Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk


Asmaa Ahmed Arafa

Ostatnie publikacje
1.  Arafa A.A., Nada A.A., Ibrahim A.Y., Sajkiewicz P., Zahran M.K., Hakeim O.A., Preparation and characterization of smart therapeutic pH-sensitive wound dressing from red cabbage extract and chitosan hydrogel, International Journal of Biological Macromolecules, ISSN: 0141-8130, DOI: 10.1016/j.ijbiomac.2021.05.167, Vol.182, pp.1820-1831, 2021

Developing a multifunctional wound dressing that protects, cures and indicates the healing progress, is a new approach of investigation. Red cabbage extract (RCE), consisting of bioactive compounds that have antioxidant, anti-inflammatory, anti-carcinogenic, bactericidal, antifungal, and antiviral activities, was utilized as a natural pH-sensitive indicator. Chitosan-based hydrogel, encapsulating RCE, was developed to obtain a smart therapeutic pH-sensitive wound dressing as antimicrobial bio-matrix provides a comfortable cushion for wound bed and indicates its status. Methacrylated-chitosan was crosslinked by different concentrations of methylenebisacrylamide (MBAA) by which hydrogel mechanical and morphological properties were tuned. The proposed mechanism for hydrogel formation was confirmed by FT-IR. The coloristic properties of the RCE and the changes in color intensity as a function of pH were confirmed by UV–Vis spectroscopy. The effect of MBAA on the mechanical, swelling, release and morphological properties of hydrogel were investigated. MBAA (2.5% wt/v) in 2% wt/v chitosan showed preferable mechanical (20 KPa), swelling (1294% at pH 8 ± 0.2), and release (prolonged up to 5 days) properties. Hydrogel matrices, loaded on cotton gauze submerged in different pH buffer solutions, showed explicit color changes from green to red as pH changed from 9 to 4.

Słowa kluczowe:
pH-sensitive dye, wound dressing, N-methacylated chitosan

Afiliacje autorów:
Arafa A.A. - inna afiliacja
Nada A.A. - inna afiliacja
Ibrahim A.Y. - inna afiliacja
Sajkiewicz P. - IPPT PAN
Zahran M.K. - inna afiliacja
Hakeim O.A. - inna afiliacja

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