Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk

Pracownicy

mgr Yasamin Ziai

Zakład Biosystemów i Miękkiej Materii (ZBiMM)
Pracownia Modelowania w Biologii i Medycynie (PMBM)
stanowisko: specjalista
telefon: (+48) 22 826 12 81 wewn.: 330
pokój: 320
e-mail:
ORCID: 0000-0002-0648-761X

Ostatnie publikacje
1.  Pawłowska S., Cysewska K., Ziai Y., Karczewski J., Jasiński P., Molin S., Influence of conductive carbon and MnCo2O4 on morphological and electrical properties of hydrogels for electrochemical energy conversion, Beilstein Journal of Nanotechnology, ISSN: 2190-4286, DOI: 10.3762/bjnano.15.6, pp.57-70, 2024

Słowa kluczowe:
electrical properties, energy, hydrogel, hydrogen, oxygen evolution reaction, polymer composites

Afiliacje autorów:
Pawłowska S. - inna afiliacja
Cysewska K. - inna afiliacja
Ziai Y. - IPPT PAN
Karczewski J. - inna afiliacja
Jasiński P. - inna afiliacja
Molin S. - inna afiliacja
100p.
2.  Ziai Y., Lanzi M., Rinoldi C., Zargarian Seyed S., Zakrzewska A., Kosik-Kozioł A., Nakielski P., Pierini F., Developing strategies to optimize the anchorage between electrospun nanofibers and hydrogels for multi-layered plasmonic biomaterials, Nanoscale Advances, ISSN: 2516-0230, DOI: 10.1039/d3na01022h, pp.1-13, 2024

Streszczenie:
Polycaprolactone (PCL), a recognized biopolymer, has emerged as a prominent choice for diverse biomedical endeavors due to its good mechanical properties, exceptional biocompatibility, and tunable properties. These attributes render PCL a suitable alternative biomaterial to use in biofabrication, especially the electrospinning technique, facilitating the production of nanofibers with varied dimensions and functionalities. However, the inherent hydrophobicity of PCL nanofibers can pose limitations. Conversely, acrylamide-based hydrogels, characterized by their interconnected porosity, significant water retention, and responsive behavior, present an ideal matrix for numerous biomedical applications. By merging these two materials, one can harness their collective strengths while potentially mitigating individual limitations. A robust interface and effective anchorage during the composite fabrication are pivotal for the optimal performance of the nanoplatforms. Nanoplatforms are subject to varying degrees of tension and physical alterations depending on their specific applications. This is particularly pertinent in the case of layered nanostructures, which require careful consideration to maintain structural stability and functional integrity in their intended applications. In this study, we delve into the influence of the fiber dimensions, orientation and surface modifications of the nanofibrous layer and the hydrogel layer's crosslinking density on their intralayer interface to determine the optimal approach. Comprehensive mechanical pull-out tests offer insights into the interfacial adhesion and anchorage between the layers. Notably, plasma treatment of the hydrophobic nanofibers and the stiffness of the hydrogel layer significantly enhance the mechanical effort required for fiber extraction from the hydrogels, indicating improved anchorage. Furthermore, biocompatibility assessments confirm the potential biomedical applications of the proposed nanoplatforms.

Afiliacje autorów:
Ziai Y. - IPPT PAN
Lanzi M. - University of Bologna (IT)
Rinoldi C. - IPPT PAN
Zargarian Seyed S. - IPPT PAN
Zakrzewska A. - IPPT PAN
Kosik-Kozioł A. - IPPT PAN
Nakielski P. - IPPT PAN
Pierini F. - IPPT PAN
20p.
3.  Rinoldi C., Ziai Y., Zargarian Seyed S., Nakielski P., Zembrzycki K., Haghighat Bayan Mohammad A., Zakrzewska A., Fiorelli R., Lanzi M., Kostrzewska-Księżyk A., Czajkowski R., Kublik E., Kaczmarek L., Pierini F., In Vivo Chronic Brain Cortex Signal Recording Based on a Soft Conductive Hydrogel Biointerface, ACS Applied Materials and Interfaces, ISSN: 1944-8244, DOI: 10.1021/acsami.2c17025, Vol.15, No.5, pp.6283-6296, 2023

