Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk

Partnerzy

K. Fronczewska


Ostatnie publikacje
1.  Milej D., Gerega A., Żołek N., Weigl W., Kacprzak M., Sawosz P., Mączewska J., Fronczewska K., Mayzner-Zawadzka E., Królicki L., Maniewski R., Liebert A., Time-resolved detection of fluorescent light during inflow of ICG to the brain - a methodological study, PHYSICS IN MEDICINE AND BIOLOGY, ISSN: 0031-9155, DOI: 10.1088/0031-9155/57/20/6725, Vol.57, pp.6725-6742, 2012

Streszczenie:
It was reported that time-resolved reflectance measurements carried out during inflow and washout of an optical contrast agent may provide information on the blood supply to the brain cortex of human adults. It was also shown that a measurement of fluorescence excited in the dye circulating in the brain is feasible. Unfortunately, patterns of time-resolved fluorescence signals observed during in vivo measurements are difficult to interpret. The aim of this study was to analyze the influence of several factors on the fluorescence signals measured during in vivo experiments. A laboratory instrument for recording the distributions of arrival of fluorescence photons was constructed and optimized for measurements on humans. Monte Carlo simulations and laboratory measurements on liquid phantoms as well as in vivo measurements on healthy volunteers were carried out. An influence of source–detector separation, position of the source–detector pair on the head, as well as a dose of the injected indocyanine green (ICG) on the fluorescence signals were studied in detail. It was shown that even for a small dose of ICG (0.025 mg kg−1) the time-resolved signals can be successfully detected on the surface of the head. Strong influence of the studied factors on the fluorescence signals was observed. It was also noted that the changes in moments of distributions of arrival times of fluorescence photons depend on the anatomical structure of the tissues located between the source and the detector.

Afiliacje autorów:
Milej D. - Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL)
Gerega A. - inna afiliacja
Żołek N. - inna afiliacja
Weigl W. - inna afiliacja
Kacprzak M. - Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL)
Sawosz P. - Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL)
Mączewska J. - inna afiliacja
Fronczewska K. - inna afiliacja
Mayzner-Zawadzka E. - inna afiliacja
Królicki L. - inna afiliacja
Maniewski R. - inna afiliacja
Liebert A. - Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL)
35p.

Kategoria A Plus

IPPT PAN

logo ippt            ul. Pawińskiego 5B, 02-106 Warszawa
  +48 22 826 12 81 (centrala)
  +48 22 826 98 15
 

Znajdź nas

mapka
© Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk 2021