Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk

Partnerzy

Antonella Calogero

Sapienza University of Rome (IT)

Ostatnie publikacje
1.  Nakielski P., Pawłowska S., Rinoldi C., Ziai Y., De Sio L., Urbanek O., Zembrzycki K., Pruchniewski M., Lanzi M., Salatelli E., Calogero A., Kowalewski T.A., Yarin A.L., Pierini F., Multifunctional platform based on electrospun nanofibers and plasmonic hydrogel: a smart nanostructured pillow for near-Infrared light-driven biomedical applications, ACS Applied Materials and Interfaces, ISSN: 1944-8244, DOI: 10.1021/acsami.0c13266, Vol.12, No.49, pp.54328-54342, 2020

Streszczenie:
Multifunctional nanomaterials with the ability torespond to near-infrared (NIR) light stimulation are vital for thedevelopment of highly efficient biomedical nanoplatforms with apolytherapeutic approach. Inspired by the mesoglea structure ofjellyfish bells, a biomimetic multifunctional nanostructured pillowwith fast photothermal responsiveness for NIR light-controlled on-demand drug delivery is developed. We fabricate a nanoplatformwith several hierarchical levels designed to generate a series ofcontrolled, rapid, and reversible cascade-like structural changesupon NIR light irradiation. The mechanical contraction of thenanostructured platform, resulting from the increase of temper-ature to 42°C due to plasmonic hydrogel−light interaction, causesa rapid expulsion of water from the inner structure, passing through an electrospun membrane anchored onto the hydrogel core. Themutual effects of the rise in temperature and waterflow stimulate the release of molecules from the nanofibers. To expand thepotential applications of the biomimetic platform, the photothermal responsiveness to reach the typical temperature level forperforming photothermal therapy (PTT) is designed. The on-demand drug model penetration into pig tissue demonstrates theefficiency of the nanostructured platform in the rapid and controlled release of molecules, while the high biocompatibility confirmsthe pillow potential for biomedical applications based on the NIR light-driven multitherapy strategy.

Słowa kluczowe:
bioinspired materials, NIR-light responsive nanomaterials, multifunctional platforms, electrospun nanofibers, plasmonic hydrogel, photothermal-based polytherapy, on-demand drug delivery

Afiliacje autorów:
Nakielski P. - IPPT PAN
Pawłowska S. - IPPT PAN
Rinoldi C. - IPPT PAN
Ziai Y. - IPPT PAN
De Sio L. - Sapienza University of Rome (IT)
Urbanek O. - IPPT PAN
Zembrzycki K. - IPPT PAN
Pruchniewski M. - inna afiliacja
Lanzi M. - University of Bologna (IT)
Salatelli E. - University of Bologna (IT)
Calogero A. - Sapienza University of Rome (IT)
Kowalewski T.A. - IPPT PAN
Yarin A.L. - Technion - Israel Institute of Technology (IL)
Pierini F. - IPPT PAN
200p.

Abstrakty konferencyjne
1.  Pierini F., Nakielski P., Pawłowska S., Rinoldi C., Ziai Y., Urbanek-Świderska O., De Sio L., Calogero A., Lanzi M., Zembrzycki K., Pruchniewski M., Salatelli E., Kowalewski T.A., Yarin A., Nature-inspired smart drug delivery platforms based on electrospun nanofibers and plasmonic hydrogels for near-infrared light-controlled polytherapy, Polymer Connect, Polymer Science and Composite Materials Conference, 2020-02-26/02-28, LISBON (PT), pp.7, 2020

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