Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk


Marzena Ciechomska

National Institute of Geriatrics, Rheumatology and Rehabilitation (PL)

Ostatnie publikacje
1.  Kołbuk D., Ciechomska M., Jeznach O., Sajkiewicz P., Effect of crystallinity and related surface properties on gene expression of primary fibroblasts, RSC Advances, ISSN: 2046-2069, DOI: 10.1039/D1RA07237D, Vol.12, No.7, pp.4016-4028, 2022

The biomaterial-cells interface is one of the most fundamental issues in tissue regeneration. Despite many years of scientific work, there is no clear answer to what determines the desired adhesion of cells and the synthesis of ECM proteins. Crystallinity is a characteristic of the structure that influences the surface and bulk properties of semicrystalline polymers used in medicine. The crystallinity of polycaprolactone (PCL) was varied by changing the molecular weight of the polymer and the annealing procedure. Measurements of surface free energy showed differences related to substrate crystallinity. Additionally, the water contact angle was determined to characterise surface wettability which was crucial in the analysis of protein absorption. X-ray photoelectron spectroscopy was used to indicate oxygen bonds amount on the surface. Finally, the impact of the crystallinity, and related properties were demonstrated on dermal fibroblasts' response. Cellular proliferation and expression of selected genes: α-SMA, collagen I, TIMP, integrin were analysed.

Afiliacje autorów:
Kołbuk D. - IPPT PAN
Ciechomska M. - National Institute of Geriatrics, Rheumatology and Rehabilitation (PL)
Jeznach O. - IPPT PAN
Sajkiewicz P. - IPPT PAN

Kategoria A Plus


logo ippt            ul. Pawińskiego 5B, 02-106 Warszawa
  +48 22 826 12 81 (centrala)
  +48 22 826 98 15

Znajdź nas

© Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk 2024