Instytut Podstawowych Problemów Techniki
Polskiej Akademii Nauk


M. Szymaniak

Ostatnie publikacje
1.  Budnicka M., Szymaniak M., Kołbuk D., Ruśkowski P., Gadomska-Gajadhur A., Biomineralization of poly-l-lactide spongy bone scaffolds obtained by freeze-extraction method, Journal of Biomedical Materials Research Part B: Applied Biomaterials, ISSN: 1552-4973, DOI: 10.1002/jbm.b.34441, Vol.108, No.3, pp.868-879, 2020

Implants in the form of polymer scaffolds are commonly used to regenerate bone tissue after traumas or tooth extractions. However, few implant formation methods enable building polymer scaffolds allowing to reconstruct larger bone losses without immune response. Spacious, porous poly-l-lactide implants with considerable volume were obtained using the phase inversion method with the freeze-extraction variant. The calcium phosphate (CaP) coating was deposited on implant surfaces with the biomimetic method to improve the implant's osteoconductivity. The substitues morphology was characterized-porosity, size and shape of pores; mechanical properties, mass absorbability of implants before and after mineralization. The characteristics were provided with scanning electron microscopy (SEM), static compression test and hydrostatic weighing, respectively. The presence of CaPs in the entire volume of the implant was confirmed with SEM and infrared spectroscopy with Fourier transform (FTIR). The biocompatibility of scaffolds was confirmed with in vitro quantitative test and microscopic observations. The obtained results show that the implants can be used in tissue engineering as a vehicle of platelet-rich plasma to regenerate critical spongy bone losses.

Słowa kluczowe:
bone graft, calcium phosphate(s), cell culture

Afiliacje autorów:
Budnicka M. - inna afiliacja
Szymaniak M. - inna afiliacja
Kołbuk D. - IPPT PAN
Ruśkowski P. - Politechnika Warszawska (PL)
Gadomska-Gajadhur A. - Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL)

Numer/data zgłoszenia patentowego
Ogłoszenie o zgłoszeniu patentowym
Kraj i Nazwa uprawnionego z patentu
Numer patentu
Ogłoszenie o udzieleniu patentu
BUP 06/2020
Gadomska-Gajadhur A., Ruśkowski P., Synoradzki L., Wrzecionek M., Kołbuk-Konieczny D., Jeznach O., Budnicka M., Szymaniak M.
Sposób otrzymywania poli(bursztynianiu glicerolu)
PL, Politechnika Warszawska
WUP 18/2021

Kategoria A Plus


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