-20, 2019

Streszczenie:
Bioengineered spider silk is a biomaterial that has exquisite mechanical properties, biocompatibility, and biodegradability. Iron oxide nanoparticles can be applied for the detection and analysis of biomolecules, target drug delivery, as MRI contrast agents and as therapeutic agents for hyperthermia-based cancer treatments. In this study, we investigated three bioengineered silks, MS1, MS2 and EMS2, and their potential to form a composite material with magnetic iron oxide nanoparticles (IONPs). The presence of IONPs did not impede the self-assembly properties of MS1, MS2, and EMS2 silks, and spheres formed. The EMS2 spheres had the highest content of IONPs, and the presence of magnetite IONPs in these carriers was confirmed by several methods such as SEM, EDXS, SQUID, MIP-OES and zeta potential measurement. The interaction of EMS2 and IONPs did not modify the superparamagnetic properties of the IONPs, but it influenced the secondary structure of the spheres. The composite particles exhibited a more than two-fold higher loading efficiency for doxorubicin than the plain EMS2 spheres. For both the EMS2 and EMS2/IONP spheres, the drug revealed a pH-dependent release profile with advantageous kinetics for carriers made of the composite material. The composite spheres can be potentially applied for a combined cancer treatment via hyperthermia and drug delivery.

Afiliacje autorów:
Kucharczyk K. - inna afiliacja
Rybka J.D. - inna afiliacja
Hilgendorff M. - inna afiliacja
Krupinski M. - inna afiliacja
Slachcinski M. - inna afiliacja
Mackiewicz A. - inna afiliacja
Giersig M. - inna afiliacja
Dams-Kozlowska H. - inna afiliacja
100p.

Kategoria A Plus

IPPT PAN

logo ippt            ul. Pawińskiego 5B, 02-106 Warszawa
  +48 22 826 12 81 (centrala)
  +48 22 826 98 15
 

Znajdź nas

mapka
© Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk 2024