Institute of Fundamental Technological Research
Polish Academy of Sciences

Partners

Xiaoran Li

Donghua University (CN)

Recent publications
1.  Pawłowska S., Rinoldi C., Nakielski P., Ziai Y., Urbanek O., Li X., Kowalewski T.A., Ding B., Pierini F., Ultraviolet light‐assisted electrospinning of core–shell fully cross‐linked P(NIPAAm‐co‐NIPMAAm) hydrogel‐based nanofibers for thermally induced drug delivery self‐regulation, Advanced Materials Interfaces, ISSN: 2196-7350, DOI: 10.1002/admi.202000247, Vol.7, No.12, pp.2000247-1-13, 2020

Abstract:
Body tissues and organs have complex functions which undergo intrinsic changes during medical treatments. For the development of ideal drug delivery systems, understanding the biological tissue activities is necessary to be able to design materials capable of changing their properties over time, on the basis of the patient's tissue needs. In this study, a nanofibrous thermal‐responsive drug delivery system is developed. The thermo‐responsivity of the system makes it possible to self‐regulate the release of bioactive molecules, while reducing the drug delivery at early stages, thus avoiding high concentrations of drugs which may be toxic for healthy cells. A co‐axial electrospinning technique is used to fabricate core–shell cross‐linked copolymer poly(N‐isopropylacrylamide‐co‐N‐isopropylmethacrylamide) (P(NIPAAm‐co‐NIPMAAm)) hydrogel‐based nanofibers. The obtained nanofibers are made of a core of thermo‐responsive hydrogel containing a drug model, while the outer shell is made of poly‐l‐lactide‐co‐caprolactone (PLCL). The custom‐made electrospinning apparatus enables the in situ cross‐linking of P(NIPAAm‐co‐NIPMAAm) hydrogel into a nanoscale confined space, which improves the electrospun nanofiber drug dosing process, by reducing its provision and allowing a self‐regulated release control. The mechanism of the temperature‐induced release control is studied in depth, and it is shown that the system is a promising candidate as a "smart" drug delivery platform.

Keywords:
biomimetic nanomaterials, electrospun core–shell nanofibers, hierarchical nanostructures, smart drug delivery, thermo‐responsive hydrogels

Affiliations:
Pawłowska S. - IPPT PAN
Rinoldi C. - IPPT PAN
Nakielski P. - IPPT PAN
Ziai Y. - IPPT PAN
Urbanek O. - IPPT PAN
Li X. - Donghua University (CN)
Kowalewski T.A. - IPPT PAN
Ding B. - Donghua University (CN)
Pierini F. - IPPT PAN
2.  Wang L., Lv H., Liu L., Zhang Q., Nakielski P., Si Y., Cao J., Li X., Pierini F., Yu J., Ding B., Electrospun nanofiber-reinforced three-dimensional chitosan matrices: architectural, mechanical and biological properties, JOURNAL OF COLLOID AND INTERFACE SCIENCE, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2020.01.016, Vol.565, pp.416-425, 2020

Abstract:
The poor intrinsic mechanical properties of chitosan hydrogels have greatly hindered their practical applications. Inspired by nature, we proposed a strategy to enhance the mechanical properties of chitosan hydrogels by construction of a nanofibrous and cellular architecture in the hydrogel without toxic chemical crosslinking. To this end, electrospun nanofibers including cellulose acetate, polyacrylonitrile, and SiO2 nanofibers were introduced into chitosan hydrogels by homogenous dispersion and lyophilization. With the addition of 30% cellulose acetate nanofibers, the cellular structure could be maintained even in water without crosslinking, and integration of 60% of the nanofibers could guarantee the free-standing structure of the chitosan hydrogel with a low solid content of 1%. Moreover, the SiO2 nanofiber-reinforced chitosan (SiO2 NF/CS) three-dimensional (3D) matrices exhibit complete shape recovery from 80% compressive strain and excellent injectability. The cellular architecture and nanofibrous structure in the SiO2 NF/CS matrices are beneficial for human mesenchymal stem cell adhesion and stretching. Furthermore, the SiO2 NF/CS matrices can also act as powerful vehicles for drug delivery. As an example, bone morphogenetic protein 2 could be immobilized on SiO2 NF/CS matrices to induce osteogenic differentiation. Together, the electrospun nanofiber-reinforced 3D chitosan matrices exhibited improved mechanical properties and enhanced biofunctionality, showing great potential in tissue engineering.

Keywords:
chitosan hydrogel, electrospun nanofiber, mechanical property, nanofibrous matrix, tissue engineering

Affiliations:
Wang L. - Imperial College London (GB)
Lv H. - Medical College of Soochow University (CN)
Liu L. - Donghua University (CN)
Zhang Q. - Medical College of Soochow University (CN)
Nakielski P. - IPPT PAN
Si Y. - Donghua University (CN)
Cao J. - other affiliation
Li X. - Donghua University (CN)
Pierini F. - IPPT PAN
Yu J. - Donghua University (CN)
Ding B. - Donghua University (CN)

Patents
Filing No./Date
Filing Publication
Autors
Title
Protection Area, Applicant Name
Patent Number
Date of Grant
pdf
435749
2020-10-21
-
-
Pierini F., Nakielski P., Rinoldi C., Pawłowska S., Ding B., Li X., Si Y.
Nanoplatforma dostarczania leków na żądanie, sposób jej wytwarzania oraz zastosowanie
PL, Instytut Podstawowych Problemów Techniki PAN
-
-
-

Category A Plus

IPPT PAN

logo ippt            Pawińskiego 5B, 02-106 Warsaw
  +48 22 826 12 81 (central)
  +48 22 826 98 15
 

Find Us

mapka
© Institute of Fundamental Technological Research Polish Academy of Sciences 2021