Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk

Partnerzy

L. De Sio

Sapienza University of Rome (IT)

Ostatnie publikacje
1.  De Sio L., Ding B., Focsan M., Kogermann K., Pascoal-Faria P., Petronella F., Mitchell G., Zussman E., Pierini F., Personalized reusable face masks with smart nano‐assisted destruction of pathogens for COVID‐19: a visionary road, Chemistry - A European Journal, ISSN: 0947-6539, DOI: 10.1002/chem.202004875, Vol.27, pp.1-20, 2021

Streszczenie:
The Coronavirus disease 2019 (COVID‐19) emergency has demonstrated that the utilization of face masks plays a critical role in limiting the outbreaks. Healthcare professionals utilize masks all day long without replacing them very frequently, thus representing a source of cross‐infection for patients and themselves. Nanotechnology is a powerful tool with the capability to produce nanomaterials with unique physicochemical and anti‐pathogen properties. Here, we outline how to realize non‐disposable and highly comfortable respirators with light‐triggered self‐disinfection ability by bridging bioactive nanofiber properties and stimuli‐responsive nanomaterials. The visionary road highlighted in this Concept is based on the possibility to develop a new generation of masks based on multifunctional membranes where the presence of nanoclusters and plasmonic nanoparticles arranged in a hierarchical structure enables the realization of a chemically‐driven and on‐demand anti‐pathogen activities. Multilayer electrospun membranes have the ability to dissipate humidity present within the mask, enhancing the wearability and usability. The photo‐thermal disinfected membrane is the core of these 3D printed and reusable masks with moisture pump capability. Personalized face masks with smart nano‐assisted destruction of pathogens will bring enormous advantages to the entire global community, especially for front‐line personnel, and will open up great opportunities for innovative medical applications.

Słowa kluczowe:
face masks, light-responsive nanomaterials, anti-pathogen, electrospinning, digitally personalized

Afiliacje autorów:
De Sio L. - Sapienza University of Rome (IT)
Ding B. - Donghua University (CN)
Focsan M. - inna afiliacja
Kogermann K. - inna afiliacja
Pascoal-Faria P. - inna afiliacja
Petronella F. - inna afiliacja
Mitchell G. - inna afiliacja
Zussman E. - Technion - Israel Institute of Technology (IL)
Pierini F. - IPPT PAN
140p.
2.  Rinoldi C., Zargarian S.S., Nakielski P., Li X., Liguori A., Petronella F., Presutti D., Wang Q., Costantini M., De Sio L., Gualandi C., Ding B., Pierini F., Nanotechnology-assisted RNA delivery: from nucleic acid therapeutics to COVID-19 vaccines, Small Methods, ISSN: 2366-9608, DOI: 10.1002/smtd.202100402, Vol.5, No.9, pp.2100402-1-49, 2021

Streszczenie:
In recent years, the main quest of science has been the pioneering of the groundbreaking biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids (RNAs) are outstanding bioactive macromolecules identified as pivotal actors in regulating a wide range of biochemical pathways. The ability to intimately control the cell fate and tissue activities makes RNA-based drugs the most fascinating family of bioactive agents. However, achieving a widespread application of RNA therapeutics in humans is still a challenging feat, due to both the instability of naked RNA and the presence of biological barriers aimed at hindering the entrance of RNA into cells. Recently, material scientists’ enormous efforts have led to the development of various classes of nanostructured carriers customized to overcome these limitations. This work systematically reviews the current advances in developing the next generation of drugs based on nanotechnology-assisted RNA delivery. The features of the most used RNA molecules are presented, together with the development strategies and properties of nanostructured vehicles. Also provided is an in-depth overview of various therapeutic applications of the presented systems, including coronavirus disease vaccines and the newest trends in the field. Lastly, emerging challenges and future perspectives for nanotechnology-mediated RNA therapies are discussed.

