Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk


Amirhosein Kefayat

Isfahan University of Medical Sciences (IR)

Ostatnie publikacje
1.  Pahlevanneshan Z., Deypour M., Kefayat A., Rafienia M., Sajkiewicz P., Neisiany R.E., Enayati M., Polyurethane-nanolignin composite foam coated with propolis as a platform for wound dressing: synthesis and characterization, Polymers, ISSN: 2073-4360, DOI: 10.3390/polym13183191, Vol.13, No.18, pp.3191-1-15, 2021

This piece of research explores porous nanocomposite polyurethane (PU) foam synthesis, containing nanolignin (NL), coated with natural antimicrobial propolis for wound dressing. PU foam was synthesized using polyethylene glycol, glycerol, NL, and 1, 6-diisocyanato-hexane (NCO/OH ratio: 1.2) and water as blowing agent. The resultant foam was immersed in ethanolic extract of propolis (EEP). PU, NL-PU, and PU-NL/EEP foams were characterized from mechanical, morphological, and chemical perspectives. NL Incorporation into PU increased mechanical strength, while EEP coating showed lower strength than PU-NL/EEP. Morphological investigations confirmed an open-celled structure with a pore diameter of 150–200 μm, a density of nearly 0.2 g/cm3,, and porosity greater than 85%, which led to significantly high water absorption (267% for PU-NL/EEP). The hydrophilic nature of foams, measured by the contact angle, proved to be increased by NL addition and EEP coating. PU and PU-NL did not show important antibacterial features, while EEP coating resulted in a significant antibacterial efficiency. All foams revealed high biocompatibility toward L929 fibroblasts, with the highest cell viability and cell attachment for PU-NL/EEP. In vivo wound healing using Wistar rats’ full-thickness skin wound model confirmed that PU-NL/EEP exhibited an essentially higher wound healing efficacy compared with other foams. Hence, PU-NL/EEP foam could be a promising wound dressing candidate.

Słowa kluczowe:
polyurethane foam, nanolignin, propolis, wound dressing

Afiliacje autorów:
Pahlevanneshan Z. - Payame Noor University (IR)
Deypour M. - Isfahan University of Medical Sciences (IR)
Kefayat A. - Isfahan University of Medical Sciences (IR)
Rafienia M. - Isfahan University of Medical Sciences (IR)
Sajkiewicz P. - IPPT PAN
Neisiany R.E. - Isfahan University of Technology (IR)
Enayati M. - Isfahan University of Technology (IR)

Kategoria A Plus


logo ippt            ul. Pawińskiego 5B, 02-106 Warszawa
  +48 22 826 12 81 (centrala)
  +48 22 826 98 15

Znajdź nas

© Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk 2024