Streszczenie:
In neuroscience, the acquisition of neural signals from the brain cortex is crucial to analyze brain processes, detect neurological disorders, and offer therapeutic brain–computer interfaces. The design of neural interfaces conformable to the brain tissue is one of today’s major challenges since the insufficient biocompatibility of those systems provokes a fibrotic encapsulation response, leading to an inaccurate signal recording and tissue damage precluding long-term/permanent implants. The design and production of a novel soft neural biointerface made of polyacrylamide hydrogels loaded with plasmonic silver nanocubes are reported herein. Hydrogels are surrounded by a silicon-based template as a supporting element for guaranteeing an intimate neural-hydrogel contact while making possible stable recordings from specific sites in the brain cortex. The nanostructured hydrogels show superior electroconductivity while mimicking the mechanical characteristics of the brain tissue. Furthermore, in vitro biological tests performed by culturing neural progenitor cells demonstrate the biocompatibility of hydrogels along with neuronal differentiation. In vivo chronic neuroinflammation tests on a mouse model show no adverse immune response toward the nanostructured hydrogel-based neural interface. Additionally, electrocorticography acquisitions indicate that the proposed platform permits long-term efficient recordings of neural signals, revealing the suitability of the system as a chronic neural biointerface.

Słowa kluczowe:
brain−machine interface,conductive hydrogels,nanostructured biomaterials,in vitro and in vivo biocompatibility,long-term neural recording

Afiliacje autorów:
Rinoldi C. - IPPT PAN
Ziai Y. - IPPT PAN
Zargarian Seyed S. - IPPT PAN
Nakielski P. - IPPT PAN
Zembrzycki K. - IPPT PAN
Haghighat Bayan Mohammad A. - IPPT PAN
Zakrzewska A. - IPPT PAN
Fiorelli R. - IPPT PAN
Lanzi M. - University of Bologna (IT)
Kostrzewska-Księżyk A. - inna afiliacja
Czajkowski R. - inna afiliacja
Kublik E. - inna afiliacja
Kaczmarek L. - inna afiliacja
Pierini F. - IPPT PAN
200p.
4.  Ziai Y., Zargarian Seyed S., Rinoldi C., Nakielski P., Sola A., Lanzi M., Truong Yen B., Pierini F., Conducting polymer-based nanostructured materials for brain–machine interfaces, WIREs Nanomedicine and Nanobiotechnology, ISSN: 1939-0041, DOI: 10.1002/wnan.1895, Vol.15, No.5, pp.e1895-1-33, 2023

Streszczenie:
As scientists discovered that raw neurological signals could translate into bioelectric information, brain–machine interfaces (BMI) for experimental and clinical studies have experienced massive growth. Developing suitable materials for bioelectronic devices to be used for real-time recording and data digitalizing has three important necessitates which should be covered. Biocompatibility, electrical conductivity, and having mechanical properties similar to soft brain tissue to decrease mechanical mismatch should be adopted for all materials. In this review, inorganic nanoparticles and intrinsically conducting polymers are discussed to impart electrical conductivity to systems, where soft materials such as hydrogels can offer reliable mechanical properties and a biocompatible substrate. Interpenetrating hydrogel networks offer more mechanical stability and provide a path for incorporating polymers with desired properties into one strong network. Promising fabrication methods, like electrospinning and additive manufacturing, allow scientists to customize designs for each application and reach the maximum potential for the system. In the near future, it is desired to fabricate biohybrid conducting polymer-based interfaces loaded with cells, giving the opportunity for simultaneous stimulation and regeneration. Developing multi-modal BMIs, Using artificial intelligence and machine learning to design advanced materials are among the future goals for this field.

Słowa kluczowe:
3D printing,brain–machine interface,conductive hydrogels,electrospinning,neural recording

Afiliacje autorów:
Ziai Y. - IPPT PAN
Zargarian Seyed S. - IPPT PAN
Rinoldi C. - IPPT PAN
Nakielski P. - IPPT PAN
Sola A. - inna afiliacja
Lanzi M. - University of Bologna (IT)
Truong Yen B. - inna afiliacja
Pierini F. - IPPT PAN
140p.
5.  Jain A., Ziai Y., Bochenek K., Manippady Sai R., Pierini F., Michalska M., Utilization of compressible hydrogels as electrolyte materials for supercapacitor applications, RSC Advances, ISSN: 2046-2069, DOI: 10.1039/d3ra00893b, Vol.13, pp.11503-11512, 2023