Afiliacje autorów:
Rinoldi C. - IPPT PAN
Zargarian S.S. - IPPT PAN
Nakielski P. - IPPT PAN
Li X. - Donghua University (CN)
Liguori A. - University of Bologna (IT)
Petronella F. - inna afiliacja
Presutti D. - Institute of Physical Chemistry, Polish Academy of Sciences (PL)
Wang Q. - Donghua University (CN)
Costantini M. - Sapienza University of Rome (IT)
De Sio L. - Sapienza University of Rome (IT)
Gualandi C. - University of Bologna (IT)
Ding B. - Donghua University (CN)
Pierini F. - IPPT PAN
100p.
3.  Guglielmelli A., Pierini F., Tabiryan N., Umeton C., Bunning T.J., De Sio L., Thermoplasmonics with gold nanoparticles: a new weapon in modern optics and biomedicine, Advanced Photonics Research, ISSN: 2699-9293, DOI: 10.1002/adpr.202000198, Vol.2, No.8, pp.2000198-1-17, 2021

Streszczenie:
Thermoplasmonics deals with the generation and manipulation of nanoscale heating associated with noble metallic nanoparticles. To this end, gold nanoparticles (AuNPs) are unique nanomaterials with the intrinsic capability to generate a nanoscale confined light-triggered thermal effect. This phenomenon is produced under the excitation of a suitable light of a wavelength that matches the localized surface plasmonic resonance frequency of AuNPs. Liquid crystals (LCs) and hydrogels are temperature-sensitive materials that can detect the host AuNPs and their photo-induced temperature variations. In this perspective, new insight into thermoplasmonics, by describing a series of methodologies for monitoring, detecting, and exploiting the photothermal properties of AuNPs, is offered. From conventional infrared thermography to highly sophisticated temperature-sensitive materials such as LCs and hydrogels, a new scenario in thermoplasmonic-based, next generation, photonic components is presented and discussed. Moreover, a new road in thermoplasmonic-driven biomedical applications, by describing compelling and innovative health technologies such as on-demand drug-release and smart face masks with smart nano-assisted destruction of pathogens, is proposed. The latter represents a new weapon in the fight against COVID-19.Thermoplasmonics deals with the generation and manipulation of nanoscale heating associated with noble metallic nanoparticles. To this end, gold nanoparticles (AuNPs) are unique nanomaterials with the intrinsic capability to generate a nanoscale confined light-triggered thermal effect. This phenomenon is produced under the excitation of a suitable light of a wavelength that matches the localized surface plasmonic resonance frequency of AuNPs. Liquid crystals (LCs) and hydrogels are temperature-sensitive materials that can detect the host AuNPs and their photo-induced temperature variations. In this perspective, new insight into thermoplasmonics, by describing a series of methodologies for monitoring, detecting, and exploiting the photothermal properties of AuNPs, is offered. From conventional infrared thermography to highly sophisticated temperature-sensitive materials such as LCs and hydrogels, a new scenario in thermoplasmonic-based, next generation, photonic components is presented and discussed. Moreover, a new road in thermoplasmonic-driven biomedical applications, by describing compelling and innovative health technologies such as on-demand drug-release and smart face masks with smart nano-assisted destruction of pathogens, is proposed. The latter represents a new weapon in the fight against COVID-19.

Afiliacje autorów:
Guglielmelli A. - University of Calabria (IT)
Pierini F. - IPPT PAN
Tabiryan N. - inna afiliacja
Umeton C. - University of Calabria (IT)
Bunning T.J. - inna afiliacja
De Sio L. - Sapienza University of Rome (IT)
4.  Nakielski P., Pawłowska S., Rinoldi C., Ziai Y., De Sio L., Urbanek O., Zembrzycki K., Pruchniewski M., Lanzi M., Salatelli E., Calogero A., Kowalewski T.A., Yarin A.L., Pierini F., Multifunctional platform based on electrospun nanofibers and plasmonic hydrogel: a smart nanostructured pillow for near-Infrared light-driven biomedical applications, ACS Applied Materials and Interfaces, ISSN: 1944-8244, DOI: 10.1021/acsami.0c13266, Vol.12, No.49, pp.54328-54342, 2020

