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Streszczenie:
Rice husk ash (RHA), an abundant agricultural and industrial waste, was upcycled into functional mesostructured silica encapsulating cetylpyridinium chloride (CPC), an FDA-approved antiseptic. Sodium
silicate was efficiently extracted from RHA and leveraged as a biosourced silica precursor for the aqueous sol–gel synthesis of mesostructured hybrid silica at 30 1C. Micelles of CPC simultaneously acted as structure-directing agents and as integrated antimicrobial cargo, enabling the direct formation of ordered hybrids in
one-pot. The condensation pH influenced the synthesis yield, the bonding configuration of silicon, the encapsulation of CPC and the nanostructure of the hybrids. An optimal condensation pH of 11 with a 10 : 1
Si : CPC ratio enabled highly ordered mesostructured hybrids comprising around 40 wt% of CPC and a large proportion of silanolate sites promoting electrostatic interactions. Calcination of these materials unveiled mesoporous silica with well-ordered 2D hexagonal mesophases of cylindrical pores (B2.3 nm in diameter) and high surface areas up to 520 m2 g-1. Increasing the CPC content of the hybrid materials was possible by adjusting the Si : CPC ratio. The mesostructured hybrids exhibited limited CPC release (4–5%) under physiological pH conditions, highlighting their potential for slow and burst-free release. Consequently, they exhibited potent broad-spectrum antimicrobial efficacy with a CPC dose-dependent effect (evaluated by inhibition
zones, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC)) against a representative panel of pathogens: aerobic (Staphylococcus aureus, Enterococcus faecalis) and anaerobic
(Streptococcus mutans, Porphyromonas gingivalis) bacteria, as well as the fungal pathogen Candida albicans.
Notably, the mesostructured hybrids exerted antiseptic effects not only through direct contact with microorganisms but also via CPC diffusion. These results established RHA-derived CPC-loaded mesoporous
silica as a sustainable, high-value platform for next-generation antimicrobial applications, contributing to circular economy efforts, healthcare, and environmental sectors.

Słowa kluczowe:
upcycling rice husk , antiseptic, mesoporous silica materials, antimicrobial

Streszczenie:
New Surfactant PolyIon Complex (SPIC) micelles were assembled by electrostatic complexation of an antibacterial cationic surfactant, cetylpyridinium chloride (CPC), and a double hydrophilic block copolymer (DHBC) containing a neutral comb block of poly(oligo(ethylene glycol)) methyl ether acrylate (PEOGA) and a weak polyacid block of poly(acrylic acid) (PAA). The corresponding SPIC micelles, with a CPC/PAA core and a PEOGA corona, were successfully used as structure directing and functionalizing agents in a soft and sustainable sol-gel strategy, yielding hybrid mesoporous silica (MS) materials with a monomodal pore size distribution centred at 2.8 nm. The influence of synthesis parameters, including the pH, concentrations and ratios of components, was systematically investigated. The obtained hybrid MS materials were intrinsically functional, with PEOGA blocks anchored in silica walls via H-bonding, while weak polyacid blocks, complexed with CPC, were confined within the mesopores. The response of the materials to pH changes (pH 7.4, 4.2 and 3) indicated remarkable stability of the anchored DHBC, while CPC was selectively released under the acidic conditions typical of orodental biofilm microenvironments. This result is noteworthy, since the release of encapsulated amphiphilic drugs into water is less favorable than that of hydrophilic drugs. Owing to the control of their pore and functionality properties, ordered hybrid silica materials templated and functionalized with SPIC systems will be materials of choice for developing pH-responsive biomedical devices using wet processing techniques

Słowa kluczowe:
Double hydrophilic block copolymer, Cooperative self-assembly, Surfactant-polyion complex micelle, Stimuli-responsive nanomaterials, Sustainable, Sol-gel synthesis

Słowa kluczowe:
poly-ion complex micelles, functional mesoporous materials, thin films

Słowa kluczowe:
mesostructured silica materials , rice husk ash upcycling , antiseptic, electrochemical properties