Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk


K. Kogermann

Ostatnie publikacje
1.  Cegielska O., Sierakowski M., Sajkiewicz P., Lorenz K., Kogermann K., Mucoadhesive brinzolamide-loaded nanofibers for alternative glaucoma treatment, European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2022.09.008, Vol.180, pp.48-62, 2022

Despite the advances in the field of pharmaceutical materials and technology, topical administration remains a method of choice for the treatment of eye diseases such as glaucoma, with eye drops being a leading dosage form. Their main disadvantage is a very short drug residence time and thus poor drug bioavailability, leading to the necessity of continuous repeated dosing. Mucoadhesive electrospun nanofibers are promising candidates for overcoming these challenges, while still benefiting from topical ocular administration. As an alternative for eye drops, a nanofibrous drug delivery system (DDS) for the delivery of brinzolamide (BRZ), based on β-cyclodextrin (β-CD), hydroxypropyl cellulose (HPC) and polycaprolactone (PCL), was designed. The results showed β-CD/BRZ guest–host interactions, successful drug incorporation into the nanofibers, and the possibility of more accurate dosing in comparison with the control eye drops. Drug permeation through sheep corneas was almost linear in time, achieving therapeutic concentrations in the receptor medium, and mucoadhesion to sheep eye mucosa was relatively high in case of formulations with high HPC content. All formulations were biocompatible, their mechanical properties were sufficient to handle them without caution and UV irradiation was suitable to reduce bioburden of the fibers matrix, yet no antibacterial properties of BRZ were observed.

Słowa kluczowe:
Drug delivery system, Nanofibers, Electrospinning, Cyclodextrins, Glaucoma, Mucoadhesion, Topical administration

Afiliacje autorów:
Cegielska O. - IPPT PAN
Sierakowski M. - inna afiliacja
Sajkiewicz P. - IPPT PAN
Lorenz K. - inna afiliacja
Kogermann K. - inna afiliacja
2.  De Sio L., Ding B., Focsan M., Kogermann K., Pascoal-Faria P., Petronella F., Mitchell G., Zussman E., Pierini F., Personalized reusable face masks with smart nano‐assisted destruction of pathogens for COVID‐19: a visionary road, Chemistry - A European Journal, ISSN: 0947-6539, DOI: 10.1002/chem.202004875, Vol.27, pp.1-20, 2021

The Coronavirus disease 2019 (COVID‐19) emergency has demonstrated that the utilization of face masks plays a critical role in limiting the outbreaks. Healthcare professionals utilize masks all day long without replacing them very frequently, thus representing a source of cross‐infection for patients and themselves. Nanotechnology is a powerful tool with the capability to produce nanomaterials with unique physicochemical and anti‐pathogen properties. Here, we outline how to realize non‐disposable and highly comfortable respirators with light‐triggered self‐disinfection ability by bridging bioactive nanofiber properties and stimuli‐responsive nanomaterials. The visionary road highlighted in this Concept is based on the possibility to develop a new generation of masks based on multifunctional membranes where the presence of nanoclusters and plasmonic nanoparticles arranged in a hierarchical structure enables the realization of a chemically‐driven and on‐demand anti‐pathogen activities. Multilayer electrospun membranes have the ability to dissipate humidity present within the mask, enhancing the wearability and usability. The photo‐thermal disinfected membrane is the core of these 3D printed and reusable masks with moisture pump capability. Personalized face masks with smart nano‐assisted destruction of pathogens will bring enormous advantages to the entire global community, especially for front‐line personnel, and will open up great opportunities for innovative medical applications.

Słowa kluczowe:
face masks, light-responsive nanomaterials, anti-pathogen, electrospinning, digitally personalized

Afiliacje autorów:
De Sio L. - Sapienza University of Rome (IT)
Ding B. - Donghua University (CN)
Focsan M. - inna afiliacja
Kogermann K. - inna afiliacja
Pascoal-Faria P. - inna afiliacja
Petronella F. - inna afiliacja
Mitchell G. - inna afiliacja
Zussman E. - Technion - Israel Institute of Technology (IL)
Pierini F. - IPPT PAN

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