Streszczenie:
Utilization of CoO@Co3O4-x-Ag (x denotes 1, 3, and 5 wt% of Ag) nanocomposites as supercapacitor electrodes is the main aim of this study. A new low-temperature wet chemical approach is proposed to modify the commercial cobalt oxide material with silver nanoparticle (NP) balls of size 1–5 nm. The structure and morphology of the as-prepared nanocomposites were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and N2 adsorption–desorption measurements. Hydrogels known to be soft but stable structures were used here as perfect carriers for conductive nanoparticles such as carbons. Furthermore, hydrogels with a large amount of water in their network can give more flexibility to the system. Fabrication of an electrochemical cell can be achieved by combining these materials with a layer-by-layer structure. The performance characteristics of the cells were examined by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and galvanostatic charge discharge (GCD). Cobalt oxide modified with 5 wt% Ag gave the best supercapacitor results, and the cell offers a specific capacitance of ∼38 mF cm−2 in two-electrode configurations.

Afiliacje autorów:
Jain A. - IPPT PAN
Ziai Y. - IPPT PAN
Bochenek K. - IPPT PAN
Manippady Sai R. - IPPT PAN
Pierini F. - IPPT PAN
Michalska M. - Łukasiewicz Research Network‒Institute of Electronic Materials Technology (PL)
100p.
6.  Nakielski P., Rinoldi C., Pruchniewski M., Pawłowska S., Gazińska M., Strojny B., Rybak D., Jezierska-Woźniak K., Urbanek O., Denis P., Sinderewicz E., Czelejewska W., Staszkiewicz-Chodor J., Grodzik M., Ziai Y., Barczewska M., Maksymowicz W., Pierini F., Laser-assisted fabrication of injectable nanofibrous cell carriers, Small, ISSN: 1613-6810, DOI: 10.1002/smll.202104971, Vol.18, No.2, pp.2104971-1-18, 2022

Streszczenie:
The use of injectable biomaterials for cell delivery is a rapidly expanding field which may revolutionize the medical treatments by making them less invasive. However, creating desirable cell carriers poses significant challenges to the clinical implementation of cell-based therapeutics. At the same time, no method has been developed to produce injectable microscaffolds (MSs) from electrospun materials. Here the fabrication of injectable electrospun nanofibers is reported on, which retain their fibrous structure to mimic the extracellular matrix. The laser-assisted micro-scaffold fabrication has produced tens of thousands of MSs in a short time. An efficient attachment of cells to the surface and their proliferation is observed, creating cell-populated MSs. The cytocompatibility assays proved their biocompatibility, safety, and potential as cell carriers. Ex vivo results with the use of bone and cartilage tissues proved that NaOH hydrolyzed and chitosan functionalized MSs are compatible with living tissues and readily populated with cells. Injectability studies of MSs showed a high injectability rate, while at the same time, the force needed to eject the load is no higher than 25 N. In the future, the produced MSs may be studied more in-depth as cell carriers in minimally invasive cell therapies and 3D bioprinting applications.

Afiliacje autorów:
Nakielski P. - IPPT PAN
Rinoldi C. - IPPT PAN
Pruchniewski M. - inna afiliacja
Pawłowska S. - IPPT PAN
Gazińska M. - inna afiliacja
Strojny B. - inna afiliacja
Rybak D. - IPPT PAN
Jezierska-Woźniak K. - inna afiliacja
Urbanek O. - IPPT PAN
Denis P. - IPPT PAN
Sinderewicz E. - inna afiliacja
Czelejewska W. - inna afiliacja
Staszkiewicz-Chodor J. - inna afiliacja
Grodzik M. - inna afiliacja
Ziai Y. - IPPT PAN
Barczewska M. - University of Warmia and Mazury in Olsztyn (PL)
Maksymowicz W. - University of Warmia and Mazury in Olsztyn (PL)
Pierini F. - IPPT PAN
200p.
7.  Ziai Y., Petronella F., Rinoldi C., Nakielski P., Zakrzewska A., Kowalewski T.A., Augustyniak W., Li X., Calogero A., Sabała I., Ding B., De Sio L., Pierini F., Chameleon-inspired multifunctional plasmonic nanoplatforms for biosensing applications, NPG Asia Materials, ISSN: 1884-4049, DOI: 10.1038/s41427-022-00365-9, Vol.14, pp.18-1-17, 2022

