Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk


mgr Piotr Topolewski

Zakład Biosystemów i Miękkiej Materii (ZBiMM)
stanowisko: kierownik projektu
telefon: (+48) 22 826 12 81 wewn.: 468
pokój: 309
ORCID: 0000-0003-4502-042X

Ostatnie publikacje
1.  Topolewski P., Komorowski M., Information-theoretic analyses of cellular strategies for achieving high signaling capacity—dynamics, cross-wiring, and heterogeneity of cellular states, Current Opinion in Systems Biology, ISSN: 2452-3100, DOI: 10.1016/j.coisb.2021.06.003, Vol.27, pp.100352-1-9, 2021

An individual eukaryotic cell senses identity and quantity of ligands through molecular receptors and signaling pathways, dynamically activating signaling effectors. A distinct ligand often activates multiple different effectors, and a distinct effector is activated by numerous different ligands, which results in cross-wired signaling. In apparently identical cells, the activity of signaling effectors can vary considerably, raising questions about the accuracy of cellular signaling and the interpretation of heterogeneous responses, as either functional or simply noise. Cell-to-cell variability of signaling outcomes, signaling dynamics, and cross-wiring all give rise to signaling complexity, complicating the analysis of signaling mechanisms. Here, we consider a simple input–output modeling approach of information theory that is suitable to analyze signaling complexity and highlight recent studies that have advanced our understanding of the role different components of signaling complexity play in achieving effective information transfer along cellular signaling pathways.

Słowa kluczowe:
signaling pathways, hormones, growth factors or cytokines, signaling dynamics, cross-wired signaling, Shannon information, Fisher information

Afiliacje autorów:
Topolewski P. - IPPT PAN
Komorowski M. - IPPT PAN

Abstrakty konferencyjne
1.  Zakrzewska K.E., Jetka T., Nienałtowski K., Szymańska K., Andryka K., Topolewski P., Głów E., Komorowski M., Sensing and remembering IFNs concentrations, Cytokine, ISSN: 1043-4666, DOI: 10.1016/j.cyto.2017.09.011, Vol.100, pp.Mo-P7-12-100-100, 201725p.
2.  Topolewski P., Komorowski M., Cell cycle does not contribute to cell-to-cell heterogeneity of interferon responses, Cytokine, ISSN: 1043-4666, DOI: 10.1016/j.cyto.2017.09.011, Vol.100, pp.Mo-P7-11-100-100, 201725p.

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