Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk


S. Yu

Ostatnie publikacje
1.  Hou J., Li C., Jankowski Ł., Shi Y., Su L., Yu S., Geng T., Damage identification of suspender cables by adding virtual supports with the substructure isolation method, STRUCTURAL CONTROL AND HEALTH MONITORING, ISSN: 1545-2255, DOI: 10.1002/stc.2677, Vol.28, No.3, pp.e2677-1-19, 2021

Damage of bridge cables is mainly manifested as the decrease in cable forces. These forces are affected by the boundary conditions, cable length, cable stiffness, and cable appendages, making it hard to identify the cable forces. Based on the substructure isolation method, this study proposes an approach for cable force identification to judge cable damage by adding virtual supports to each cable so that the cables share the same length and boundary conditions. The cable forces can then be identified according to the relationship between the natural frequency and cable forces. The basic concept is that the boundary sensors are transformed into virtual supports by a linear combination of the convolution of measured responses to achieve the zero boundary response. A finite element model of a suspension bridge was used to validate the proposed method in a simulation. When the virtual supports were added to the cables, the relationship between the cable forces and the natural frequency was almost linear, and the cable damage could be successfully identified with 5% noise. Finally, the effectiveness of the proposed method was verified experimentally, and the natural frequency of the isolated cable substructure was confirmed to be a highly sensitive damage indicator.

Słowa kluczowe:
cable damage, cable forces, natural frequency, structural health monitoring (SHM), substructure isolation method, virtual supports

Afiliacje autorów:
Hou J. - Dalian University of Technology (CN)
Li C. - inna afiliacja
Jankowski Ł. - IPPT PAN
Shi Y. - inna afiliacja
Su L. - Dalian University of Technology (CN)
Yu S. - inna afiliacja
Geng T. - inna afiliacja
2.  Daniels Michael J.D., Rivers-Auty J., Schilling T., Spencer Nicholas G., Watremez W., Fasolino V., Booth Sophie J., White Claire S., Baldwin Alex G., Freeman S., Wong R., Latta C., Yu S., Jackson J., Fischer N., Koziel V., Pillot T., Bagnall J., Allan Stuart M., Paszek P., Galea J., Harte Michael K., Eder C., Lawrence Catherine B., Brough D., Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models, Nature Communications, ISSN: 2041-1723, DOI: 10.1038/ncomms12504, Vol.7, pp.12504-1-10, 2016

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the processing of the proinflammatory cytokine interleukin-1β and is implicated in many inflammatory diseases. Here we show that several clinically approved and widely used NSAIDs of the fenamate class are effective and selective inhibitors of the NLRP3 inflammasome via inhibition of the volume-regulated anion channel in macrophages, independently of COX enzymes. Flufenamic acid and mefenamic acid are efficacious in NLRP3-dependent rodent models of inflammation in air pouch and peritoneum. We also show therapeutic effects of fenamates using a model of amyloid beta induced memory loss and a transgenic mouse model of Alzheimer’s disease. These data suggest that fenamate NSAIDs could be repurposed as NLRP3 inflammasome inhibitors and Alzheimer’s disease therapeutics.

Afiliacje autorów:
Daniels Michael J.D. - inna afiliacja
Rivers-Auty J. - inna afiliacja
Schilling T. - inna afiliacja
Spencer Nicholas G. - inna afiliacja
Watremez W. - inna afiliacja
Fasolino V. - inna afiliacja
Booth Sophie J. - inna afiliacja
White Claire S. - inna afiliacja
Baldwin Alex G. - inna afiliacja
Freeman S. - inna afiliacja
Wong R. - inna afiliacja
Latta C. - inna afiliacja
Yu S. - inna afiliacja
Jackson J. - inna afiliacja
Fischer N. - inna afiliacja
Koziel V. - inna afiliacja
Pillot T. - inna afiliacja
Bagnall J. - inna afiliacja
Allan Stuart M. - inna afiliacja
Paszek P. - inna afiliacja
Galea J. - inna afiliacja
Harte Michael K. - inna afiliacja
Eder C. - inna afiliacja
Lawrence Catherine B. - inna afiliacja
Brough D. - inna afiliacja

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