Streszczenie:
One of the most fascinating areas in the field of smart biopolymers is biomolecule sensing. Accordingly, multifunctional biomimetic, biocompatible, and stimuli-responsive materials based on hydrogels have attracted much interest. Within this framework, the design of nanostructured materials that do not require any external energy source is beneficial for developing a platform for sensing glucose in body fluids. In this article, we report the realization and application of an innovative platform consisting of two outer layers of a nanocomposite plasmonic hydrogel plus one inner layer of electrospun mat fabricated by electrospinning, where the outer layers exploit photoinitiated free radical polymerization, obtaining a compact and stable device. Inspired by the exceptional features of chameleon skin, plasmonic silver nanocubes are embedded into a poly(N-isopropylacrylamide)-based hydrogel network to obtain enhanced thermoresponsive and antibacterial properties. The introduction of an electrospun mat creates a compatible environment for the homogeneous hydrogel coating while imparting excellent mechanical and structural properties to the final system. Chemical, morphological, and optical characterizations were performed to investigate the structure of the layers and the multifunctional platform. The synergetic effect of the nanostructured system’s photothermal responsivity and antibacterial properties was evaluated. The sensing features associated with the optical properties of silver nanocubes revealed that the proposed multifunctional system is a promising candidate for glucose-sensing applications.

Afiliacje autorów:
Ziai Y. - IPPT PAN
Petronella F. - inna afiliacja
Rinoldi C. - IPPT PAN
Nakielski P. - IPPT PAN
Zakrzewska A. - IPPT PAN
Kowalewski T.A. - IPPT PAN
Augustyniak W. - Mossakowski Medical Research Centre, Polish Academy of Sciences (PL)
Li X. - Donghua University (CN)
Calogero A. - Sapienza University of Rome (IT)
Sabała I. - Mossakowski Medical Research Centre, Polish Academy of Sciences (PL)
Ding B. - Donghua University (CN)
De Sio L. - Sapienza University of Rome (IT)
Pierini F. - IPPT PAN
140p.
8.  Marinelli M., Lanzi M., Pierini F., Ziai Y., Zanelli A., Quadretti D., Di Maria F., Salatelli E., Ionic Push–Pull Polythiophenes: A Further Step towards Eco-Friendly BHJ Organic Solar Cells, Polymers, ISSN: 2073-4360, DOI: 10.3390/polym14193965, Vol.14, No.19, pp.3965-1-17, 2022

Streszczenie:
Four new conjugated polymers alternating benzothiadiazole units and thiophene moieties functionalized with ionic phosphonium or sulfonic acid salts in the side chains were synthesized by a postfunctionalization approach of polymeric precursors. The introduction of ionic groups makes the conjugated polymers soluble in water and/or polar solvents, allowing for the fabrication of bulk heterojunction (BHJ) solar cells using environmentally friendly conditions. All polymers were fully characterized by spectroscopic, thermal, electrochemical, X-ray diffraction, scanning electron, and atomic force techniques. BHJ solar cells were obtained from halogen-free solvents (i.e., ethanol and/or anisole) by blending the synthesized ionic push–pull polymers with a serinol-fullerene derivative or an ionic homopolymer acting as electron-acceptor (EA) or electron-donor (ED) counterparts, respectively. The device with the highest optical density and the smoothest surface of the active layer was the best-performing, showing a 4.76% photoconversion efficiency.

Słowa kluczowe:
donor–acceptor systems, bifunctional materials, phosphonium salts, eco-friendly BHJ solar cells, anisole

Afiliacje autorów:
Marinelli M. - inna afiliacja
Lanzi M. - University of Bologna (IT)
Pierini F. - IPPT PAN
Ziai Y. - IPPT PAN
Zanelli A. - CNR-ISOF (IT)
Quadretti D. - University of Bologna (IT)
Di Maria F. - CNR-ISOF (IT)
Salatelli E. - University of Bologna (IT)
100p.
9.  Ziai Y., Rinoldi C., Nakielski P., De Sio L., Pierini F., Smart plasmonic hydrogels based on gold and silver nanoparticles for biosensing application, Current Opinion in Biomedical Engineering, ISSN: 2468-4511, DOI: 10.1016/j.cobme.2022.100413, Vol.24, pp.100413-1-8, 2022

Streszczenie:
The importance of having a fast, accurate, and reusable track for detection has led to an increase investigation in the field of biosensing. Optical biosensing using plasmonic nanoparticles, such as gold and silver, introduces localized surface plasmon resonance (LSPR) sensors. LSPR biosensors are progressive in their sensing precision and detection limit. Also, the possibility to tune the sensing range by varying the size and shape of the particles has made them extremely useful. Hydrogels being hydrophilic 3D networks can be beneficial when used as matrices, because of a more efficient biorecognition. Stimuli-responsive hydrogels can be great candidates, as their response to a stimulus can increase recognition and detection. This article highlights recent advances in combining hydrogels as a matrix and plasmonic nanoparticles as sensing elements. The end capability and diversity of these novel biosensors in different applications in the near future are discussed.

