Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk

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Asmaa Ahmed Arafa


Ostatnie publikacje
1.  Arafa A.A., Nada A.A., Ibrahim A.Y., Sajkiewicz P., Zahran M.K., Hakeim O.A., Preparation and characterization of smart therapeutic pH-sensitive wound dressing from red cabbage extract and chitosan hydrogel, International Journal of Biological Macromolecules, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2021.05.167, Vol.182, pp.1820-1831, 2021

Streszczenie:
Developing a multifunctional wound dressing that protects, cures and indicates the healing progress, is a new approach of investigation. Red cabbage extract (RCE), consisting of bioactive compounds that have antioxidant, anti-inflammatory, anti-carcinogenic, bactericidal, antifungal, and antiviral activities, was utilized as a natural pH-sensitive indicator. Chitosan-based hydrogel, encapsulating RCE, was developed to obtain a smart therapeutic pH-sensitive wound dressing as antimicrobial bio-matrix provides a comfortable cushion for wound bed and indicates its status. Methacrylated-chitosan was crosslinked by different concentrations of methylenebisacrylamide (MBAA) by which hydrogel mechanical and morphological properties were tuned. The proposed mechanism for hydrogel formation was confirmed by FT-IR. The coloristic properties of the RCE and the changes in color intensity as a function of pH were confirmed by UV–Vis spectroscopy. The effect of MBAA on the mechanical, swelling, release and morphological properties of hydrogel were investigated. MBAA (2.5% wt/v) in 2% wt/v chitosan showed preferable mechanical (20 KPa), swelling (1294% at pH 8 ± 0.2), and release (prolonged up to 5 days) properties. Hydrogel matrices, loaded on cotton gauze submerged in different pH buffer solutions, showed explicit color changes from green to red as pH changed from 9 to 4.

Słowa kluczowe:
pH-sensitive dye, wound dressing, N-methacylated chitosan

Afiliacje autorów:
Arafa A.A. - inna afiliacja
Nada A.A. - inna afiliacja
Ibrahim A.Y. - inna afiliacja
Sajkiewicz P. - IPPT PAN
Zahran M.K. - inna afiliacja
Hakeim O.A. - inna afiliacja
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