Streszczenie:
Multifunctional nanomaterials with the ability torespond to near-infrared (NIR) light stimulation are vital for thedevelopment of highly efficient biomedical nanoplatforms with apolytherapeutic approach. Inspired by the mesoglea structure ofjellyfish bells, a biomimetic multifunctional nanostructured pillowwith fast photothermal responsiveness for NIR light-controlled on-demand drug delivery is developed. We fabricate a nanoplatformwith several hierarchical levels designed to generate a series ofcontrolled, rapid, and reversible cascade-like structural changesupon NIR light irradiation. The mechanical contraction of thenanostructured platform, resulting from the increase of temper-ature to 42°C due to plasmonic hydrogel−light interaction, causesa rapid expulsion of water from the inner structure, passing through an electrospun membrane anchored onto the hydrogel core. Themutual effects of the rise in temperature and waterflow stimulate the release of molecules from the nanofibers. To expand thepotential applications of the biomimetic platform, the photothermal responsiveness to reach the typical temperature level forperforming photothermal therapy (PTT) is designed. The on-demand drug model penetration into pig tissue demonstrates theefficiency of the nanostructured platform in the rapid and controlled release of molecules, while the high biocompatibility confirmsthe pillow potential for biomedical applications based on the NIR light-driven multitherapy strategy.

Słowa kluczowe:
bioinspired materials, NIR-light responsive nanomaterials, multifunctional platforms, electrospun nanofibers, plasmonic hydrogel, photothermal-based polytherapy, on-demand drug delivery

Afiliacje autorów:
Nakielski P. - IPPT PAN
Pawłowska S. - IPPT PAN
Rinoldi C. - IPPT PAN
Ziai Y. - IPPT PAN
De Sio L. - Sapienza University of Rome (IT)
Urbanek O. - IPPT PAN
Zembrzycki K. - IPPT PAN
Pruchniewski M. - inna afiliacja
Lanzi M. - University of Bologna (IT)
Salatelli E. - University of Bologna (IT)
Calogero A. - Sapienza University of Rome (IT)
Kowalewski T.A. - IPPT PAN
Yarin A.L. - Technion - Israel Institute of Technology (IL)
Pierini F. - IPPT PAN
200p.
5.  Pierini F., Guglielmelli A., Urbanek O., Nakielski P., Pezzi L., Buda R., Lanzi M., Kowalewski T.A., De Sio L., Thermoplasmonic‐activated hydrogel based dynamic light attenuator, Advanced Optical Materials, ISSN: 2195-1071, DOI: 10.1002/adom.202000324, Vol.8, No.12, pp.2000324-1-7, 2020

Streszczenie:
This work describes the morphological, optical, and thermo‐optical properties of a temperature‐sensitive hydrogel poly(N‐isopropylacrylamide‐co‐N‐isopropylmethacrylamide) [P(NIPAm‐co‐NIPMAm]) film containing a specific amount of gold nanorods (GNRs). The light‐induced thermoplasmonic heating of GNRs is used to control the optical scattering of an initially transparent hydrogel film. A hydrated P(NIPAm‐co‐NIPMAm) film is optically clear at room temperature. When heated to temperatures over 37 °C via light irradiation with a resonant source (λ = 810 nm) to the GNRs, a reversible phase transition from a swollen hydrated state to a shrunken dehydrated state occurs. This phenomenon causes a drastic and reversible change in the optical transparency from a clear to an opaque state. A significant red shift (≈30 nm) of the longitudinal band can also be seen due to an increased average refractive index surrounding the GNRs. This change is in agreement with an ad hoc theoretical model which uses a modified Gans theory for ellipsoidal nanoparticles. Morphological analysis of the composite film shows the presence of well‐isolated and randomly dispersed GNRs. Thermo‐optical experiments demonstrate an all‐optically controlled light attenuator (65% contrast ratio) which can be easily integrated in several modern optical applications such as smart windows and light‐responsive optical attenuators.

Słowa kluczowe:
active plasmonics, gold nanorods, hydrogels, optical attenuators, optical transparency, plasmonic nanoparticles, polymers

Afiliacje autorów:
Pierini F. - IPPT PAN
Guglielmelli A. - University of Calabria (IT)
Urbanek O. - IPPT PAN
Nakielski P. - IPPT PAN
Pezzi L. - inna afiliacja
Buda R. - Institute of Physical Chemistry, Polish Academy of Sciences (PL)
Lanzi M. - University of Bologna (IT)
Kowalewski T.A. - IPPT PAN
De Sio L. - Sapienza University of Rome (IT)
140p.
6.  Pierini F., Nakielski P., Urbanek O., Pawłowska S., Lanzi M., De Sio L., Kowalewski T.A., Polymer-Based Nanomaterials for Photothermal Therapy: From Light-Responsive to Multifunctional Nanoplatforms for Synergistically Combined Technologies, BIOMACROMOLECULES, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01138, Vol.19, No.11, pp.4147-4167, 2018