Słowa kluczowe:
Smart materials, Plasmonic hydrogel, Biosensing

Afiliacje autorów:
Ziai Y. - IPPT PAN
Rinoldi C. - IPPT PAN
Nakielski P. - IPPT PAN
De Sio L. - Sapienza University of Rome (IT)
Pierini F. - IPPT PAN
20p.
10.  Lanzi M., Quadretti D., Marinelli M., Ziai Y., Salatelli E., Pierini F., Influence of the active layer structure on the photovoltaic performance of water-soluble polythiophene-based solar cells, Polymers, ISSN: 2073-4360, DOI: 10.3390/polym13101640, Vol.13, No.10, pp.1640-1-20, 2021

Streszczenie:
A new side-chain C60-fullerene functionalized thiophene copolymer bearing tributylphosphine-substituted hexylic lateral groups was successfully synthesized by means of a fast and effective post-polymerization reaction on a regioregular ω-alkylbrominated polymeric precursor. The growth of the polymeric intermediate was followed by NMR spectrometry in order to determine the most convenient reaction time. The obtained copolymer was soluble in water and polar solvents and was used as a photoactive layer in single-material organic photovoltaic (OPV) solar cells. The copolymer photovoltaic efficiency was compared with that of an OPV cell containing a water-soluble polythiophenic homopolymer, functionalized with the same tributylphosphine-substituted hexylic side chains, in a blend with a water-soluble C60-fullerene derivative. The use of a water-soluble double-cable copolymer made it possible to enhance the control on the nanomorphology of the active blend, thus reducing phase-segregation phenomena, as well as the macroscale separation between the electron acceptor and donor components. Indeed, the power conversion efficiency of OPV cells based on a single material was higher than that obtained with the classical architecture, involving the presence of two distinct ED and EA materials (PCE: 3.11% vs. 2.29%, respectively). Moreover, the synthetic procedure adopted to obtain single material-based cells is more straightforward and easier than that used for the preparation of the homopolymer-based BHJ solar cell, thus making it possible to completely avoid the long synthetic pathway which is required to prepare water-soluble fullerene derivatives.

Słowa kluczowe:
water-soluble polymers, double-cable copolymers, polythiophenes, GRIM polymerization, tributylphosphine, water-soluble fullerenes, OPVs

Afiliacje autorów:
Lanzi M. - University of Bologna (IT)
Quadretti D. - University of Bologna (IT)
Marinelli M. - IPPT PAN
Ziai Y. - IPPT PAN
Salatelli E. - University of Bologna (IT)
Pierini F. - IPPT PAN
100p.
11.  Nakielski P., Pawłowska S., Rinoldi C., Ziai Y., De Sio L., Urbanek O., Zembrzycki K., Pruchniewski M., Lanzi M., Salatelli E., Calogero A., Kowalewski T.A., Yarin A.L., Pierini F., Multifunctional platform based on electrospun nanofibers and plasmonic hydrogel: a smart nanostructured pillow for near-Infrared light-driven biomedical applications, ACS Applied Materials and Interfaces, ISSN: 1944-8244, DOI: 10.1021/acsami.0c13266, Vol.12, No.49, pp.54328-54342, 2020

Streszczenie:
Multifunctional nanomaterials with the ability torespond to near-infrared (NIR) light stimulation are vital for thedevelopment of highly efficient biomedical nanoplatforms with apolytherapeutic approach. Inspired by the mesoglea structure ofjellyfish bells, a biomimetic multifunctional nanostructured pillowwith fast photothermal responsiveness for NIR light-controlled on-demand drug delivery is developed. We fabricate a nanoplatformwith several hierarchical levels designed to generate a series ofcontrolled, rapid, and reversible cascade-like structural changesupon NIR light irradiation. The mechanical contraction of thenanostructured platform, resulting from the increase of temper-ature to 42°C due to plasmonic hydrogel−light interaction, causesa rapid expulsion of water from the inner structure, passing through an electrospun membrane anchored onto the hydrogel core. Themutual effects of the rise in temperature and waterflow stimulate the release of molecules from the nanofibers. To expand thepotential applications of the biomimetic platform, the photothermal responsiveness to reach the typical temperature level forperforming photothermal therapy (PTT) is designed. The on-demand drug model penetration into pig tissue demonstrates theefficiency of the nanostructured platform in the rapid and controlled release of molecules, while the high biocompatibility confirmsthe pillow potential for biomedical applications based on the NIR light-driven multitherapy strategy.

