Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk


Agnieszka Ostrowska

Ostatnie publikacje
1.  Pruchniewski M., Sawosz E., Sosnowska-Ławnicka M., Ostrowska A., Łojkowski M., Koczoń P., Nakielski P., Kutwin M., Jaworski S., Strojny-Cieślak B., Nanostructured graphene oxide enriched with metallic nanoparticles as a biointerface to enhance cell adhesion through mechanosensory modifications, NANOSCALE, ISSN: 2040-3364, DOI: 10.1039/d3nr03581f, Vol.15, No.46, pp.18639-18659, 2023

Nanostructuring is a process involving surface manipulation at the nanometric level, which improves the mechanical and biological properties of biomaterials. Specifically, it affects the mechanotransductive perception of the microenvironment of cells. Mechanical force conversion into an electrical or chemical signal contributes to the induction of a specific cellular response. The relationship between the cells and growth surface induces a biointerface-modifying cytophysiology and consequently a therapeutic effect. In this study, we present the fabrication of graphene oxide (GO)-based nanofilms decorated with metallic nanoparticles (NPs) as potential coatings for biomaterials. Our investigation showed the effect of decorating GO with metallic NPs for the modification of the physicochemical properties of nanostructures in the form of nanoflakes and nanofilms. A comprehensive biocompatibility screening panel revealed no disturbance in the metabolic activity of human fibroblasts (HFFF2) and bone marrow stroma cells (HS-5) cultivated on the GO nanofilms decorated with gold and copper NPs, whereas a significant cytotoxic effect of the GO nanocomplex decorated with silver NPs was demonstrated. The GO nanofilm decorated with gold NPs beneficially managed early cell adhesion as a result of the transient upregulation of α1β5 integrin expression, acceleration of cellspreading, and formation of elongated filopodia. Additionally, the cells, sensing the substrate derived from the nanocomplex enriched with gold NPs, showed reduced elasticity and altered levels of vimentin expression. In the future, GO nanocomplexes decorated with gold NPs can be incorporated in the structure of architecturally designed biomimetic biomaterials as biocompatible nanostructuring agents with proadhesive properties.

Afiliacje autorów:
Pruchniewski M. - inna afiliacja
Sawosz E. - Warsaw University of Life Sciences (PL)
Sosnowska-Ławnicka M. - inna afiliacja
Ostrowska A. - inna afiliacja
Łojkowski M. - inna afiliacja
Koczoń P. - inna afiliacja
Nakielski P. - IPPT PAN
Kutwin M. - Warsaw University of Life Sciences (PL)
Jaworski S. - Warsaw University of Life Sciences (PL)
Strojny-Cieślak B. - inna afiliacja

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