Streszczenie:
Materials for the treatment of cancer have been studied comprehensively over the past few decades. Among the various kinds of biomaterials, polymer-based nanomaterials represent one of the most interesting research directions in nanomedicine because their controlled synthesis and tailored designs make it possible to obtain nanostructures with biomimetic features and outstanding biocompatibility. Understanding the chemical and physical mechanisms behind the cascading stimuli-responsiveness of smart polymers is fundamental for the design of multifunctional nanomaterials to be used as photothermal agents for targeted polytherapy. In this review, we offer an in-depth overview of the recent advances in polymer nanomaterials for photothermal therapy, describing the features of three different types of polymer-based nanomaterials. In each case, we systematically show the relevant benefits, highlighting the strategies for developing light-controlled multifunctional nanoplatforms that are responsive in a cascade manner and addressing the open issues by means of an inclusive state-of-the-art review. Moreover, we face further challenges and provide new perspectives for future strategies for developing novel polymeric nanomaterials for photothermally assisted therapies.

Afiliacje autorów:
Pierini F. - IPPT PAN
Nakielski P. - IPPT PAN
Urbanek O. - IPPT PAN
Pawłowska S. - IPPT PAN
Lanzi M. - University of Bologna (IT)
De Sio L. - Sapienza University of Rome (IT)
Kowalewski T.A. - IPPT PAN
45p.

Abstrakty konferencyjne
1.  Pierini F., Nakielski P., Pawłowska S., Rinoldi C., Ziai Y., Urbanek-Świderska O., De Sio L., Calogero A., Lanzi M., Zembrzycki K., Pruchniewski M., Salatelli E., Kowalewski T.A., Yarin A., Nature-inspired smart drug delivery platforms based on electrospun nanofibers and plasmonic hydrogels for near-infrared light-controlled polytherapy, Polymer Connect, Polymer Science and Composite Materials Conference, 2020-02-26/02-28, LISBON (PT), pp.7, 2020
2.  Nakielski P., De Sio L., Buda R., Guglielmelli A., Pawłowska S., Urbanek O., Kowalewski T.A., Pierini F., Photo-responsive PNIPAM-Gold Nanorods Hydrogel For Biomedical Applications, NOMA2019, The 14th Mediterranean Workshop and Topical Meeting, 2019-06-02/06-08, Cetraro (IT), pp.80-80, 2019

Streszczenie:
Stimuli-responsive drug delivery systems are gaining a lot of interest due to their numerous advantages, especially when compared to conventional pharmaceutical dosage forms. One of the examples is photo stimulation that together with nanometer size agents, having high absorption in the near-infrared region, generate heat due to the interaction with light. Stimuli-responsive hydrogels with gold nanorods (AuNRs), that are used as photothermal converters, can aid in releasing drugs on-demand with a fast release rate through different mechanisms. Here we report an easy method for preparing AuNRs encapsulated in a poly(N-isopropylacrylamide) (PNIPAm) hydrogel that release water-soluble drugs due to photo stimulation. PNIPAm-AuNRs demonstrated remote, pulsatile drug release and ex vivo action after irradiation using a NIR laser. Morphological and chemical characterization as well as drug release studies were carried out to confirm the material’s ability to supply different doses of drugs on demand and to study the release mechanism. By combining the photothermal property of AuNRs and thermal-responsive effect of PNIPAm, the hydrogel shows fast thermal/photoresponse, high heating rate, high structural integrity and increased drug release due to phase change mechanism.

Słowa kluczowe:
drug delivery systems, nanofibers

Afiliacje autorów:
Nakielski P. - IPPT PAN
De Sio L. - Sapienza University of Rome (IT)
Buda R. - Institute of Physical Chemistry, Polish Academy of Sciences (PL)
Guglielmelli A. - University of Calabria (IT)
Pawłowska S. - IPPT PAN
Urbanek O. - IPPT PAN
Kowalewski T.A. - IPPT PAN
Pierini F. - IPPT PAN

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