Słowa kluczowe:
bioinspired materials, NIR-light responsive nanomaterials, multifunctional platforms, electrospun nanofibers, plasmonic hydrogel, photothermal-based polytherapy, on-demand drug delivery

Afiliacje autorów:
Nakielski P. - IPPT PAN
Pawłowska S. - IPPT PAN
Rinoldi C. - IPPT PAN
Ziai Y. - IPPT PAN
De Sio L. - Sapienza University of Rome (IT)
Urbanek O. - IPPT PAN
Zembrzycki K. - IPPT PAN
Pruchniewski M. - inna afiliacja
Lanzi M. - University of Bologna (IT)
Salatelli E. - University of Bologna (IT)
Calogero A. - Sapienza University of Rome (IT)
Kowalewski T.A. - IPPT PAN
Yarin A.L. - Technion - Israel Institute of Technology (IL)
Pierini F. - IPPT PAN
200p.
12.  Pawłowska S., Rinoldi C., Nakielski P., Ziai Y., Urbanek O., Li X., Kowalewski T.A., Ding B., Pierini F., Ultraviolet light‐assisted electrospinning of core–shell fully cross‐linked P(NIPAAm‐co‐NIPMAAm) hydrogel‐based nanofibers for thermally induced drug delivery self‐regulation, Advanced Materials Interfaces, ISSN: 2196-7350, DOI: 10.1002/admi.202000247, Vol.7, No.12, pp.2000247-1-13, 2020

Streszczenie:
Body tissues and organs have complex functions which undergo intrinsic changes during medical treatments. For the development of ideal drug delivery systems, understanding the biological tissue activities is necessary to be able to design materials capable of changing their properties over time, on the basis of the patient's tissue needs. In this study, a nanofibrous thermal‐responsive drug delivery system is developed. The thermo‐responsivity of the system makes it possible to self‐regulate the release of bioactive molecules, while reducing the drug delivery at early stages, thus avoiding high concentrations of drugs which may be toxic for healthy cells. A co‐axial electrospinning technique is used to fabricate core–shell cross‐linked copolymer poly(N‐isopropylacrylamide‐co‐N‐isopropylmethacrylamide) (P(NIPAAm‐co‐NIPMAAm)) hydrogel‐based nanofibers. The obtained nanofibers are made of a core of thermo‐responsive hydrogel containing a drug model, while the outer shell is made of poly‐l‐lactide‐co‐caprolactone (PLCL). The custom‐made electrospinning apparatus enables the in situ cross‐linking of P(NIPAAm‐co‐NIPMAAm) hydrogel into a nanoscale confined space, which improves the electrospun nanofiber drug dosing process, by reducing its provision and allowing a self‐regulated release control. The mechanism of the temperature‐induced release control is studied in depth, and it is shown that the system is a promising candidate as a "smart" drug delivery platform.

Słowa kluczowe:
biomimetic nanomaterials, electrospun core–shell nanofibers, hierarchical nanostructures, smart drug delivery, thermo‐responsive hydrogels

Afiliacje autorów:
Pawłowska S. - IPPT PAN
Rinoldi C. - IPPT PAN
Nakielski P. - IPPT PAN
Ziai Y. - IPPT PAN
Urbanek O. - IPPT PAN
Li X. - Donghua University (CN)
Kowalewski T.A. - IPPT PAN
Ding B. - Donghua University (CN)
Pierini F. - IPPT PAN
100p.

Lista rozdziałów w ostatnich monografiach
1. 
Petronella F., Stoia D., Ziai Y., Zaccagnini F., Scognamiglio V., Maniu D., Rinoldi C., Focsan M., Antonacci A., Pierini F., De Sio L., Novel Optical Materials, rozdział: Chapter 6: Plasmonic-based Biosensors for the Rapid Detection of Harmful Pathogens, World Scientific, 1, pp.155-194, 2023

Prace konferencyjne
1.  Zargarian S.S., Rinoldi C., Ziai Y., Nakielski P., and Pierini F., DEVELOPMENT OF CONDUCTIVE STIMULI-RESPONSIVE FIBROUS HYDROGELS FOR NEURAL INTERFACES, TERMIS-EU 2022, Tissue Engineering and Regenerative Medicine International Society European Chapter Conference 2022, 2022-06-28/07-01, Kraków (PL), No.2022, pp.2, 2022

Abstrakty konferencyjne
1.  Ziai Y., Petronella F., Rinoldi C., Nakielski P., De Sio L., Pierini F., An AgNPs-incorporated hydrogel-based nanocomposite for lysozyme biosensing, NANOMAT2023, 6th International Conference on Functional Nanomaterials and Nanodevices, 2023-08-27/08-30, Warsaw (PL), No.075, pp.109, 2023

Streszczenie:
Lysozyme, an enzyme found in various bodily fluids, holds immense importance as a biomolecule with numerous diagnostic implications. In the realm of ophthalmology, lysozyme detection in tears emerges as a precious tool for identifying and addressing dry and inflamed eyes. To enhance the precision and efficiency of lysozyme detection, Smart materials, such as hydrogels and electrospun nanofibers, have been confirmed to be promising candidates for sensing platforms. Plasmonic nanoparticles, on the other hand, offer enhanced optical properties that allow for localized surface plasmon resonance (LSPR), which has been used alongside these substrates. By integrating these smart materials into biosensing platforms, researchers can achieve rapid, reliable, and non-invasive lysozyme detection from tears.
To achieve this goal, a layered platform consisting of a hydrogel layer, electrospun nanofibers, and plasmonic nanoparticles was designed and fabricated. Electrospun mat of poly (L-lactide-co-caprolactone) (PLCL) was used as the support, providing suitable mechanical properties to the platform. Silver nanoplates were immobilized on top of the electrospun nanofibers, where a layer of poly(N-isopropylacrylamide)-based hydrogel was added. With its porous 3D structure and high water content, the hydrogel network allows enhancement in photothermal responsivity. Moreover, due to its fluid nature, the maneuvering of the biomolecules is much easier, making the biosensing procedure more accurate. The structure of each layer, their cross-section, and the whole platform were investigated chemically, morphologically, and optically. The fast photothermal responsitivity of the platform and sensing features were studied, revealing the applicability of the system as a biosensor for detecting lysozyme.

Afiliacje autorów:
Ziai Y. - IPPT PAN
Petronella F. - inna afiliacja
Rinoldi C. - IPPT PAN
Nakielski P. - IPPT PAN
De Sio L. - Sapienza University of Rome (IT)
Pierini F. - IPPT PAN
2.  Zargarian S.S., Rinoldi C., Ziai Y., Nakielski P., Pierini F., Synthesis and Fabrication of Thermoresponsive Cross-linkable Poly(N-Isopropylacrylamide-Co-Glycidyl Methacrylate), Chemeet, International Chemistry Conference, 2022-06-27/06-29, Madrid, Spain. Hybrid Conference (ES), No.2022, pp.3-4, 2022

Streszczenie:
Due to their importance in various fields of bio-nanotechnology, the synthesis of thermoresponsive smart polymers has been the focus of recent research. Poly(N-isopropylacrylamide) (PNIPAAm) is a well-known thermal-stimulus responsive polymer that has attracted much attention. For PNIPAAm hydrogels to acquire fast thermo-responsive properties, water molecules must have quick access to the entire material. However, isotropic PNIPAAm-based hydrogels have a slow stimulus-responsivity. Hydrophilic cross-linkable nanostructures are gaining interest as a viable alternative to traditional hydrogels to address this issue. System miniaturization via electrospinning exhibits nanostructures with significantly larger porosity and specific surface area. If the constituting hydrophilic polymer of the electrospun fibrous material were cross-linkable, the resulting would display a rapid hydration/dehydration response. As a result, developing a new class of cross-linkable PNIPAAm copolymers is highly desired.

Afiliacje autorów:
Zargarian S.S. - IPPT PAN
Rinoldi C. - IPPT PAN
Ziai Y. - IPPT PAN
Nakielski P. - IPPT PAN
Pierini F. - IPPT PAN
3.  Ziai Y., Rinoldi C., Nakielski P., Kowalewski T.A., Pierini F., Chameleon-inspired multifunctional plasmonic nanoplatforms for biosensing applications, TERMIS EU 2022, 2022-06-28/07-01, Krakow (PL), No.PS16.11, pp.1, 2022
4.  Zargarian S.S., Rinoldi C., Ziai Y., Nakielski P., and Pierini F., Development of Conductive Fibrous Hydrogels for Neural Interfaces, 4th INTERDISCIPLINARY FNP CONFERENCE, 2022-10-06/10-07, Warsaw (PL), No.2022, pp.8, 2022
5.  Rinoldi C., Ziai Y., Zembrzycki K., Pierini F., CONDUCTIVE HYDROGEL NANOCOMPOSITE-BASED NEURAL INTERFACE FOR IN VIVO RECORDING OF BRAIN CORTEX SIGNALS, TERMIS-EU 2022, Tissue Engineering and Regenerative Medicine International Society European Chapter Conference 2022, 2022-06-28/07-01, Kraków (PL), No.262, pp.1, 2022
6.  Nabavian-Kalat M., Staszczak M., Ziai Y., Urbański L., Pieczyska E., Effect of Shape Recovery and Cyclic Loading on the Evolution of Micro-Cracks in Shape Memory Polymers, IUTAM Symposium, IUTAM Symposium on Enhancing Material Performance by Exploiting Instabilities and Damage Evolution, 2022-06-05/06-10, Warszawa (PL), DOI: 10.24423/iutam2022warsaw, No.P040, pp.54-54, 2022
7.  Nabavian Kalat M., Staszczak M., Ziai Y., Gradys A., Urbański L., Pieczyska E.A., THE EFFECT OF SHAPE MEMORY BEHAVIOR ON THE MICROSTRUCTURE OF THE PU-SMP (Tg = 45°C), ICEM, 19th International Conference on Experimental Mechanics, 2022-07-17/07-21, Kraków (PL), pp.278-279, 2022
8.  Ziai Y., Rinoldi C., Pawłowska S., Nakielski P., Kowalewski T.A., Pierini F., DESIGN AND CHARACTERIZATION OF PHOTORESPONSIVE MULTIFUNCTIONAL HYDROGEL-BASED COMPOSITE PLATFORM, TERMIS 6th World Congress, Tissue Engineering and Regenerative Medicine International Society 6th World Congress 2021, 2021-11-15/11-19, Maastricht (NL), No.506, pp.430, 2021
9.  Rinoldi C., Pawłowska S., Nakielski P., Ziai Y., Urbanek O., Kowalewski T.A., Pierini F., LIGHT-ASSISTED ELECTROSPINNING OF CORE-SHELL P(NIPAAM-CO-NIPMAAM) HYDROGEL-BASED NANOFIBERS FOR THERMALLY SELF-REGULATED DRUG DELIVERY, TERMIS 6th World Congress, Tissue Engineering and Regenerative Medicine International Society 6th World Congress 2021, 2021-11-15/11-19, Maastricht (NL), No.286, pp.246, 2021
10.  Zargarian S., Rinoldi C., Ziai Y., Nakielski P., Pierini F., Fabrication of poly (N-isopropylacrylamide-co-glycidyl methacrylate) electrospun hydrogel fibers, NanoInnovation 2021 Conference, 2021-09-21/09-24, Rome (IT), pp.89, 2021
11.  Rinoldi C., Pawłowska S., Nakielski P., Ziai Y., Urbanek O., Kowalewski T.A., Pierini F., Electrospinning of core-shell cross-linked P(NIPAAm-co-NIPMAAm) for tissue engineering, WBC2020, 11th World Biomaterials Congress, 2020-12-11/12-15, online (GB), No.4190, pp.1, 2020
12.  Pierini F., Nakielski P., Pawłowska S., Rinoldi C., Ziai Y., Urbanek-Świderska O., De Sio L., Calogero A., Lanzi M., Zembrzycki K., Pruchniewski M., Salatelli E., Kowalewski T.A., Yarin A., Nature-inspired smart drug delivery platforms based on electrospun nanofibers and plasmonic hydrogels for near-infrared light-controlled polytherapy, Polymer Connect, Polymer Science and Composite Materials Conference, 2020-02-26/02-28, LISBON (PT), pp.7, 2020

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2023-09-25
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Pierini F., Zargarian S., Rinoldi C., Ziai Y., Nakielski P.
Przewodzące nanowłókna hydrożelowe o współ przenikającej sieci (semi-IPN) do pokrywania sond neuronowych oraz sposób ich wytwarzania
PL, Instytut Podstawowych Problemów Techniki PAN
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